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Phenformin

Phenformin
Phenformin structure
CAS No.
114-86-3
Chemical Name:
Phenformin
Synonyms
pbi;w32;Pedg;W 32;Dipar;dbcomb;diabis;dibein;azucaps;debeone
CBNumber:
CB6700560
Molecular Formula:
C10H15N5
Formula Weight:
205.26
MOL File:
114-86-3.mol

Phenformin Properties

Melting point:
176.5 °C
Boiling point:
333.94°C (rough estimate)
Density 
1.0541 (rough estimate)
refractive index 
1.6380 (estimate)
pka
pKa 3.1/12.9±0.01(H2O,t =25,I>0.1) (Uncertain)
CAS DataBase Reference
114-86-3(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
DD5K7529CE
ATC code
A10BA01
NIST Chemistry Reference
Imidodicarbonimidic diamide, n-(2-phenylethyl)-(114-86-3)
SAFETY
  • Risk and Safety Statements
Hazard Codes  Xn
Risk Statements  22
Safety Statements  36
WGK Germany  3
RTECS  DU2200000
Toxicity LD50 orl-rat: 1650 mg/kg BCFAAI 110,470,71

Phenformin Chemical Properties,Uses,Production

Originator

DBI ,Geigy, US ,1959

Definition

ChEBI: A member of the class of biguanides that is biguanide in which one of the terminal nitrogen atoms is substituted by a 2-phenylethyl group. It was used as an anti-diabetic drug but was later withdrawn from the market due to potential risk of lactic acidos s.

Manufacturing Process

15.76 g of β-phenylethylamine hydrochloride and 8.4 g of dicyandiamide were ground and intimately mixed. The mixture was heated in an oil bath in a 3neck flask fitted with a thermometer and stirrer, and the mixture began to melt at a bath temperature of 125°C and was completely fluid at 130°C. Further heating at 145°C to 150°C initiated an exothermic reaction and the temperature of the fusion mixture (156°C) exceeded the oil bath temperature (150°C) by 6°. Heating was continued for one hour at bath temperature of 148°C to 150°C. The reaction mixture was cooled, dissolved in about 100 cc of methanol and filtered. The methanol filtrate was concentrated under reduced pressure, cooled and the product (β-phenylethylbiguanide hydrochloride) filtered off and recrystallized from 95% isopropanol.

brand name

DBI (Ciba-Geigy);Adibetin;Antipond;Bi-uglucon ud87;D bretard;Daopar;Db comb.;Db retard;De be;Debej;Diaformin;Dibein retard;Dibenide;Dibinyl;Dibolin;Dibophen;Dibun;Diebin retard;Diguabet;Dobeom;Fenguanide;Gluciferne;Glucifrene;Glucopstin;Kataglicina;Ls 6030;Oraleo;Prontoformin;Tolbrtaphen.

Therapeutic Function

Antidiabetic

World Health Organization (WHO)

Phenformin, a biguanide with oral hypoglycaemic activity, was introduced in 1957 for the management of diabetes mellitus. By 1970 its use had been associated with incidences of lactic acidosis and by 1976 clinical studies had conclusively demonstrated that the hazards of phenformin treatment outweighed the benefits. Preparations containing phenformin were withdrawn in several countries and their use restricted in others. Elsewhere, however, proprietary preparations containing this drug may remain available. The related biguanide, buformin, has been also associated with lactic acidosis and has been subjected to similar restrictions as phenformin, whereas there is some evidence that metformin is less liable to induce lactic acidosis. (Reference: (WHODI) WHO Drug Information, 2, 4, 1977)

Safety Profile

Poison by intraperitoneal, subcutaneous, and intravenous routes. Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of NOx.

Enzyme inhibitor

This oral, biguanide-class antidiabetic (FWhydrochloride = 241.72 g/mol; M.P. = 175-178°C; typically supplied as the water-soluble hydrochloride salt), also known as phenethylbiguanide and phenylethylbiguanide, and named systematically as N’-b-phenethylformamidinyliminourea, was withdrawn from the U.S. market in 1977 due to high risk of inducing often fatal lactic acidosis. Target(s): cholesterol biosynthesis; 7-dehydrocholesterol reductase; diamine oxidase; glucose transport; insulysin; pyruvate kinase; and ubiquinol:cytochrome c reductase. Phenformin is an activator of AMP-stimulated protein kinase, and like ther AMPK activators also induce nucleoli re-organization, with attendanty changes in cell proliferation. Among the compounds tested, phenformin and resveratrol had the most pronounced impact on nucleolar organization. 1. McDonald & Dalidowicz Biochemistry

Phenformin Preparation Products And Raw materials

Raw materials

Preparation Products


Phenformin Suppliers

Global( 98)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Accela ChemBio Inc.
(+1)-858-699-3322
(+1)-858-876-1948 info@accelachem.com United States 19969 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23035 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com CHINA 47498 58
career henan chemical co
13203830695 0086-371-86658258
0086-371-86658258 factory@coreychem.com CHINA 29864 58
Hefei TNJ Chemical Industry Co.,Ltd.
0551-65418671
0551-65418697 sales@tnjchem.com CHINA 37441 58
Shaanxi Dideu Medichem Co. Ltd
18192503167 +86-29-89586680
+86-29-88380327 1005@dideu.com CHINA 9938 58
Xi'an ZB Biotech Co.,Ltd
+8618591943808
sales01@xazbbio.com CHINA 1596 58
XI'AN TIANGUANGYUAN BIOTECH CO., LTD.
18802962783
rebecca@tgybio.com CHINA 1217 58
Hebei Crovell Biotech Co Ltd
19930504644 whatsapp +8619930504644
86-0311-66562153 sales4@crovellbio.com CHINA 2885 58

View Lastest Price from Phenformin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-12-01 Phenformin
114-86-3
US $10.50 / KG 1KG 99% 10 ton Hebei Crovell Biotech Co Ltd
2020-07-09 Phenformin
114-86-3
US $3388.00 / KG 1KG 98.0% 1T Shaanxi Dideu Medichem Co. Ltd
2020-02-11 phenformin
114-86-3
US $9.80 / KG 1g >98% 20 tons Career Henan Chemical Co

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