Z-LEU-ARG-7-AMINO-4-METHYLCOUMARIN
- CAS No.
- 156192-32-4
- Chemical Name:
- Z-LEU-ARG-7-AMINO-4-METHYLCOUMARIN
- Synonyms
- Z-LEU-ARG-AMC;Z-LEU-ARG-AMC HYDROCHLORIDE;Z-LEU-ARG-7-AMINO-4-METHYLCOUMARIN;CBZ-Leu-Arg-AMC hydrochloride salt;Benzyloxycarbonyl-L-leucyl-L-arginine 4-methylcoumaryl-7-amide;L-Argininamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
- CBNumber:
- CB6691323
- Molecular Formula:
- C30H38N6O6
- Molecular Weight:
- 578.66
- MDL Number:
- MFCD07780911
- MOL File:
- 156192-32-4.mol
| Density | 1.31±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at 0-5°C |
| solubility | Soluble in DMSO |
| form | solid |
| pka | 11.13±0.46(Predicted) |
| color | White |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. Protect from light! |
Z-LEU-ARG-7-AMINO-4-METHYLCOUMARIN price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Alfa Aesar | J64082 | Cathepsin K Substrate (fluorogenic) | 156192-32-4 | 10mg | $140 | 2023-06-20 | Buy |
| Alfa Aesar | J64082 | Cathepsin K Substrate (fluorogenic) | 156192-32-4 | 25mg | $307 | 2023-06-20 | Buy |
| Chem-Impex | 04695 | Z-Leu-Arg-AMC·HCl,99% 99% | 156192-32-4 | 5G | $512.51 | 2021-12-16 | Buy |
| Chem-Impex | 04695 | Z-Leu-Arg-AMC·HCl,99% 99% | 156192-32-4 | 250MG | $908.54 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | PEP0009299 | Z-LEU-ARG-AMC-HYDROCHLORIDE 99.00% | 156192-32-4 | 0.1G | $1540 | 2021-12-16 | Buy |
Z-LEU-ARG-7-AMINO-4-METHYLCOUMARIN Chemical Properties,Uses,Production
Description
Z-Leu-Arg-AMC (156192-32-4) is a sensitive Cathepsin K fluorogenic substrate (Km=8μM, kcat/Km=4 x 105 M-1s-1)1-3. It is cleaved more slowly by the following cathepsins (kcat/Km: B (105)4, F (106)4, L (106)4,5, L2/V (104)5, S (105)2,4,5. Also cleaved by malaria parasite proteases berghepain6, vivapain-2 and -37, and falcipain-1, -2, and -36,8,9. Excitation: 365nm, Emission: 440nm.
Uses
A sensitive fluorogenic substrate for cathepsin K
References
Bossard et al. (1996), Proteolytic activity of human osteoclast cathepsin K. Expression, purification, activation, and substrate identification; J. Biol. Chem. 271 12517 Br?mme et al. (1996), Human cathepsin O2, a matrix protein-degrading cysteine protease expressed in osteoclasts. Functional expression of human cathepsin O2 in Spodoptera frugiperda and characterization of the enzyme; J. Biol. Chem. 271 2126 Linnevers et al. (1997), Expression of human cathepsin K in Pichia pastoris and preliminary crystallographic studies of an inhibitor complex; Protein Sci. 6 919 Wang et al. (1998), Human cathepsin F. Molecular cloning, functional expression, tissue localization, and enzymatic characterization; J. Biol. Chem., 273 32000 Br?mme et al. (1999), Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization and chromosomal localization; Biochemistry, 38 2377 Singh et al. (2007), A chimeric cysteine protease of Plasmodium berghei engineered to resemble the Plasmodium falciparum protease falcipain-2; Protein Eng. Des. Sel. 20 171 Na et al. (2004), Identification and biochemical characterization of vivapains, cysteine proteases of the malaria parasite Plasmodium vivax; Biochem. J. 378(Pt2) 529 Goh et al. (2005), Cysteine protease falcipain 1 in Plasmodium falciparum is biochemically distinct from its isozymes; Parasitol. Res. 97 295 Pandey et al. (2004), Independent intramolecular mediators of folding, activity, and inhibition for the Plasmodium falciparum cysteine protease falcipain-2; J. Biol. Chem. 279 3484
Z-LEU-ARG-7-AMINO-4-METHYLCOUMARIN Preparation Products And Raw materials
Raw materials
Preparation Products
Z-LEU-ARG-7-AMINO-4-METHYLCOUMARIN Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing TGpeptide | +86-13347807150 +86-13347807150 | support@tgpeptide.com | China | 3279 | 58 |
| Zhejiang Hangyu API Co., Ltd | +8617531972939 | anna@api-made.com | China | 2944 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| DONBOO AMINO ACID COMPANY | +8613063595538 | donboo@donboo.com | China | 9365 | 58 |
| GL Biochem (Shanghai) Ltd | 21-61263452 13641803416 | ymbetter@glbiochem.com | China | 9981 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696; | info@hanhongsci.com | China | 42982 | 64 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15421 | 60 |
| Nanjing Leon Biological Technology Co., Ltd. | 17705183659 | sales@njleonbiotech.com | China | 5503 | 55 |
| Nanjing Peptide Biotech Ltd. | 025-58361106-805 13082558573 | liugang@njpeptide.com | China | 9961 | 55 |
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 | eric@peptidego.com | China | 6347 | 58 |