CF53
- CAS No.
- 1808160-52-2
- Chemical Name:
- CF53
- Synonyms
- CF53;CF-53,CF53;CF53, 10 mM in DMSO;9H-Pyrimido[4,5-b]indol-4-amine, N-(3-cyclopropyl-1-methyl-1H-pyrazol-5-yl)-7-(3,5-dimethyl-4-isoxazolyl)-6-methoxy-2-methyl-
- CBNumber:
- CB65419706
- Molecular Formula:
- C24H25N7O2
- Molecular Weight:
- 443.5
- MDL Number:
- MFCD31807607
- MOL File:
- 1808160-52-2.mol
CF53 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0047695 | CF53 98.94% | 1808160-52-2 | 5mg | $450 | 2021-12-16 | Buy |
| ChemScene | CS-0047695 | CF53 98.94% | 1808160-52-2 | 10mg | $750 | 2021-12-16 | Buy |
| ChemScene | CS-0047695 | CF53 98.94% | 1808160-52-2 | 50mg | $2250 | 2021-12-16 | Buy |
| ChemScene | CS-0047695 | CF53 98.94% | 1808160-52-2 | 100mg | $3350 | 2021-12-16 | Buy |
CF53 Chemical Properties,Uses,Production
Uses
CF53 is a highly potent, selective and orally active inhibitor of BET protein, with a Ki of <1 nM, Kd of 2.2 nM and an IC50 of 2 nM for BRD4 BD1. CF53 binds to both the BD1 and BD2 domains of BRD2, BRD3, BRD4, and BRDT BET proteins with high affinities, very selective over non-BET bromodomain-containing proteins. CF53 shows potent anti-tumor activity both in vitro and in vivo[1].
in vivo
CF53 (25, 50 mg/kg, p.o.) exhibits potent anti-tumor activity both in MDA-MB-231 xenograft tumor model and in RS4;11 model in mice[1].
IC 50
BRD4 (BD1): <1 nM (Ki); BRD4 (BD1): 2 nM (IC50); BRD4 (BD1): 2.2 nM (Kd); BRD4 (BD2): 0.8 nM (Kd); BRD2 (BD2): 0.6 nM (Kd); BRD2 (BD1): 1.1 nM (Kd); BRD3 (BD2): 0.49 nM (Kd); BRD3 (BD1): 0.52 nM (Kd); BRDT (BD2): 1 nM (Kd); BRDT (BD1): 2 nM (Kd); CECR2: 570 nM (Kd)
References
[1] Zhao Y, et al. Structure-Based Discovery of CF53 as a Potent and Orally Bioavailable Bromodomain and Extra-Terminal (BET) Bromodomain Inhibitor. J Med Chem. 2018 Jul 26;61(14):6110-6120. DOI:10.1021/acs.jmedchem.8b00483
CF53 Preparation Products And Raw materials
Raw materials
Preparation Products
CF53 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32376 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38838 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 12952 | 65 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7786 | 56 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9729 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| Shanghai hongqu biomedical technology co. LTD | 88888888888 | hongquchem@qq.com | China | 5132 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24982 | 58 |
