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ISOFENPHOS

ISOFENPHOS
ISOFENPHOS structure
CAS No.
25311-71-1
Chemical Name:
ISOFENPHOS
Synonyms
40sd;Amaze;pyrfon;discus;le-mat;Pryfon;OFTANOL;B-92114;AMAZE(R);sra12869
CBNumber:
CB6667609
Molecular Formula:
C15H24NO4PS
Formula Weight:
345.39
MOL File:
25311-71-1.mol

ISOFENPHOS Properties

Melting point:
-12℃
Boiling point:
bp0.01 120°
Density 
1.131 g/cm3 (20 ºC)
storage temp. 
0-6°C
CAS DataBase Reference
25311-71-1(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T,N,Xn,F
Risk Statements  24/25-50/53-52/53-36-20/21/22-11
Safety Statements  36/37-45-60-61-26-16
RIDADR  3018
WGK Germany  2
RTECS  VO4395500
HazardClass  6.1(a)
PackingGroup  I
HS Code  29299090
Toxicity LD50 orally in rats, mice (mg/kg): 30-40, 90-130 (Homeyer)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H412 Harmful to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 3 P273, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

ISOFENPHOS price

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ISOFENPHOS Chemical Properties,Uses,Production

Chemical Properties

Isofenphos is a colorless oil at room temperature. It is sparingly soluble in water, but soluble in cyclohexone, toluene, acetone, and diethyl ether. The US EPA has grouped isofenphos under RUP, which indicates that qualifi ed, certifi ed, and trained workers are required in the safety management of isofenphos. It is used on turf and ornamental trees and shrubs to control white grubs, mole crickets, and other insects, such as soil-dwelling insects, cabbage root fl ies, corn roundworms, and wire worms.

Uses

Isofenphos is an organophosphorus insecticide used in soil to control leaf-eating and soil-dwelling pests in vegetables, fruits, turf and field crops.

Uses

Insecticide.

General Description

Colorless oil. Non corrosive. Used as an insecticide.

Air & Water Reactions

Hydrolyzed by alkali solution.

Reactivity Profile

Organothiophosphates, such as ISOFENPHOS, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.

Health Hazard

Exposures to isofenphos are highly toxic to animals and humans. Acute and prolonged exposures to high concentrations of isofenphos has caused poisoning with symptoms such as increased secretions, diffi culty in breathing, diarrhea, urination, pupil contraction, slowness of the heart, convulsions, and coma. Isofenphos in combination with malathion cause severe poisoning in humans.

Health Hazard

Exposures to isofenphos are highly toxic to animals and humans. Acute and prolonged exposures to high concentrations of isofenphos has caused poisoning with symptoms such as increased secretions, diffi culty in breathing, diarrhea, urination, pupil contraction, slowness of the heart, convulsions, and coma. Isofenphos in combination with malathion cause severe poisoning in humans.In 1990, an outbreak in the north of England, involving a large number of pigs, consumption of contaminated feed, and development of ataxia, has suggested that isofenphos causes delayed neuropathy. In view of the hazards and based on the requests of the manufacturers, the US EPA indicated the proposals to phase out isofenphos. Studies have indicated that isofenphos is not mutagenic, teratogenic, or carcinogenic to animals and humans.

Environmental Fate

Soil. Rapidly degraded by microbes via oxidative desulfuration in soils forming isofenphos oxon (Abou-Assaf et al., 1986; Abou-Assaf and Coats, 1987; Somasundarum et al., 1989), isopropyl salicylate and carbon dioxide (Somasundaram et al., 1989). The formation of isofenphos oxon is largely dependent upon the pH, moisture and temperature of the soil. The degradation rate of isofenphos decreased with a decrease in temperature (35°C >25°C >15°C), moisture content (22.5% >30% >15%) and in acidic and alkaline soils (pH 6 and 8 >pH 7). After isofenphos was applied to soil at a rate of 1,12 kg/ai/ha, concentrations of 8.3, 7.2, 5.1 and 1.0 ppm were found after 5, 21, 43 and 69 days, respectively. Following a second application, 4.9, 1.55, 0.25 and 0.10 ppm of isofenphos were found after 5, 21, 43 and 69 days, respectively (Abou-Assaf and Coats, 1987).
A pure culture of Arthrobacter sp. was capable of degrading isofenphos at different soil concentrations (10, 50 and 100 ppm) in less than 6 hours. In previously treated soils,isofenphos could be mineralized to carbon dioxide by indigenous microorganisms (
Plant. Two weeks following application to thatch, 65% of the applied amount was present (Sears et al., 1987).
Surface Water. In estuarine water, the half-life of isofenphos ranged from 9.8 to 11.9 days (Lacorte et al., 1995).
Photolytic. Irradiation of an isofenphos (500 mg) in hexane and methanol (100 mL) using a high pressure mercury lamp (l = 254–360 nm) for 24 hours yielded the following products: isofenphos oxon and O-ethyl hydrogen-N-isopropylphosphoroamidothioa

Metabolic pathway

14C-Isofenphos is bioactivated by mixed-function oxidases that ultimately give N-desisopropylisofenphos oxon, a product with 2300-fold greater inhibitory potency than isofenphos oxon towards housefly head acetylcholinesterase.271 By housefly and the cuperous chafer, isofenphos is metabolized to give detoxified metabolites without the bioactivated N- desisopropylisofenphos oxon. No difference in kinds of metabolite is found between the two insects. When rats are administered 14C-isofenphos, most of the radioactivity is recovered from the water fraction of the urine and feces. Aminoisofenphos and isofenphos oxon are detected in the benzene fraction, and the other six metabolites are identified as water-soluble metabolites which include O-ethylhydrogen phosphoramidate and O-ethylhydrogen isopropylphosphoramidothioate. Water-soluble metabolites are predominantly formed through cleavage of the P-O-aryl linkage.

ISOFENPHOS Preparation Products And Raw materials

Raw materials

Preparation Products


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