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Phentolamine structure
Chemical Name:
Molecular Formula:
Formula Weight:
MOL File:

Phentolamine Properties

Melting point:
Boiling point:
424.02°C (rough estimate)
1.0510 (rough estimate)
refractive index 
1.6500 (estimate)
pKa 7.7 (Uncertain)
CAS DataBase Reference
50-60-2(CAS DataBase Reference)


Hazardous Substances Data 50-60-2(Hazardous Substances Data)

Phentolamine price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy

Phentolamine Chemical Properties,Uses,Production




ChEBI: A substituted aniline that is 3-aminophenol in which the hydrogens of the amino group are replaced by 4-methylphenyl and 4,5-dihydro-1H-imidazol-2-ylmethyl groups respectively. An alpha-adrenergic antagonist, it is used fo the treatment of hypertension.


Human erectile tissue has a population of membrane receptors that are predominantly of the -adrenoceptor subtype. Phentolamine (Vasomax) is a nonselective - adrenoceptor blocking agent (see Chapter 11), and like other such agents, it has been used to treat ED. Nonselective adrenoceptor antagonists may provoke a reflex that increases both sympathetic outflow and the release of norepinephrine.

brand name

Regitine (Novartis) [Name previously used: Phentolamine Methanesulfonate.].

General Description

Phentolamine isthe more effectiveα -blocker.

Clinical Use

Phentolamine isused to prevent or control hypertensive episodes that occurin patients with pheochromocytoma. It also has been used incombination with papaverine to treat impotence.

Clinical Use

Phentolamine has been used orally and intracavernosally in the treatment of ED. Following oral administration, phentolamine has a plasma half-life of about 30 minutes and a duration of action of 2 to 4 hours. An intracavernosal injection of phentolamine results in the drug reaching maximum serum levels in about 20 to 30 minutes. It is rapidly metabolized. Phentolamine has been used in combination with papaverine, chlorpromazine, and vasoactive peptides in the treatment of ED.

Side effects

Side effects of phentolamine are dose related. It may cause orthostatic hypotension, reflex tachycardia, cardiac arrhythmias, and rarely, myocardial infarction. Phentolamine also may reduce sperm motility in vitro.

Enzyme inhibitor

This versatile nonselective a-adrenergic receptor antagonist (FWfree-base = 281.36 g/mol; CAS 50-60-2 (free base), 65-28-1 (mesylate salt), and 73-05- 2 (mono-HCl salt, which is slightly soluble in water (1 g/ 50 mL water) ), known systematically as 3-[4,5-dihydro-1H-imidazol-2-ylmethyl- (4- methylphenyl) amino]phenol, has been used to treat hypertension, hypertensive emergencies, pheochromocytoma, vasospasm associated with Reynaud’s Disorder and frostbite. The methanesulfonate salt is also known as Regitine?. Note: Aqueous solutions are unstable and must be freshly prepared and cannot be stored. Target (s) : a-adrenergic receptor; K+- channels, ATP-sensitive, or KATP channels); and protein kinase C.

Phentolamine Preparation Products And Raw materials

Raw materials

Preparation Products

Phentolamine Suppliers

Global( 62)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 21914 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20680 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32457 55
career henan chemical co
+86-371-86658258 CHINA 20602 58
LGM Pharma 1-(800)-881-8210
615-250-9817 United States 1943 70
Jinan Haohua Industry Co., Ltd 0531-58773082 ;58773060
0531-58773099 China 5587 58
Beijing HuaMeiHuLiBiological Chemical 010-56205725;010-86181995
010-65763397 China 12343 58
(CSR Factory)China Skyrun Industrial CO.,ltd Please Email China 12128 58
Chengdu HuaXia Chemical Reagent Co. Ltd 400-1166-196 18981987031
028-84555506 QQ:800101999 China 9970 58
Shanghai Kewel Chemical Co., Ltd. +86 (21) 6460-9169
+86 (21) 6460-9160 China 9818 50

View Lastest Price from Phentolamine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-20 Phentolamine
US $1.00 / KG 1G 98% 100KG career henan chemical co

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  • API
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