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Felbamate

Felbamate
Felbamate structure
CAS No.
25451-15-4
Chemical Name:
Felbamate
Synonyms
W-554;Talox;Taloxa;Felbamyl;felbatol;ADD-03055;felbamato;FELBAMATE;Sch-54388;Felbanmate
CBNumber:
CB6689427
Molecular Formula:
C11H14N2O4
Formula Weight:
238.24
MOL File:
25451-15-4.mol

Felbamate Properties

Melting point:
148-1500C
Flash point:
9℃
storage temp. 
Store at RT
solubility 
alcohol: soluble
CAS DataBase Reference
25451-15-4(CAS DataBase Reference)
NIST Chemistry Reference
Felbamate(25451-15-4)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS02,GHS06,GHS08
Signal word  Danger
Hazard statements  H225-H301+H311+H331-H370
Precautionary statements  P210-P260-P280-P301+P310-P311
RIDADR  UN1230 - class 3 - PG 2 - Methanol
WGK Germany  2
RTECS  TZ1070000
HS Code  2924296000
Toxicity LD50 i.p. in mice: 4000 mg/kg (Ludwig et al.)

Felbamate price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich F-029 Felbamate 2.0 mg/mL in methanol, ampule of 1 mL, certified reference material 25451-15-4 029-1ml $105 2018-11-13 Buy
Sigma-Aldrich 1269312 Felbamate United States Pharmacopeia (USP) Reference Standard 25451-15-4 250mg $1220 2018-11-13 Buy
Cayman Chemical 18000 Felbamate ≥98% 25451-15-4 5mg $35 2018-11-13 Buy
Cayman Chemical 18000 Felbamate ≥98% 25451-15-4 10mg $60 2018-11-13 Buy
Sigma-Aldrich F0778 Felbamate 25451-15-4 50mg $438 2018-11-13 Buy

Felbamate Chemical Properties,Uses,Production

Description

Felbamate, characterized by its low toxicity and wide margin of safety, is efficacious in treating refractory patients with generalized tonic-clonic and complex partial seizures as monotherapy and adjunctive therapy.It has also been demonstrated to have a neuroprotective effect in cerebral ischemia and hypoxia. It has been suggested that the mechanism of its anticonvulsant activity is possibly through an interaction with the strychnineinsensitive receptor site on the NMDA receptor complex.

Chemical Properties

White Powder

Originator

Carter-Wallace (U.S.A.)

Uses

Antiepileptic, structurally similar to meprobamate

Definition

ChEBI: The bis(carbamate ester) of 2-phenylpropane-1,3-diol. An anticonvulsant, it is used in the treatment of epilepsy.

brand name

Felbatol

Biological Functions

Felbamate (Felbatol) was introduced with the expectation that it would become a major drug in the treatment of epilepsy. Felbamate exhibited few manifestations of serious toxicity in early clinical trials. Soon after its introduction, however, it became apparent that its use was associated with a high incidence of aplastic anemia. Consequently, felbamate is indicated only for patients whose epilepsy is so severe that the risk of aplastic anemia is considered acceptable.
While its mechanism of action has not been clearly established, felbamate shows some activity as an inhibitor of voltage-dependent sodium channels in a manner similar to that of phenytoin and carbamazepine. Felbamate also interacts at the strychnine-insensitive glycine recognition site on the NMDA receptor– ionophore complex.Whether this effect is important to its anticonvulsant activity is not clear.

Hazard

Low toxicity by ingestion. Human systemic effects.

Biological Activity

Anticonvulsant, acting as an antagonist at the NMDA-associated glycine binding site.

Veterinary Drugs and Treatments

Felbamate is an anticonvulsant agent that may useful for treating seizure disorders (especially complex partial seizures) in dogs. A potential advantage of felbamate therapy is that when used alone or in combination with phenobarbital and/or bromides, it does not appear to cause additive sedation.

Felbamate Preparation Products And Raw materials

Raw materials

Preparation Products


Felbamate Suppliers

Global( 149)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2543 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24191 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30002 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23980 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6372 58
BOC Sciences
1-631-619-7922
1-631-614-7828 inquiry@bocsci.com United States 20115 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 35440 58
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63729 58
Zhengzhou Saifun Biotechnology Co., Ltd. 022-60688926;18516385487,13203716043
sfpharm@163.com China 60 55

View Lastest Price from Felbamate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-07-09 felbamate
25451-15-4
US $8.80 / KG 1KG 97%-99% 100kg career henan chemical co

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