N-Acetylneuraminic Acid Aldolase
- CAS No.
- 9027-60-5
- Chemical Name:
- N-Acetylneuraminic Acid Aldolase
- Synonyms
- C:C&B4;EC 4.1.3.3;Sialate lyase;NANA Aldolase;NEU5AC ALDOLASE;SIALIC ALDOLASE;Sialic acid lyase;Neuraminic aldolase;Neu5Ac Aldolase 001;Neuraminate aldolase
- CBNumber:
- CB6717825
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD00131656
- MOL File:
- Mol file
| storage temp. | -20°C |
|---|---|
| form | powder |
| color | slightly yellow |
| BRN | 2697172 |
| EPA Substance Registry System | Lyase, acetylneuraminate (9027-60-5) |
SAFETY
Risk and Safety Statements
| Hazard Codes | Xi |
|---|---|
| Risk Statements | 36/37/38 |
| Safety Statements | 23-24/25-60-37-26-22 |
| WGK Germany | 3 |
| F | 10 |
N-Acetylneuraminic Acid Aldolase price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A6680 | N-Acetylneuraminic Acid Aldolase from microorganisms lyophilized powder, ≥20?units/mg protein (biuret) | 9027-60-5 | 25units | $606 | 2024-03-01 | Buy |
| Usbiological | 294617 | Sialic acid aldolase | 9027-60-5 | 5g | $396 | 2021-12-16 | Buy |
| Usbiological | 294618 | Sialic acid aldolase | 9027-60-5 | 10g | $432 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | ENZ0000886 | N-ACETYLNEURAMINIC ACID ALDOLASE 95.00% | 9027-60-5 | 5MG | $505.08 | 2021-12-16 | Buy |
| Biosynth Carbosynth | MS11080 | Sialic acid aldolase - crystalline | 9027-60-5 | 50g | $525 | 2021-12-16 | Buy |
N-Acetylneuraminic Acid Aldolase Chemical Properties,Uses,Production
Uses
This enzyme is useful for enzymatic determination of N-acetylneuraminic acid and sialic acid when
coupled with the related enzymes in clinical analysis.
For industrial use, this enzyme is useful for enzymatic synthesis of sialic acid.
Uses
Sialic acid aldolase can be used to synthesize unnatural sugars of C(6) to C(10) for the design of antagonists and inhibitors of glycoenzymes.
General Description
Sialic acid aldolases, or N-acetylneuraminate lyases, catalyze the reversible aldol cleavage of N-acetylneuraminic acid to form pyruvate and N-acetyl-D-mannosamine. In nature, N-acetylneuraminate lyase mainly occurs in pathogens.
Purification Methods
Purify the aldolase by extraction with H2O, protamine precipitation, (NH4)2SO4 fractionation, Me2CO precipitation, acid treatment at pH 5.7 and precipitation at pH 4.5. The equilibrium constant for pyruvate + n-acetyl-D-mannosamine N-acetylneuraminidate at 37o is 0.64. The Km for N-acetylneuraminic acid is 3.9mM in phosphate at pH 7.2 and 37o. [Comb & Roseman Methods Enzymol 5 391 1962.] The enzyme from hog kidney (cortex) has been purified 1700-fold by extraction with H2O, protamine sulfate precipitation, (NH4)2SO4 fractionation, heating between 60-80o, a second (NH4)2SO4 fractionation and starch gel electrophoresis. The Km for N-acetylneuraminic acid is 1.5mM. [Brunetti et al. J Biol Chem 237 2447 1962.]
N-Acetylneuraminic Acid Aldolase Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Creative Enzymes | 1-516-855-7709 | info@creative-enzymes.com | United States | 8748 | 58 |
| Hubei Xindesheng Material Technology Co., Ltd. | +8618971041571 | vickyzhao@whdschem.com | China | 174 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29271 | 58 |
| NewCan Biotech Limited | +86-0571-86912261 +8613735419629 | sales@newcanbio.com | China | 10027 | 58 |
| ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 | admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com | China | 20000 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
View Lastest Price from N-Acetylneuraminic Acid Aldolase manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-07-01 | N-Acetylneuraminic Acid Aldolase
9027-60-5
|
US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited |
-
- N-Acetylneuraminic Acid Aldolase
9027-60-5
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
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