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Prednisone

Prednisone
Prednisone structure
CAS No.
53-03-2
Chemical Name:
Prednisone
Synonyms
MOPP;u6020;Cortan;Deltra;Cotone;deltae;U 6020;Wojtab;delta-E;In-Sone
CBNumber:
CB6716222
Molecular Formula:
C21H26O5
Formula Weight:
358.43
MOL File:
53-03-2.mol

Prednisone Properties

Melting point:
236-238 °C(lit.)
alpha 
169 º (c=0.5, dioxane)
Boiling point:
410.86°C (rough estimate)
Density 
1.1121 (rough estimate)
refractive index 
170 ° (C=0.5, Dioxane)
Flash point:
>200℃
storage temp. 
Refrigerator
solubility 
Practically insoluble in water, slightly soluble in ethanol (96 per cent) and in methylene chloride. It shows polymorphism (5.9).
pka
12.36±0.60(Predicted)
Water Solubility 
115mg/L(25 ºC)
Merck 
7722
BRN 
2065301
Stability:
Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference
53-03-2(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
VB0R961HZT
NCI Dictionary of Cancer Terms
MOPP; prednisone
NIST Chemistry Reference
Prednisone(53-03-2)
Proposition 65 List
MOPP (vincristine-prednisone-nitrogen mustard-procarbazine mixture)
EPA Substance Registry System
Prednisone (53-03-2)
SAFETY
  • Risk and Safety Statements
Hazard Codes  Xn
Risk Statements 
Safety Statements  36/37/39-45-26-16

Prednisone price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 20677 Prednisone ≥98% 53-03-2 1g $25 2020-06-24 Buy
Cayman Chemical 20677 Prednisone ≥98% 53-03-2 5g $113 2020-06-24 Buy
Cayman Chemical 20677 Prednisone ≥98% 53-03-2 10g $200 2020-06-24 Buy
Cayman Chemical 20677 Prednisone ≥98% 53-03-2 25g $375 2020-06-24 Buy

Prednisone Chemical Properties,Uses,Production

Chemical Properties

White or almost white, crystalline powder.

Uses

Adrenocortical steroid. Glucocorticoid, antiinflammatory.

Uses

Downregulates TNF-α production and NF-κB expression

Definition

ChEBI: A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead f the oxo group at position 11), which is the active drug and also a steroid.

Indications

Prednisone 2.5 to 7.5 mg, administered at night or dexamethasone 0.25 to 0.75 mg are useful in female patients, with severe acne unresponsive to conventional therapy, who suffer from adrenal gland overproduction of androgens such as congenital adrenal hyperplasia.

brand name

Cortan (Halsey); Delta-Dome (Bayer); Deltasone (Pharmacia & Upjohn); Liquid Pred (Muro); Meticorten (Schering); Orasone (Solvay Pharmaceuticals); Paracort (Parke-Davis).

General Description

Odorless white crystalline powder.

General Description

Prednisone, Δ1-cortisone, 17,21-dihydroxypregna-1,4-diene-3,11,20-trione, has systemic activityvery similar to that of prednisolone, and because of itslower salt-retention activity, it is often preferred over cortisoneor hydrocortisone. Prednisone must be reduced in vivoto prednisolone to provide the active GC.

Air & Water Reactions

Very slightly water soluble .

Hazard

Questionable carcinogen.

Safety Profile

Poison by intraperitoneal and subcutaneous routes. Moderately toxic by intramuscular route. Human systemic effects: sensory change involving peripheral nerves, dermatitis. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. Has been implicated in aplastic anemia.

Purification Methods

Crystallise prednisone from acetone/hexane, then recrystallise it from Me2CO. The monoacetate crystallises from Me2CO/hexane with m 227-233o(dec), [] D +186o (c 1, dioxane), and the diacetate crystallises from 25Me2CO/hexane with m 219-221o(dec), [] D +125o (c 1, CHCl3). [Hertzog et al. Tetrahedron 18 581 1962, Beilstein 8 IV 3531.]

Prednisone Preparation Products And Raw materials

Raw materials

Preparation Products


Prednisone Suppliers

Global( 284)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
PI & PI BIOTECH INC.
18371201331
020-81716319 Sales@pipitech.com CHINA 3050 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21821 58
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22626 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 568 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30045 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23977 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28234 58
Cangzhou Wanyou New Material Technology Co.,Ltd
18631714998
sales@czwytech.com CHINA 914 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6371 58

View Lastest Price from Prednisone manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-07-31 Bicortone
53-03-2
US $1.00 / g 1g 99% 10 tons Cangzhou Wanyou New Material Technology Co.,Ltd
2018-12-17 Prednisone
53-03-2
US $7.00 / kg 1kg 99% 100KG career henan chemical co
2018-03-09 Prednisone
53-03-2
US $10.00 / KG 10G 99%min 100kg/week Hubei XinRunde Chemical Co., Ltd.

Prednisone Spectrum


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