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PERPHENAZINE

PERPHENAZINE
PERPHENAZINE structure
CAS No.
58-39-9
Chemical Name:
PERPHENAZINE
Synonyms
PZC;F-mon;sch3940;Fentazin;Sch 3940;Trifaron;Trilafon;Trilifan;Decentan;Emesinal
CBNumber:
CB6687009
Molecular Formula:
C21H26ClN3OS
Formula Weight:
403.97
MOL File:
58-39-9.mol

PERPHENAZINE Properties

Melting point:
95-98?C
Boiling point:
bp0.15 214-218°; bp1 278-281°
Density 
1.253
refractive index 
1.6100 (estimate)
storage temp. 
2-8°C
solubility 
Practically insoluble in water, freely soluble in methylene chloride, soluble in ethanol (96 per cent). It dissolves in dilute solutions of hydrochloric acid.
form 
neat
pka
pKa 7.8(H2O,t =24±1) (Uncertain)
Merck 
14,7183
CAS DataBase Reference
58-39-9(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn
Risk Statements  22-43
Safety Statements  28-36/37/39-45
RIDADR  UN 2811 6.1 / PGII
WGK Germany  3
RTECS  TL7175000
HS Code  29349990
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.

PERPHENAZINE price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich P6402 Perphenazine 58-39-9 1g $71.6 2018-11-13 Buy
Sigma-Aldrich 1511000 Perphenazine United States Pharmacopeia (USP) Reference Standard 58-39-9 200mg $348 2018-11-13 Buy
TCI Chemical P1970 Perphenazine >97.0%(HPLC)(T) 58-39-9 5g $88 2018-11-22 Buy
TCI Chemical P1970 Perphenazine >97.0%(HPLC)(T) 58-39-9 25g $306 2018-11-22 Buy
Cayman Chemical 20735 Perphenazine ≥98% 58-39-9 1g $25 2018-11-19 Buy

PERPHENAZINE Chemical Properties,Uses,Production

Chemical Properties

Off-White to Pale Yellow Solid

Uses

immune suppressant, antifungal

Uses

D2 dopamine receptor antagonist; α-adrenergic receptor antagonist and σ-receptor agonist; phenothiazine antipsychotic. Inhibits glutamate dehydrogenase in vitro. Antipsychotic.

Definition

ChEBI: A phenothiazine derivative in which the phenothiazine tricycle carries a chloro substituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at N-10.

brand name

Trilafon (Schering).

General Description

Perphenazine, 4-[3-(2-chlorophenothiazine-10-yl)propyl]piperazineethanol; 2-chloro-10-[3-[4-(2-hydroxyethyl)piperazinyl]propyl]phenothiazine(Trilafon), is an effective antipsychotic and antiemetic.

Safety Profile

Poison by ingestion, intravenous, subcutaneous, intraperitoneal, and intramuscular routes. Human systemic effects by intramuscular route: muscle spasms. Experimental teratogenic and reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of SOx, NOx, and cl-.

Enzyme inhibitor

This photosensitive phenothiazine (FWfree-base = 403.98 g/mol; CAS 58-39- 9) is a D2 dopamine receptor antagonist and a s receptor agonist. Perphenazine is insoluble in water and soluble in ethanol (153 mg/mL). Target(s): acetylcholinesterase; Ca2+-dependent ATPase; CYP2D6; D2 dopamine receptor; glutamate dehydrogenase; monoamine oxidase; trypanothione reductase, inhibited by cationic free radicals.

PERPHENAZINE Preparation Products And Raw materials

Raw materials

Preparation Products


PERPHENAZINE Suppliers

Global( 103)Suppliers
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