ChemicalBook >> CAS DataBase List >>Cyclohexanecarboxamide, 4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]-
Cyclohexanecarboxamide, 4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]-
- CAS No.
- 104676-09-7
- Chemical Name:
- Cyclohexanecarboxamide, 4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]-
- Synonyms
- Cyclohexanecarboxamide, 4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]-
- CBNumber:
- CB66193180
- Molecular Formula:
- C12H16N2O3
- Molecular Weight:
- 236.27
- MDL Number:
- MFCD33023408
- MOL File:
- 104676-09-7.mol
Last updated:2024-03-27 16:40:14
Cyclohexanecarboxamide, 4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]- Chemical Properties,Uses,Production
Biological Activity
MCC is non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs), such as MCC-DM1[1]. Antibody-drug conjugates (ADCs) are potent cytotoxic drugs linked to antibodies through chemical linkers, and allow specific targeting of drugs to neoplastic cells. Anti-CD22-MCC-DM1 is broadly effective in vitro against multiple NHL cell lines[1].
References
[1]. Polson AG, et al. Anti-CD22-MCC-DM1: an antibody-drug conjugate with a stable linker for the treatment of non-Hodgkin's lymphoma. Leukemia. 2010;24(9):1566-1573.
Cyclohexanecarboxamide, 4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
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Cyclohexanecarboxamide, 4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]-
104676-09-7