SERCA2a activator A
- CAS No.
- 2139330-34-8
- Chemical Name:
- SERCA2a activator A
- Synonyms
- SERCA2a activator A;SERCA2a activator 1;[2,3'-Bipyridine]-4-carboxamide, 1'-butyl-1',6'-dihydro-N-(2-naphthalenylsulfonyl)-6'-oxo-5'-(phenylmethyl)-;Ca channels,phospholamban,Inhibitor,Ca2+ channels,SERCA2a activator 1,SERCA2a,SERCA-2a activator 1,failure,reticulum,Calcium Channel,Ca2+,sarcoplasmic,diastolic,heart,systolic,inhibit
- CBNumber:
- CB65867480
- Molecular Formula:
- C32H29N3O4S
- Molecular Weight:
- 551.66
- MDL Number:
- MFCD34469372
- MOL File:
- 2139330-34-8.mol
SERCA2a activator A Chemical Properties,Uses,Production
Biological Activity
SERCA2a activator 1 (Compound A) is a sarco/endoplasmic reticulum Ca2+-dependent ATPase 2a (SERCA2a) activator. SERCA2a activator 1 attenuates phospholamban inhibition and enhances the systolic and diastolic functions of the heart. SERCA2a activator 1 can be used for heart failure[1]. SERCA2a activator 1 (Compound A) activates the Ca2+-dependent ATPase activity of cardiac sarcoplasmic reticulum (SR) vesicles but not that of skeletal muscle SR vesicles that lack phospholamban (PLN). The surface plasmon resonance assay reveals a direct interaction between SERCA2a activator 1 and PLN, suggesting that the binding of SERCA2a activator 1 to PLN attenuates its inhibition of SERCA2a, resulting in SERCA2a activation[1]. SERCA2a activator 1 also increases the Ca2+ transients and contraction and relaxation of isolated adult rat cardiomyocytes. In isolated perfused rat hearts, the SERCA2a activator 1 enhances systolic and diastolic functions[1]. SERCA2a activator 1 (Compound A; 30mg/kg; intravenous injection; male Wistar rats) treatment significantly enhances the diastolic function in anesthetized normal rats[1].
References
[1]. Kaneko M, et al. A pyridone derivative activates SERCA2a by attenuating the inhibitory effect of phospholamban. Eur J Pharmacol. 2017 Nov 5;814:1-8.
SERCA2a activator A Preparation Products And Raw materials
Raw materials
Preparation Products
SERCA2a activator A Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 3697 | 58 |
| Hebei Weite Medical Technology Co., Ltd | 13180081292 | contact@wetogethermed.com | China | 7289 | 58 |
| Nantong Hi-Future Biotechnology Co., Ltd | 18051384581 | sales@chemhifuture.com | China | 3063 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24024 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | 024-024-88590548 18341751992 | 757984502@qq.com | China | 888 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9146 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 12007 | 58 |