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Aceclidine

CAS No.
827-61-2
Chemical Name:
Aceclidine
Synonyms
NSC657843;Aceclidine;NSC 657843;NSC-657843;3-Acetoxyquinuclidine;3-Quinuclidinyl acetate;quinuclidin-3-yl acetate;Quinuclidine-3-ol acetate;3-Quinuclidinol acetate ester;Acetic acid quinuclidin-3-yl ester
CBNumber:
CB6512307
Molecular Formula:
C9H15NO2
Molecular Weight:
169.22
MDL Number:
MFCD00468105
MOL File:
827-61-2.mol
MSDS File:
SDS
Last updated:2023-09-04 15:51:00

Aceclidine Properties

Boiling point 298.52°C (rough estimate)
Density 1.0873 (rough estimate)
refractive index 1.4780 (estimate)
storage temp. Sealed in dry,Store in freezer, under -20°C
pka 9.22±0.33(Predicted)
FDA UNII 0578K3ELIO
ATC code S01EB08,S01EB58

SAFETY

Risk and Safety Statements

Toxicity LD50 scu-rat: 225 mg/kg ARZNAD 18,320,68

Aceclidine price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-B0278 quinuclidin-3-ylacetate >98.0% 827-61-2 250mg $75 2021-12-16 Buy
ChemScene CS-B0278 quinuclidin-3-ylacetate >98.0% 827-61-2 1g $144 2021-12-16 Buy
ChemScene CS-B0278 quinuclidin-3-ylacetate >98.0% 827-61-2 5g $454 2021-12-16 Buy
ChemScene CS-B0278 quinuclidin-3-ylacetate >98.0% 827-61-2 10g $832 2021-12-16 Buy
Medical Isotopes, Inc. 18442 Aceclidine 827-61-2 5mg $950 2021-12-16 Buy
Product number Packaging Price Buy
CS-B0278 250mg $75 Buy
CS-B0278 1g $144 Buy
CS-B0278 5g $454 Buy
CS-B0278 10g $832 Buy
18442 5mg $950 Buy

Aceclidine Chemical Properties,Uses,Production

Originator

Glacostat ,MSD-Chibret ,France ,1966

Uses

analgesic (topical), depletes Substance P, neurotoxic

Definition

ChEBI: Acetic acid 1-azabicyclo[2.2.2]octan-3-yl ester is a member of quinuclidines.

Manufacturing Process

A mixture of 274 g of methyl isonicotinate, 367 g of ethyl bromoacetate and 125 cc of ethyl alcohol was stirred without heating for 4 hours in a flask equipped with a reflux condenser. (The reaction was exothermic and precautions were taken to keep the temperature below 70°C.) The reaction mixture was then left for 15 hours at room temperature.
The reaction product (1-carbethoxymethyl-4-carbornethoxy-pyridinium bromide) was obtained in crystalline form. (It formed prisms melting at 166- 169°C after recrystallization from a mixture of isopropanol and acetone.) It was not necessary to isolate it. For the following reduction step, the reaction mixture was brought into solution by the addition of about 1 liter of warm ethyl alcohol. It was then hydrogenated at about 30 atm pressure in the presence of 2 g of platinum oxide. The temperature rose during this reaction to about 40°C. After the calculated amount of hydrogen had been absorbed, the catalyst was filtered off, the solution was concentrated in vacuum, and the residual syrup was dissolved in ice water. Benzene was added and the mixture was made alkaline with an excess of concentrated ice cold potassium carbonate solution. The temperature was kept low by continuous addition of ice, and the benzene layer was separated and dried with sodium sulfate. The dried benzene solution was concentrated in vacuum and the residual oil was distilled in vacuum. BP 30 mm = 175-182°C, nD 25= 1.4613-1.4628. During the reduction, partial alcoholysis occurred, and the product isolated was 1- carbethoxymethyl-4-"carbalkoxy"-piperidine, wherein "carbalkoxy" represents a mixture of carbomethoxy and carbethoxy.
100 g of potassium were pulverized in 200 cc of hot toluene in a heated three-neck flask equipped with an efficient condenser, stirrer and dropping funnel. To the refluxing potassium suspension were added in small portions 229 g of the product of the previous step and about 700 cc of toluene. This addition had to be carried out very cautiously; the onset of the exothermic reaction is sometimes delayed. The addition was finished in about 1 hour. To complete the reaction, the refluxing and stirring were continued for about 4 hours. The reaction mixture was then cooled to about +5°C and about 50 cc isopropanol were added to decompose unreacted potassium. Then 2.5 liters of concentrated hydrochloric acid were added and the mixture was refluxed for 15 hours, and then concentrated in vacuum to dryness. To the residue was added with cooling an excess of 50% potassium hydroxide. Ether was then added and the resulting mixture was filtered through a fritted glass funnel, thus removing the precipitated potassium chloride. The ethereal and aqueous layers were separated, and the aqueous layer was extracted repeatedly with 500 cc portions of ether. The organic solutions were combined, dried over sodium sulfate and concentrated in vacuum. Aqueous hydrochloric acid was added to the residue until the solution became acid. The mixture was then diluted with distilled water to about 300 cc, heated with decolorizing charcoal, filtered and concentrated in vacuum to dryness. The residue was treated with isopropanol, and the precipitated crystalline product was filtered off. The product was recrystallized from a mixture of water and isopropanol and was identified as 1-azabicyclo[2.2.2]-3-octanone hydrochloride; prisms, MP 311- 313°C, with decomposition.
A solution of 50 g of the above ketone-hydrochloride in 30 cc of water was made alkaline by the addition of 30 g of potassium hydroxide. After the alkali was dissolved, 35 g of granular potassium carbonate were added. The free basic ketone was then extracted from the viscous mixture by shaking with 4 portions of hot benzene (300 cc in each portion). The benzene extracts were decanted, filtered over sodium sulfate in order to remove any suspended alkali, and concentrated in vacuum. The residual lszabicyclo[2.2.2]-3-octanone was purified by sublimation (50-70°C/0.5 mm Hg); it can also be purified by recrystallization from petroleum ether. It formed feathery crystals melting at 147-148°C.
The product was reduced as follows: A solution of 50 g of 1-azabicyclo[2.2.2]-3-octanone hydrochloride in 200 cc of water was hydrogenated at room temperature and 50 atm pressure with 1 g of platinum oxide as catalyst. After the calculated amount of hydrogen had been absorbed, the mixture was filtered and concentrated in vacuum to dryness. The residual product was recrystallized from a mixture of methanol and acetone and formed prisms melting above 300°C. It was identified as 1- azabicyclo[2.2.2]-3-octanol hydrochloride.
A solution of 50 g of 1-azabicyclo[2.2.2]-3-octanol hydrochloride in 30 cc water was made alkaline with 30 g of potassium hydroxide. After the alkali was dissolved 35 g of granular potassium carbonate were added. The free basic alcohol was then extracted from the viscous mixture by shaking with four portions of boiling benzene (300 cc in each portion). The benzene extracts were decanted and filtered over anhydrous sodium sulfate, to remove any suspended alkali. The combined benzene solutions were concentrated in vacuum. The residue was recrystallized from benzene and identified as lszabicyclo[2.2.2]-3-octanol, MP 221-223°C. The product can also be purified by recrystallization from acetone, or by sublimation in vacuum (120°C/20 mm Hg). The alcohol was reacted with acetic anhydride to give the product aceclidine.

brand name

Cholinergic Glaucostat (Kingshill Pharmaceuticals, Inc, Switzerland).

Therapeutic Function

Miotic, Cholinomimetic

Safety Profile

Poison by ingestion, subcutaneous,and intravenous routes. When heated to decomposition itemits toxic fumes of NOx.

Aceclidine Preparation Products And Raw materials

Global( 67)Suppliers
Supplier Tel Email Country ProdList Advantage
Hangzhou FandaChem Co.,Ltd.
008657128800458; +8615858145714 fandachem@gmail.com China 9354 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29914 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 47465 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
CR Corporation Lomited
fred.wen@crcorporation.cn CHINA 12069 58
Hebei Guanlang Biotechnology Co., Ltd.
+86-19930503259 +86-19930503259 cherry@crovellbio.com China 18459 58
Zibo Hangyu Biotechnology Development Co., Ltd
+86-0533-2185556 +8617865335152 Mandy@hangyubiotech.com China 11001 58
LEAPCHEM CO., LTD.
+86-852-30606658 market18@leapchem.com China 43348 58

View Lastest Price from Aceclidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Aceclidine pictures 2019-07-06 Aceclidine
827-61-2
US $1.00 / kg 1kg 98% 200KG Career Henan Chemical Co
  • Aceclidine pictures
  • Aceclidine
    827-61-2
  • US $1.00 / kg
  • 98%
  • Career Henan Chemical Co

Aceclidine Spectrum

1-AZABICYCLO[2.2.2]OCTAN-3-OL, ACETATE (ESTER) 3-Acetoxyquinuclidine Acetic acid 1-azabicyclo[2.2.2]octane-3-yl ester Acetic acid quinuclidin-3-yl ester Quinuclidine-3-ol acetate quinuclidin-3-yl acetate 1-azabicyclo[2.2.2]octan-3-yl acetate 3-Quinuclidinol acetate ester 3-Quinuclidinyl acetate (3R)-1-Azabicyclo[2.2.2]oct-3-yl acetate Aceclidine 1-Azabicyclo[2.2.2]octan-3-ol, 3-acetate NSC 657843 NSC657843 NSC-657843 827-61-2