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APHIDICOLIN

APHIDICOLIN
APHIDICOLIN structure
CAS No.
38966-21-1
Chemical Name:
APHIDICOLIN
Synonyms
APC;ici69653;nsc-234714;APHIDICOLIN;(+)-APHIDICOLIN;,11a-beta,11b-beta))-;Aphidicolin, Ready Made Solution;(+)-APHIDICOLIN, NIGROSPORA ORYZAE;Aphidicolin, froM Nigrospora oryzae;APHIDICOLIN FROM NIGROSPORA SPHAERICA
CBNumber:
CB6683304
Molecular Formula:
C20H34O4
Formula Weight:
338.48
MOL File:
38966-21-1.mol

APHIDICOLIN Properties

Melting point:
218-220°C
alpha 
D27 +12° (c = 1 in methanol)
Boiling point:
394.61°C (rough estimate)
Density 
1.0057 (rough estimate)
vapor pressure 
0.55 hPa ( 20 °C)
refractive index 
1.4434 (estimate)
Flash point:
87℃
storage temp. 
2-8°C
solubility 
ethanol: soluble1mg/mL (stable at least a week at 4°C.)
form 
White solid
color 
colorless
optical activity
[α]27/D +12°, c = 1 in methanol(lit.)
Water Solubility 
Soluble in DMSO or methanol. Insoluble in water. Store solutions at -20°
Merck 
13,734
BRN 
4689958

SAFETY

Safety Statements  22-24
RIDADR  NA 1993 / PGIII
WGK Germany  3
RTECS  PB9185000
10-21
HS Code  29419090

APHIDICOLIN price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 178273 Aphidicolin 38966-21-1 1mg $109 2018-11-20 Buy
Sigma-Aldrich 89458 Aphidicolin analytical standard 38966-21-1 5mg $823 2018-11-20 Buy
Alfa Aesar J60236 Aphidicolin 38966-21-1 1mg $168 2018-11-13 Buy
Alfa Aesar J60236 Aphidicolin 38966-21-1 5mg $472 2018-11-13 Buy
Cayman Chemical 14007 (+)-Aphidicolin ≥98% 38966-21-1 5mg $220 2018-11-13 Buy

APHIDICOLIN Chemical Properties,Uses,Production

Chemical Properties

White crystal

Uses

(+)-Aphidicolin is a naturally occurring tetracyclic diterpene with potential antiviral and antimitotical properties.

Uses

Aphidicolin is a tetracyclic diterpene antibiotic isolated from fungi, notably Cephalosporium, Nigrospora, Harziella and Phoma. Aphidicolin has antibiotic, antiviral and antimitotic properties, blocking the cell cycle at early S-phase. This property has been used to synchronise cell division and is useful as a tool in cell differentiation research. Aphidicolin is a reversible inhibitor of DNA replication by inhibiting selected DNA polymerases. Aphidicolin induces apoptosis, prolongs the half-life of DNA methyltransferase, is active against Leishmania parasites and acts synergistically with the antitumour agents, vincristine and doxorubicin.

Uses

Aphidicolin is a tetracyclic diterpene antibiotic isolated from fungi, notably Cephalosporium, Nigrospora, Harziella and Phoma. Aphidicolin has antibiotic, antiviral and antimitotic properties, blocking the cell cycle at early S-phase. This property has been used to synchronise cell division and is useful as a tool in cell differentiation research. Aphidicolin is a reversible inhibitor of DNA replication by inhibiting selected DNA polymerases. Aphidicolin induces apoptosis, prolongs the half-life of DNA methyltransferase, is active against Leishmania parasites and acts synergistically with the antitumor agents, vincristine and doxorubicin.

Definition

ChEBI: A tetracyclic diterpenoid that has an tetradecahydro-8,11a-methanocyclohepta[a]naphthalene skeleton with two hydroxymethyl substituents at positions 4 and 9, two methyl substituents at positions 4 and 11b and two hydroxy substituents at positi ns 3 and 9. An antibiotic with antiviral and antimitotical properties. Aphidicolin is a reversible inhibitor of eukaryotic nuclear DNA replication.

Enzyme inhibitor

This photosensitive diterpenoid (FW = 338.49 g/mol; CAS 38966-21-1; M.P. = 227–232°C; IUPAC: (3R,4R,4aR,6aS,8R,9R,11aS,11bS)tetradeca hydro-3,9-dihydroxy-4,11b-dimethyl-8,11a-methano-11aH-cyclohepta[a] naphthalene-4,9-dimethanol) from Cephalosporium aphidicola and Nigrospora oryzae inhibits many nuclear replicative DNA polymerases, thereby arresting the cell cycle in the S phase. Inhibition of DNA polymerase a is noncompetitive with respect to dATP, dGTP, dTTP as well as DNA, but is competitive relative to dCTP. Certain cells become aphidicolin-resistant by any one of the following adaptations: (a) a mutation in DNA polymerase a that greatly decreases affinity for the drug; (b) overproduction of DNA polymerase a; or (c) increased synthesis of dCTP. Replication of mitochondrial and chloroplast DNA is unaffected by aphidicolin. Target(s): DNA polymerase a; f29 DNA polymerase; DNA polymerase d (3,6,7,8,21- 23,26,27,29,32); DNA polymerase z; bacteriophage T4 DNA polymerase; DNA polymerase e; Pyrococcus furiosus DNA polymerase BI; Herpes simplex-induced DNA polymerase; Vaccinia-induced DNA polymerase; plant cell a-like DNA polymerase; yeast DNA polymerase I; yeast DNA polymerase II.

APHIDICOLIN Preparation Products And Raw materials

Raw materials

Preparation Products


APHIDICOLIN Suppliers

Global( 68)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Wuhan Chemwish Technology Co., Ltd 86-027-67849912
86-027-87531808 sales@chemwish.com China 35911 56
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. +86-21-54098501
+86-21-54096319 sales@sinch.com.cn China 11609 64
Shanghai Aladdin Bio-Chem Technology Co.,LTD 021-20337333/400-620-6333
021-50323701 sale@aladdin-e.com China 24991 65
Guangzhou Isun Pharmaceutical Co., Ltd 020-39119399 18927568969
020-39119999 isunpharm@qq.com, isunpharm@hotmail.com China 5020 55
ChemStrong Scientific Co.,Ltd 0755 66853366
0755 28363542 sales@chem-strong.com; China 15618 56
Sigma-Aldrich 021-61415566 800-819-3336(Tel) 400-620-3333(Mobile)
orderCN@merckgroup.com China 28681 80
Codow Chemical Co.,Ltd. +86-20-38056109
+86-20-62619665 sales@howeipharm.com China 18340 55
Henan CoreyChem Co., Ltd 0371-86658258
0371-60996044 info@coreychem.com China 10464 58
Shanghai Xilong Biochemical Technology Co., Ltd. 021-52907766-8042
021-52906523 order@drmaolab.com China 9972 58

38966-21-1(APHIDICOLIN)Related Search:


  • InSolution Aphidicolin - CAS 38966-21-1 - Calbiochem
  • Aphidicolin - CAS 38966-21-1 - Calbiochem
  • APHIDICOLIN FROM CEPHALOSPORIUM APHIDICO LA
  • APHIDICOLIN FROM NIGROSPORA SPHAERICA
  • 8,11a-Methano-11aH-cycloheptaanaphthalene-4,9-dimethanol, tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-, (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-
  • Aphidicolin, froM Nigrospora oryzae
  • Aphidicolin NSC 234714 ICI 69653
  • Aphidicolin, Ready Made Solution
  • 8,11|á-Methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol,tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-, (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-
  • Aphidicolin, 98%, from Nigrospora oryzae
  • (3-ALPHA,4-ALPHA,5-ALPHA,17-ALPHA)-3,17-DIHYDROXY-4-METHYL-9,15-CYCLO-C,18-DINOR-14,15-SECOANDROSTANE-4,17-DIMETHANOL
  • (+)-APHIDICOLIN
  • APHIDICOLIN
  • (+)-APHIDICOLIN, NIGROSPORA ORYZAE
  • APC
  • Di-Terpenoids
  • antibiotic
  • ,11a-beta,11b-beta))-
  • 9-dimethanol,tetradecahydro-3,9-11a-methano-11ah-cyclohepta(a)naphthalene-4
  • dihydroxy-4,11b-dimethyl-,(3r-(3-alpha,4-alpha,4a-alpha,6a-beta,8-beta,9-beta
  • ici69653
  • nsc-234714
  • 38966-21-1
  • BioChemical
  • Antibiotics A to Z
  • Antibiotics A-F
  • Antibiotics
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