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(S)-5-Hydroxymethyldihydrofuran-2-one

(S)-5-Hydroxymethyldihydrofuran-2-one structure

CAS No.: 32780-06-6

Chemical Name:: (S)-5-Hydroxymethyldihydrofuran-2-one

Synonyms: 5-(Hydroxymethyl)dihydro-2(3H)-furanone;(S)-(+)-γ-Hydroxymethyl-γ(S)-Gamma-Hydroxymethyl-Gamma;(S)-4-HYDROXYMETHYL BUTYROLACTONE;(5S)-5-(hydroxyMethyl)oxolan-2-one;(s)-γ-hydroxymethyl-γ-butyrolactone;(S)-5-Hydroxymethyldihydrofuran-2-on;(S)-(+)-G-HYDROXYMETHYL-G-BUTYROLACTONE;(S)-5-HYDROXYMETHYL-DIHYDRO-FURAN-2-ONE

CBNumber:: CB6702069

Molecular Formula:: C5H8O3

Molecular Weight:: 116.12

MDL Number:: MFCD00066224

MOL File:: 32780-06-6.mol

MSDS File:: SDS

Last updated:2023-06-08 17:06:38

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(S)-5-Hydroxymethyldihydrofuran-2-one Properties

Melting point	72-74 °C
Boiling point	110-115 °C/0.2 mmHg (lit.)
alpha	56 º (c=3 in chloroform)
Density	1.237 g/mL at 25 °C (lit.)
refractive index	n20/D 1.471(lit.)
Flash point	>230 °F
storage temp.	2-8°C
pka	14.12±0.10(Predicted)
form	clear liquid
color	Colorless to Almost colorless
optical activity	[α]20/D +56°, c = 3 in chloroform
BRN	1680284
CAS DataBase Reference	32780-06-6(CAS DataBase Reference)
NIST Chemistry Reference	(S)-(+)-2',3'-dideoxyribonolactone(32780-06-6)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Hazard Codes

Risk Statements

36/37/38

Safety Statements

23-24/25-37/39-26

WGK Germany

HS Code

29322090

NFPA 704

	1
0		0

(S)-5-Hydroxymethyldihydrofuran-2-one price More Price(26)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	348902	(S)-(+)-Dihydro-5-(hydroxymethyl)-2(3H)-furanone 95%	32780-06-6	1g	$226	2023-06-20	Buy
TCI Chemical	H0958	(S)-(+)-γ-Hydroxymethyl-γ-butyrolactone >94.0%(GC)	32780-06-6	1g	$114	2024-03-01	Buy
TCI Chemical	H0958	(S)-(+)-γ-Hydroxymethyl-γ-butyrolactone >94.0%(GC)	32780-06-6	5g	$504	2024-03-01	Buy
TRC	H973063	(S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one	32780-06-6	1g	$65	2021-12-16	Buy
Matrix Scientific	119181	(S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one 95+%	32780-06-6	1g	$72	2021-12-16	Buy

Product number	Packaging	Price	Buy
348902	1g	$226	Buy
H0958	1g	$114	Buy
H0958	5g	$504	Buy
H973063	1g	$65	Buy
119181	1g	$72	Buy

(S)-5-Hydroxymethyldihydrofuran-2-one Chemical Properties,Uses,Production

Chemical Properties

Colorless to light yellow liqui

Uses

(S)-(+)-Dihydro-5-(hydroxymethyl)-2(3H)-furanone can be used as a chiral synthon to synthesize:

Potent nucleoside, acetylcholine, and (+)-muricatacin analogs.
Mevinic acids, which are LDL cholesterol-lowering agents.
Adenine based anti-HIV agent named β-F-ddA.

General Description

Dihydro-5-(hydroxymethyl)-2(3H)-furanone is a chiral building block widely used in the synthesis of many natural products and few biologically significant compounds like anti-HIV dideoxynucleosides. It is also used in the synthesis of optically active ligands.

(S)-5-Hydroxymethyldihydrofuran-2-one synthesis

Synthesis of (S)-5-Hydroxymethyldihydrofuran-2-one from Methanol and D(+)-Ribonic acid gamma-lactone

(S)-5-Hydroxymethyldihydrofuran-2-one Preparation Products And Raw materials

Raw materials

Borane-methyl sulfide complex L-Glutamic acid Sodium nitrite Tetrahydrofuran Benzene

Ethyl acetate Hydrochloric acid Methanol PETROLEUM ETHER Pentanoic acid, 4,5-dihydroxy-, methyl ester, (4S)-

D-threo-Pentonic acid, 2-deoxy-, γ-lactone (5S)-5-(trityloxymethyl)-5H-furan-2-one 2-Oxiranepropanoic acid, methyl ester, (2R)- 2-Oxiranepropanoic acid, methyl ester (S)-(+)-GAMMA-(TRITYLOXYMETHYL)-GAMMA-BUTYROLACTONE

(S)-(-)HYDROXYMETHYL-3(2H)-FURANONE (1S,5R)-6,8-dioxabicyclo[3.2.1]octan-4-one

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Preparation Products

(S)-5-Hydroxymethyldihydrofuran-2-one Suppliers

Global( 157)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15371	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	7836	58
Accela ChemBio Inc.	(+1)-858-699-3322	info@accelachem.com	United States	19965	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	contact@fuxinpharm.com	China	10297	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21149	58
SIMAGCHEM CORP	+86-13806087780	sale@simagchem.com	China	17367	58

Supplier	Advantage
Shanghai Daken Advanced Materials Co.,Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Accela ChemBio Inc.	58
Chongqing Chemdad Co., Ltd	58
Alchem Pharmtech,Inc.	58
Fuxin Pharmaceutical	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
SIMAGCHEM CORP	58

View Lastest Price from (S)-5-Hydroxymethyldihydrofuran-2-one manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-07-06	(S)-5-Hydroxymethyldihydrofuran-2-one 32780-06-6	US $1.00 / KG	1KG	98%	150KG	Career Henan Chemical Co

(S)-5-Hydroxymethyldihydrofuran-2-one
32780-06-6
US $1.00 / KG
98%
Career Henan Chemical Co

(S)-5-Hydroxymethyldihydrofuran-2-one Spectrum

(S)-5-Hydroxymethyldihydrofuran-2-one(32780-06-6)¹HNMR (S)-5-Hydroxymethyldihydrofuran-2-one(32780-06-6)IR

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Trimethylolpropane Gamma Butyrolactone (1S)-(-)-Camphanic acid

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(S)-(+)-gamma-Hydroxymethyl-gamma-butyrolactone,97% (S)-Gamma-Hydroxymethyl-Gamma (S)-(+)-Dihydro-5-(hydroxymethyl)-2(3H)-furanone ,97% (5S)-5-(HYDROXYMETHYL)-3,4,5-TRIHYDROFURAN-2-ONE (5S)-(+)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one (S)-(+)-4,5-Dihydro-5-hydroxymethyl-2(3H)-furanone (S)-(+)-5-Hydroxymethyltetrahydro-2-furanone 5-Oxo-tetrahydro-furan-2-carboxylic acid ethyl ester (5S)-5-(hydroxyMethyl)oxolan-2-one 2(3H)-Furanone,dihydro-5-(hydroxyMethyl)-, (5S)- (S)-(+)-Dihydro-5-(hydroxymethyl)-2(3H)-furanone 95% (S)-(+)-&gamma -Hydroxymethyl-&gamma (S)-(+)-DIHYDRO-5-(HYDROXYMETHYL)-2(3H)-FURANONE (S)-(+)-DIHYDRO-5-(HYDROXYMETHYL)FURANONE (S)-(+)-GAMMA-HYDROXYMETHYL-GAMMA-BUTYROLACTON (S)-(+)-GAMMA-HYDROXYMETHYL-GAMMA-BUTYROLACTONE (S)-GAMMA-HYDROXYMETHYL-GAMMA-BUTYROLACTONE (S)-(+)-G-HYDROXYMETHYL-G-BUTYROLACTONE (S)-(+)-4,5-DIHYDRO-5-HYDROXYMETHYL-2(3H)-FURANONE (S)-4,5-DIHYDRO-5-HYDROXYMETHYL-2(3H)-FURANONE DIHYDRO-5-(HYDROXYMETHYL)-2(3H)-FURANONE (S-) 2(3H)-FURANONE, DIHYDRO-5-(HYDROXYMETHYL)-,(S) (S)-4-HYDROXYMETHYL BUTYROLACTONE (S)-5-HYDROXYMETHYL-2-OXOTETRAHYDROFURAN (S)-5-HYDROXYMETHYL-DIHYDRO-FURAN-2-ONE (S)-(+)-5-HYDROXYMETHYL-GAMMA-BUTYROLACTONE (S)-(+)-5-HYDROXYMETHYLTETRAHYDRO-2-FURANONE (S)-γ-Hydroxymethyl-γ-butyrolactone, (S)-4,5-Dihydro-5-hydroxymethyl-2(3H)-furanone, (S)-5-Hydroxymethyl-2-oxotetrahydrofuran (S)-4,5-Dihydro-5-hydroxymethyl-2(3H)-furanone, (S)-5-Hydroxymethyl-2-oxotetrahydrofuran (S)-(+)-DIHYDRO-5-(HYDROXYMETHYL)-2(3H)- FURANONE, 95% (98% EE/GLC) (S)-GAMMA-HYDROXYMETHYL-GAMMA-BUTYRO- & (s)-γ-hydroxymethyl-γ-butyrolactone (S)-(+)-5-HYDROXYMETHYL-GAMMA-BUTYROLACTONE 98% (5S)-5-(hydroxymethyl)-2-oxo-tetrahydrofuran (S)-5-Hydroxymethyldihydrofuran-2-on (S)-(+)-γ-Hydroxymethyl-γ-butyrolactone> 5-(Hydroxymethyl)dihydro-2(3H)-furanone (5S)-5-(Hydroxymethyl)dihydro-2(3H)-furanone 32780-06-6 Asymmetric Synthesis Chiral Building Blocks Heterocyclic Building Blocks Furans chiral Chiral Reagent