(R)-(+)-2-(4-Hydroxyphenoxy)propionic acid
- CAS No.
- 94050-90-5
- Chemical Name:
- (R)-(+)-2-(4-Hydroxyphenoxy)propionic acid
- Synonyms
- D-HPPA;(R)-2-(4-HYDROXYPHENOXY)PROPIONIC ACID;(R)-(+)-2-(4-Hydroxy;Hydroxy phenyl propionate;Phenyl Acetate Impurity 24;HYDROXYPHENOXYPROPIONIC ACID;(R)-(+)-2-(4-Hydroxyphenoxy);(-)-p-Hydroxyhydratropic acid;(R)-(+)-2-(4-Hydroxyphenoxy)Pr;R-(+)-2-(HYDROXYPHENOXY)PROPIONIC
- CBNumber:
- CB6711601
- Molecular Formula:
- C9H10O4
- Molecular Weight:
- 182.17
- MDL Number:
- MFCD00274088
- MOL File:
- 94050-90-5.mol
- MSDS File:
- SDS
Melting point | 145-148 °C (lit.) |
---|---|
alpha | 58 º (c=1, MeOH) |
Boiling point | 367.5±17.0 °C(Predicted) |
Density | 1.302±0.06 g/cm3(Predicted) |
refractive index | 38 ° (C=0.1, MeOH) |
storage temp. | Inert atmosphere,Room Temperature |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | Solid |
pka | 3.32±0.10(Predicted) |
color | Off-White |
optical activity | [α]20/D +58°, c = 1 in methanol |
InChI | InChI=1S/C9H10O4/c1-6(9(11)12)13-8-4-2-7(10)3-5-8/h2-6,10H,1H3,(H,11,12)/t6-/m1/s1 |
InChIKey | AQIHDXGKQHFBNW-ZCFIWIBFSA-N |
SMILES | C(O)(=O)[C@H](OC1=CC=C(O)C=C1)C |
CAS DataBase Reference | 94050-90-5(CAS DataBase Reference) |
FDA UNII | WSI8A5QG10 |
(R)-(+)-2-(4-Hydroxyphenoxy)propionic acid price More Price(21)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 474533 | (R)-(+)-2-(4-Hydroxyphenoxy)propionic acid 98% | 94050-90-5 | 25g | $40.8 | 2024-03-01 | Buy |
TCI Chemical | H0937 | (R)-(+)-2-(4-Hydroxyphenoxy)propionic Acid >98.0%(GC)(T) | 94050-90-5 | 5g | $24 | 2022-04-27 | Buy |
TRC | H949715 | (R)-(+)-2-(4-Hydroxyphenoxy)propionic acid | 94050-90-5 | 10g | $55 | 2021-12-16 | Buy |
Chem-Impex | 39505 | (R)-(+)-2-(4-Hydroxyphenoxy)propionicacid,≥98%(Assaybytitration,GC) ≥98%(Assaybytitration,GC) | 94050-90-5 | 5G | $25.63 | 2021-12-16 | Buy |
Frontier Specialty Chemicals | JK312017 | (R)-(+)-2-(4-Hydroxyphenoxy)propionic acid 98% | 94050-90-5 | 5g | $28 | 2021-12-16 | Buy |
(R)-(+)-2-(4-Hydroxyphenoxy)propionic acid Chemical Properties,Uses,Production
Chemical Properties
White to off-white powder or crystal
Uses
(R)-(+)-2-(4-Hydroxyphenoxy)propionic Acid is a degradation product of Cyhalofop-butyl (C989385); an aryloxyphenoxypropionate compound that is used as a herbicide to eliminate grass weeds in rice fields. Cyhalofop-butyl works by selectively inhibiting acetyl CoA carboxylase, an enzyme that is important for the metabolism of fatty acids.
Synthesis
(R)-2-(4-hydroxyphenoxy)propionic acid ((R)-HPOPA) is an essential intermediate for the production of chiral aryloxyphenoxypropionic acid-type herbicides such as clod inafop-propargyl, cyhalofop-butyl, fenoxaprop-p-ethyl, metam ifop, quizalofop-p-ethyl, and quizalofop-p-tefuryl. In general, there are three chemical methods for the preparation of (R)-HPOPA: (1) resolution of racemic HPOPA with alkaloids such as quinine, cinchonine, ephedrine, vauquline or chiral agents such as S-(?)-α-phenylethylamine, L-(+)-chloromethane, R-(+)-α-isopropyl-4-chlorobenzylamine and (2) asymmetric synthesis from L-lactic acids or L-alanine. However, these methods are not always useful for industrial applications because of expensive reagents, problems with enantiopurity of product and low yields. Regioselective hydroxylation of (R)-2-phenoxypropionic acid ((R)-POPA) by microbes is a highly feasible method for the production of (R)-HPOPA, which under mild conditions allows complete transformation of substrate into a single stereoisomeric product with a high yield and without byproduct formation[1-2].
References
[1] Hai-Feng Hu . “A rapid throughput assay for screening (R)-2-(4-hydroxyphenoxy)propionic acid producing microbes.” Journal of microbiological methods 158 (2019): Pages 44-51.
[2] Haiyan Zhou. “An efficient route towards R-2-phenoxypropionic acid synthesis for biotransformative production of R-2-(4-hydroxyphenoxy)propionic acid.” Chinese Journal of Chemical Engineering 32 (2021): Pages 315-323.
(R)-(+)-2-(4-Hydroxyphenoxy)propionic acid Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
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shandong exelon biochem co.ld | +86-533-2119995 +8615053330977 | 451614802@QQ.com | China | 30 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12446 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5872 | 58 |
Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | admin@guyunchem.com | China | 616 | 58 |
hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 | sales03@chemcn.cn | China | 973 | 58 |
Hebei Mojin Biotechnology Co.,Ltd | +86-15028179902 | angelia@hbmojin.com | China | 1069 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18628 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21667 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
View Lastest Price from (R)-(+)-2-(4-Hydroxyphenoxy)propionic acid manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-20 | (R)-(+)-2-(4-Hydroxyphenoxy)propionic acid
94050-90-5
|
US $0.00 / KG | 1KG | 99% | 1000mt/year | Jinan Finer Chemical Co., Ltd | ||
2024-09-20 | (R)-(+)-2-(4-Hydroxyphenoxy)propionic acid
94050-90-5
|
US $30.00 / kg | 1kg | 98% | 2000kg | hebei hongtan Biotechnology Co., Ltd | ||
2024-09-19 | (R)-(+)-2-(4-Hydroxyphenoxy)propionic acid
94050-90-5
|
US $5.00-2.00 / KG | 1KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD |
- (R)-(+)-2-(4-Hydroxyphenoxy)propionic acid
94050-90-5
- US $0.00 / KG
- 99%
- Jinan Finer Chemical Co., Ltd
- (R)-(+)-2-(4-Hydroxyphenoxy)propionic acid
94050-90-5
- US $30.00 / kg
- 98%
- hebei hongtan Biotechnology Co., Ltd
- (R)-(+)-2-(4-Hydroxyphenoxy)propionic acid
94050-90-5
- US $5.00-2.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
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