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2-Bromo-2′-hydroxyacetophenone

2-Bromo-2′-hydroxyacetophenone structure

CAS No.: 2491-36-3

Chemical Name:: 2-Bromo-2′-hydroxyacetophenone

Synonyms: 2-AMINO-3'2-Bromo-2′Cyclohexane Impurity 4;2-HYDROXYPHENACYL BROMIDE;2-BROMO-2'-HYDROXYACETOPHENONE;2-Bromo-2’-hydroxyacetophenone;2-Bromo-2'-hydroxylacetophenone;2-(2-bromoacetyl)hydroxybenzene;2-Bromo-2'-hydroxyacetophenone 97%;2-Bromo-2'-hydroxyacetophenone ,97%

CBNumber:: CB6675345

Molecular Formula:: C8H7BrO2

Molecular Weight:: 215.04

MDL Number:: MFCD01727570

MOL File:: 2491-36-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:56:55

Product description	Number	Pack Size	Price
2-Bromo-2′-hydroxyacetophenone 97%	594938	1g	$70.5
2-Bromo-2′-hydroxyacetophenone 97%	594938	5g	$137
2-Bromo-2'-hydroxyacetophenone	B4735	1G	$60
2-Bromo-2'-hydroxyacetophenone	B4735	5G	$181
2-Bromo-2’-hydroxyacetophenone	B684455	1g	$205

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2-Bromo-2′-hydroxyacetophenone Properties

Melting point	44-48 °C(lit.)
Boiling point	152-158 °C(Press: 18 Torr)
Density	1.622±0.06 g/cm3(Predicted)
Flash point	>230 °F
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	Chloroform, Methanol
pka	7.63±0.30(Predicted)
form	Solid
color	Yellow
Sensitive	Lachrymatory
InChI	1S/C8H7BrO2/c9-5-8(11)6-3-1-2-4-7(6)10/h1-4,10H,5H2
InChIKey	SGPKEYSZPHMVNI-UHFFFAOYSA-N
SMILES	Oc1ccccc1C(=O)CBr
CAS DataBase Reference	2491-36-3(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07

Signal word

Danger

Hazard statements

H302-H314

Precautionary statements

P260-P270-P280-P301+P312-P303+P361+P353-P305+P351+P338

PPE

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Hazard Codes

Risk Statements

22-34

Safety Statements

26-36/37/39-45

RIDADR

UN 3263 8/PG 2

WGK Germany

RTECS

KM5556400

Hazard Note

Corrosive/Lachrymatory/Keep Cold

HazardClass

PackingGroup

HS Code

29147000

Storage Class

8A - Combustible corrosive hazardous materials

Hazard Classifications

Acute Tox. 4 Oral
Skin Corr. 1B

Toxicity

mouse,LD50,oral,821mg/kg (821mg/kg),BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)LUNGS, THORAX, OR RESPIRATION: DYSPNEABEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD,Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 1, Pg. 183, 1992.

Limited Quantities

1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)

NFPA 704

	1
3		0

2-Bromo-2′-hydroxyacetophenone price More Price(31)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	594938	2-Bromo-2′-hydroxyacetophenone 97%	2491-36-3	1g	$70.5	2022-05-15	Buy
Sigma-Aldrich	594938	2-Bromo-2′-hydroxyacetophenone 97%	2491-36-3	5g	$137	2022-05-15	Buy
TCI Chemical	B4735	2-Bromo-2'-hydroxyacetophenone	2491-36-3	1G	$60	2026-04-30	Buy
TCI Chemical	B4735	2-Bromo-2'-hydroxyacetophenone	2491-36-3	5G	$181	2026-04-30	Buy
TRC	B684455	2-Bromo-2’-hydroxyacetophenone	2491-36-3	1g	$205	2021-12-16	Buy

Product number	Packaging	Price	Buy
594938	1g	$70.5	Buy
594938	5g	$137	Buy
B4735	1G	$60	Buy
B4735	5G	$181	Buy
B684455	1g	$205	Buy

2-Bromo-2′-hydroxyacetophenone Chemical Properties,Uses,Production

Chemical Properties

Off-White Powder

Uses

2-Bromo-2′-hydroxyacetophenone is used as a pharmaceutical intermediate.

Synthesis

118-93-4

2491-36-3

The general procedure for the synthesis of 2-bromo-1-(2-hydroxyphenyl)ethanone from 2'-hydroxyacetophenone is as follows: in a 50 mL round-bottomed flask equipped with a magnetic stirrer, 2'-hydroxyacetophenone (10 mmol) was added. Subsequently, potassium bromide (40 mmol) dissolved in 20 mL of water was added to this solution and mixed with stirring at room temperature. Next, 30% hydrogen peroxide (4 mmol) was slowly added. Vanadium (V) complex (0.01 mmol) and 70% perchloric acid (4 mmol) were further added to the reaction system, and the reaction mixture was stirred at 0°C, followed by raising to room temperature and continued stirring for 10 minutes. Under continuous stirring conditions, additional 70% perchloric acid (4 mmol) was added every 10 min for three times. The reaction process was monitored by thin layer chromatography (TLC). The nuclear magnetic resonance (NMR) spectral data of the final brominated product is detailed in the Supporting Information.

References

[1] Tetrahedron Letters, 2009, vol. 50, # 6, p. 700 - 703
[2] Tetrahedron, 2001, vol. 57, # 11, p. 2203 - 2211
[3] Archiv der Pharmazie, 2009, vol. 342, # 9, p. 541 - 545
[4] Synthetic Communications, 2006, vol. 36, # 19, p. 2877 - 2881
[5] Journal of Organometallic Chemistry, 2018, vol. 876, p. 10 - 16

2-Bromo-2′-hydroxyacetophenone synthesis

Synthesis of 2-Bromo-2′-hydroxyacetophenone from 2-HYDROXYACETOPHENONE

2-Bromo-2′-hydroxyacetophenone Preparation Products And Raw materials

Raw materials

Bromine Acetic acid 2'-Hydroxyacetophenone Ethanone, 1-[2-(acetyloxy)phenyl]-2-bromo- Phenyl bromoacetate

Potassium bromide PERCHLORIC ACID Hydrogen peroxide 2-HYDROXYACETOPHENONE Phenol

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Preparation Products

5-Bromo-2-hydroxyacetophenone 2-Bromo-4'-hydroxyacetophenone 2-BROMO-1-(5-BROMO-2-HYDROXYPHENYL)ETHANONE 3-(BROMOMETHYL)-1,2-BENZISOXAZOLE 2-BROMO-1-(2-HYDROXY-5-NITRO-PHENYL)-ETHANONE

2-Bromo-2′-hydroxyacetophenone Suppliers

Global( 151)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	contact@fuxinpharm.com	China	10000	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Win-Win chemical CO., Limited	+86-0086-577-64498589 +86-15355981851	sales@win-winchemical.com	China	14304	58
Alfa Chemistry		info@alfa-chemistry.com	United States	2344	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52705	58
sgtlifesciences pvt ltd	+8617013299288	dj@sgtlifesciences.com	China	12373	58
RR Scientific LLC	+86-13917743231	sales@rrscientific.com	United States	878	58
GLR Innovations	+91 9891111994	info@glrgroup.in	India	4535	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850	market18@leapchem.com	China	24597	58

Supplier	Advantage
CONIER CHEM AND PHARMA LIMITED	58
Fuxin Pharmaceutical	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Win-Win chemical CO., Limited	58
Alfa Chemistry	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
sgtlifesciences pvt ltd	58
RR Scientific LLC	58
GLR Innovations	58
HANGZHOU LEAP CHEM CO., LTD.	58

View Lastest Price from 2-Bromo-2′-hydroxyacetophenone manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-12-01	2-Bromo-2′-hydroxyacetophenone 2491-36-3	US $0.00 / kg	1kg	99%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
	2025-04-04	2-BROMO-2'-HYDROXYACETOPHENONE 2491-36-3	US $0.00-0.00 / kg	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.

2-Bromo-2′-hydroxyacetophenone
2491-36-3
US $0.00 / kg
99%
Shaanxi Dideu New Materials Co. Ltd

2-BROMO-2'-HYDROXYACETOPHENONE
2491-36-3
US $0.00-0.00 / kg
98%
Henan Aochuang Chemical Co.,Ltd.

2-Bromo-2′-hydroxyacetophenone Spectrum

2-Bromo-2′-hydroxyacetophenone(2491-36-3)¹HNMR

2491-36-3(2-Bromo-2′-hydroxyacetophenone)Related Search:

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3'-BROMO-4'-HYDROXYACETOPHENONE 2,3-DIBROMO-1-(5-CHLORO-2-HYDROXYPHENYL)-3-PHENYLPROPAN-1-ONE 2-BROMO-2,3-DIHYDRO-4,7-DIMETHOXY-1H-INDEN-1-ONE

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2-Bromo-2'-hydroxyacetophenone ,97% 2-Bromo-2'-hydroxyacetophenone, 2-Bromo-1-(2-hydroxyphenyl)ethan-1-one, 2-(Bromoacetyl)phenol 2-broMo-1-(2-hydroxyphenyl)ethan-1-one 2-Bromo-2'-hydroxyacetophenone 97% 2-bromo-1-(2-hydroxyphenyl)-ethanon 2-HYDROXYPHENACYL BROMIDE 2-BROMO-1-(2-HYDROXYPHENYL)ETHANONE 2-BROMO-2'-HYDROXYACETOPHENONE 2-Bromo-2'-hydroxylacetophenone JR-8498, 2-Bromo-1-(2-hydroxyphenyl)ethanone, 97% Ethanone, 2-bromo-1-(2-hydroxyphenyl)- 2-(2-bromoacetyl)hydroxybenzene 2-AMINO-3' 2-Bromo-2’-hydroxyacetophenone 2-Bromo-2′ Cyclohexane Impurity 4 2491-36-3 BrCH2COC6H4OH Organic Building Blocks Ketones Building Blocks C7 to C8 Carbonyl Compounds Intermediate of Neticonazole Hydrochloride API intermediates Aromatics C7 to C8 Carbonyl Compounds Ketones