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PYRIDINE-2-CARBOXAMIDE

CAS No.
1452-77-3
Chemical Name:
PYRIDINE-2-CARBOXAMIDE
Synonyms
PICOLINAMIDE;2-PICOLINAMIDE;Picolinoylamide;PicolinaMide 98%;Picolinamide ,98%;2-Picolinamide>alpha-Picolinamide;TIMTEC-BB SBB008128;2-Carbamoylpyridine;Picolinic acid amide
CBNumber:
CB6713827
Molecular Formula:
C6H6N2O
Molecular Weight:
122.12
MDL Number:
MFCD00023483
MOL File:
1452-77-3.mol
MSDS File:
SDS
Last updated:2023-10-13 18:16:27

PYRIDINE-2-CARBOXAMIDE Properties

Melting point 110 °C (dec.)(lit.)
Boiling point 143 °C / 20mmHg
Density 1.2236 (rough estimate)
refractive index 1.5350 (estimate)
storage temp. Inert atmosphere,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
pka pK1: 2.10(+1) (20°C)
form Solid
color White to Off-White
BRN 109617
CAS DataBase Reference 1452-77-3(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII I3550CCL59
EPA Substance Registry System 2-Pyridinecarboxamide (1452-77-3)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-37/39
WGK Germany  3
TSCA  Yes
HS Code  29333990
NFPA 704
0
2 0

PYRIDINE-2-CARBOXAMIDE price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 104051 Picolinamide 98% 1452-77-3 10g $49.8 2024-03-01 Buy
Sigma-Aldrich 104051 Picolinamide 98% 1452-77-3 50g $237 2024-03-01 Buy
TCI Chemical P0414 2-Picolinamide >98.0%(HPLC)(T) 1452-77-3 25g $105 2024-03-01 Buy
Alfa Aesar A15410 Pyridine-2-carboxamide, 98% 1452-77-3 5g $43.65 2024-03-01 Buy
Alfa Aesar A15410 Pyridine-2-carboxamide, 98% 1452-77-3 25g $169.65 2024-03-01 Buy
Product number Packaging Price Buy
104051 10g $49.8 Buy
104051 50g $237 Buy
P0414 25g $105 Buy
A15410 5g $43.65 Buy
A15410 25g $169.65 Buy

PYRIDINE-2-CARBOXAMIDE Chemical Properties,Uses,Production

Chemical Properties

White to off-white solid

Uses

Picolinamide was used as template in preparation of molecular imprinting polymer. Picolinamide was used in a study to evaluate kinetics and mechanism of liberation of picolinamide from chromium(III)-picolinamide complexes in HClO4.

Uses

A nicotinic acid derivative for prevention and treatment of cancer by activating RUNX3 gene.

Definition

ChEBI: A pyridinecarboxamide that is the monocarboxylic acid amide derivative of picolinic acid.

Biological Activity

picolinamide is a poly (adp-ribose) synthetase (parp) inhibitor.parp inhibitors, a group of pharmacological inhibitors of the enzyme poly adp ribose polymerase (parp), are developed for multiple indications, especially for the treatment of cancer.

Biochem/physiol Actions

Picolinamide is potential inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells. Picolinamide acts as bidentate ligand and forms complexes with lanthanide nitrates, thiocyanates and perchlorates.

in vitro

the pathway of oxidation of picolinamide by a gram-negative rod has been elucidated. results showed that under high ph conditions, whole cells could release 2,5-dihydroxypyridine into culture supernatants. moreover, sodium arsenite was able to cause whole cells to accumulate 6-hydroxypicolinate in the culture media. in addition, whole cells were found to oxidize picolinamide, without lag. it was also found that cell-free extracts could convert picolinamide into picolinate, and hydroxylate picolinate into 6-hydroxypicolinate [1].

in vivo

picolinamide was used in a previous study to evaluate the possibility that the inhibition of na+/phosphate cotransport might be associated with the inhibition of nad hydrolyzing enzymes. results showed that the overnight treatment of rats with picolinamide, administered as a single injection (4 mmol/kg), could inhibit na+/phosphate cotransport by isolated renal brush border membrane vesicles. similar to nicotinamide, the inhibition caused by picolinamide occurred in thyroparathyroidectomized rats, was specific for na+/phosphate cotransport. unlike nicotinamide, there was only a small 1.5-fold increase in renal cortical nad content after picolinamide treatment [2].

References

[1] c. g. orpin,m. knight, and w. c. evans. the bacterial oxidation of picolinamide, a photolytic product of diquatbiochem j. 1972 may; 127(5): 819–831.
[2] campbell pi, al-mahrouq ha,abraham mi,kempson sa. specific inhibition of rat renal na+/phosphate cotransport by picolinamide. j pharmacol exp ther.1989 oct;251(1):188-92.

Global( 228)Suppliers
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View Lastest Price from PYRIDINE-2-CARBOXAMIDE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
PYRIDINE-2-CARBOXAMIDE pictures 2023-10-14 PYRIDINE-2-CARBOXAMIDE
1452-77-3
US $0.00 / KG 1KG 99% 50000KG/month Hebei Mojin Biotechnology Co., Ltd
PYRIDINE-2-CARBOXAMIDE pictures 2023-09-06 PYRIDINE-2-CARBOXAMIDE
1452-77-3
US $0.00 / KG 1KG 99% 500000kg Hebei Guanlang Biotechnology Co., Ltd.
PYRIDINE-2-CARBOXAMIDE pictures 2019-07-06 PYRIDINE-2-CARBOXAMIDE
1452-77-3
US $8.80 / KG 1KG 97%-99% 100kg Career Henan Chemical Co
alpha-Picolinic acid amide Picolinic acid amide Picolinoylamide Pyridine-2-carboxylicamide 2-PYRIDINECARBOXAMIDE 2-PICOLINAMIDE PICOLINAMIDE PYRIDINE-2-CARBOXYLIC ACID AMIDE PYRIDINE-2-CARBOXAMIDE TIMTEC-BB SBB008128 Picolinamide ,98% Picolinamide,2-Pyridinecarboxamide PicolinaMide 98% 2-Carbamoylpyridine alpha-Picolinamide Isoniazid Impurity I Nicotinamide EP Impurity C Nicotinamide Impurity 3(Nicotinamide EP Impurity C) 2-Picolinamide> 2-Picolinamide, 98%, for synthesis PYRIDINE-2-CARBOXAMIDE ISO 9001:2015 REACH 2-aminocarbonyl-pyridine 2-Pyridinecarboxamide (9CI, ACI) pyridine-2-carboxamide (picolinamide) Nicotinamide Impurity C Nicotinamide EP Impurity C(Picolinamide) Pyridin-2-carboxamide 1452-77-3 Heterocyclic Building Blocks Pyridines C6 Building Blocks Amines Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Heterocyclic Compounds