Tert-butyl bis(2-chloroethyl)carbamate
- CAS No.
- 118753-70-1
- Chemical Name:
- Tert-butyl bis(2-chloroethyl)carbamate
- Synonyms
- TERT-BUTYL BIS(2-CHLOROETHYL)CARBAMATE;N-Boc-N;N-Boc-N,N-bis(2-chL;N-bis(2-chloroethyl)amine;N-Boc-Bis(2-chloroethyl) amine;N-BOC-N,N-BIS(2-CHLOROETHYL)AMINE;N-BOC-N,N-Bis(2-chloroethyl)amine 95%;N-Boc-N,N-bis(2-chloroethyl)amine ,95%;CarbaMic acid, bis(2-chloroethyl)-, 1,1-;Bis(2-chloroethyl)-tert-butoxycarbonylaMine
- CBNumber:
- CB6715694
- Molecular Formula:
- C9H17Cl2NO2
- Molecular Weight:
- 242.14
- MDL Number:
- MFCD06858679
- MOL File:
- 118753-70-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| N-Boc-N,N-bis(2-chloroethyl)amine | B601873 | 10mg | $45 |
| tert-ButylN,N-bis(2-chloroethyl)carbamate 95% | B3954 | 1g | $15 |
| tert-ButylN,N-bis(2-chloroethyl)carbamate 95% | B3954 | 5g | $20 |
| N-BOC-N,N-Bis(2-chloroethyl)amine 95% | OR315132 | 5g | $52 |
| tert-ButylN,N-bis(2-chloroethyl)carbamate 95% | B3954 | 25g | $60 |
| More product size | |||
| Boiling point | 290.7±33.0 °C(Predicted) |
|---|---|
| Density | 1.149±0.06 g/cm3(Predicted) |
| Flash point | 130 °C |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| pka | -1.73±0.70(Predicted) |
| form | liquid |
| color | Hazy/turbid |
| Specific Gravity | 1.14 |
| InChI | InChI=1S/C9H17Cl2NO2/c1-9(2,3)14-8(13)12(6-4-10)7-5-11/h4-7H2,1-3H3 |
| InChIKey | FQZLNQAUUMSUHT-UHFFFAOYSA-N |
| SMILES | C(OC(C)(C)C)(=O)N(CCCl)CCCl |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2933199090 |
Tert-butyl bis(2-chloroethyl)carbamate price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | B601873 | N-Boc-N,N-bis(2-chloroethyl)amine | 118753-70-1 | 10mg | $45 | 2021-12-16 | Buy |
| Synthonix | B3954 | tert-ButylN,N-bis(2-chloroethyl)carbamate 95% | 118753-70-1 | 1g | $15 | 2021-12-16 | Buy |
| Synthonix | B3954 | tert-ButylN,N-bis(2-chloroethyl)carbamate 95% | 118753-70-1 | 5g | $20 | 2021-12-16 | Buy |
| Apolloscientific | OR315132 | N-BOC-N,N-Bis(2-chloroethyl)amine 95% | 118753-70-1 | 5g | $52 | 2021-12-16 | Buy |
| Synthonix | B3954 | tert-ButylN,N-bis(2-chloroethyl)carbamate 95% | 118753-70-1 | 25g | $60 | 2021-12-16 | Buy |
Tert-butyl bis(2-chloroethyl)carbamate Chemical Properties,Uses,Production
Uses
Tert-butyl bis(2-chloroethyl)carbamate is a derivative of bis(2-chloroethyl)amine, which is used as a medicinal chemistry and organic synthesis intermediate, where the Boc group in the structure is readily removed to obtain the active carboxyl group in the organic synthesis transformation. And bis(2-chloroethyl)amine is an anticancer drug that acts as a DNA alkylating agent. It induces apoptosis in human hepatocellular carcinoma cells. It has been shown to be effective against drug-resistant mutants and is used in the treatment of tuberculosis.
Synthesis
24424-99-5
821-48-7
118753-70-1
In a 500 mL three-necked flask, 100 g of bis(2-chloroethyl)amine hydrochloride (IV) was added and dissolved in 300 mL of dichloromethane, followed by the addition of 113 g of triethylamine, and the slow dropwise addition of 147 g of di-tert-butyl dicarbonate (Boc anhydride) with continuous stirring, and the reaction was carried out for 4-6 hours. After completion of the reaction, 200 mL of purified water was added for liquid-liquid separation, followed by washing the organic phase with 200 mL of saturated sodium chloride solution and drying the organic layer with anhydrous sodium sulfate. After drying, concentration under reduced pressure afforded 133 g of tert-butyl N,N-bis(2-chloroethyl)carbamate (V) in 98% yield.
References
[1] Tetrahedron, 2004, vol. 60, # 22, p. 4875 - 4878
[2] Patent: US2003/187020, 2003, A1
[3] Patent: WO2006/46024, 2006, A1. Location in patent: Page/Page column 146
[4] Patent: WO2007/125321, 2007, A2. Location in patent: Page/Page column 140-141
[5] Patent: US2003/229067, 2003, A1. Location in patent: Page 26
Tert-butyl bis(2-chloroethyl)carbamate Preparation Products And Raw materials
Raw materials
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Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sach biotech Co.,Ltd | +8615888865902 | sales@hzsqchem.com | China | 63 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21600 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29837 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5906 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
View Lastest Price from Tert-butyl bis(2-chloroethyl)carbamate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-06-11 | Tert-butyl bis(2-chloroethyl)carbamate
118753-70-1
|
US $223.00-200.00 / kg | 1kg | 98% | 5mt | Sach biotech Co.,Ltd | |
 |
2019-07-06 | N-Boc-N,N-bis(2-chloroethyl)amine
118753-70-1
|
US $8.00 / kg | 1kg | 99% | 10tons | Career Henan Chemical Co |
-
- Tert-butyl bis(2-chloroethyl)carbamate
118753-70-1
- US $223.00-200.00 / kg
- 98%
- Sach biotech Co.,Ltd
-
- N-Boc-N,N-bis(2-chloroethyl)amine
118753-70-1
- US $8.00 / kg
- 99%
- Career Henan Chemical Co
