SULINDAC SULFONE
- CAS No.
- 59864-04-9
- Chemical Name:
- SULINDAC SULFONE
- Synonyms
- FGN-1;APTOSYN;EXISULIND;SULINDAC SULFONE;Sulindac Impurity 9;Sulindac EP Impurity B;Sulindac sulfone (Exisulind);Sulindac sulfone,Aldose Reductase,inhibit,Exisulind,Inhibitor;(Z)-5-FLUORO-2-METHYL-1[P-(METHYLSULFONYL)BENZYLIDENE]INDENE-3-ACETIC ACID;5-Fluoro-2-methy L-1-((4-(methylsulfonyl)phenyl)methylene)-1H-indene-3-acetic acid
- CBNumber:
- CB6699783
- Molecular Formula:
- C20H17FO4S
- Molecular Weight:
- 372.41
- MDL Number:
- MFCD01317811
- MOL File:
- 59864-04-9.mol
- MSDS File:
- SDS
| Melting point | 201～203℃ |
|---|---|
| storage temp. | RT |
| solubility | DMSO: >25 mg/mL |
| form | solid |
| color | yellow |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week. |
| FDA UNII | K619IIG2R9 |
SULINDAC SULFONE price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S1438 | Sulindac sulfone ≥94% (HPLC), (solid or powder) | 59864-04-9 | 25mg | $461 | 2024-03-01 | Buy |
| Sigma-Aldrich | S1438 | Sulindac sulfone ≥94% (HPLC), (solid or powder) | 59864-04-9 | 5mg | $120 | 2023-06-20 | Buy |
| Cayman Chemical | 16805 | Sulindac sulfone ≥98% | 59864-04-9 | 5mg | $46 | 2024-03-01 | Buy |
| Cayman Chemical | 16805 | Sulindac sulfone ≥98% | 59864-04-9 | 1mg | $31 | 2023-06-20 | Buy |
| Cayman Chemical | 16805 | Sulindac sulfone ≥98% | 59864-04-9 | 10mg | $88 | 2024-03-01 | Buy |
SULINDAC SULFONE Chemical Properties,Uses,Production
Description
Sulindac sulfone (59864-04-9) is a metabolite of the cyclooxygenase inhibitor sulindac that induces apoptosis via inhibition of type 5 phosphodiesterases.1 Sulindac sulfone does not inhibit cyclooxygenase at physiological concentrations but does inhibit K-ras-dependent cyclooxygenase-2 expression in colon cancer cells.2 Modulates beta-catenin mediated effects. 3
Uses
Sulindac Sulfone is an inhibitor of growth and inducer of apoptosis in cancer cell lines.
Biochem/physiol Actions
Sulindac sulfone is non-steroidal anti-inflammatory drug and an analgesic that has antiproliferative and apoptotic effects. It inhibits the expression and activity of cyclooxygenase-2 in human colon cancer cells1,2 and reduces tumor burden in adenomatous polyposis patients.3
in vitro
sulindac sulfone treatment also inhibited pge2 production by hca-7 cells with an ic50 of 360 mmol/l. sulindac sulfone at 100 mmol/l reduced 6-ketopgfα by 29.2%. sulindac sulfone reduced the colony number of hca-7 and hct-116 with an ec50 of 50 mmol/l[1]. sulindac sulfone significantly decreased the expression of total cellular β-catenin (50% of control), pro-caspase 3 (49%), cyclin d1 (51%), and pparδ (65%) in sw480 cells. no significant alteration in pro-caspase 3 or β-catenin expression was found in hca7, ls174, or caco-2 cells treated with sulindac sulfone. a dose-dependent reduction in tcf-mediated transcriptional activity was also observed in sw480 cells [2].
in vivo
sulindac sulfone is capable of reducing the incidence, multiplicity and tumor burden in the azoxymethane aom rat model of colorectal cancer. sulindac sulfone had no effect on the growth of hca-7, hct-116 xenografts and cancer cell xenografts [1].
References
References/Citations 1) Thompson et al. (2000) Exisulind induction of apoptosis involves guanosine 3′,5′-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation and attenuated beta-catenin. Cancer Res., 60 3338 2) Taylor et al. (2000) Sulindac sulfone inhibits K-ras-dependent cyclooxygenase-2 expression in human colon cancer cells; Cancer Res. 60 6607 3) Bravi et al. (2015) Sulindac metabolites decrease cerebrovascular malformations in CCM-3 knockout mice; Proc. Natl. Acad. Sci. USA 112 8421
SULINDAC SULFONE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| China National Standard Pharmaceutical Corporation Limited | +8615391658522 | overseasales@yongstandards.com | China | 11927 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Shanghai Tauto Biotech Co., Ltd. | 021-51320588 | tauto@tautobiotech.com | China | 3989 | 66 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4428 | 55 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Syntechem Co.,Ltd. | 519-88298820 15861130028 | info@syntechem.com | China | 242 | 58 |