HISPIDULIN
- CAS No.
- 1447-88-7
- Chemical Name:
- HISPIDULIN
- Synonyms
- Dinatin;HISPIDULIN;Hispedulin;Methoxyapigenin;Hispidulin, >99%;6-Methoxyapigenin;Hispidulin(Dinatin);6-Methylscutellarein;SCUTELLAREIN 6-METHYL ETHER;4',5,7-Trihydroxy-6-methoxyflavone
- CBNumber:
- CB6723941
- Molecular Formula:
- C16H12O6
- Molecular Weight:
- 300.26
- MDL Number:
- MFCD00143504
- MOL File:
- 1447-88-7.mol
- MSDS File:
- SDS
Melting point | 291-292 °C |
---|---|
Boiling point | 601.5±55.0 °C(Predicted) |
Density | 1.512±0.06 g/cm3(Predicted) |
storage temp. | -20°C |
solubility | DMSO: soluble20mg/mL, clear |
pka | 6.51±0.40(Predicted) |
form | powder |
color | white to beige |
FDA UNII | N7F61604C2 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H302 | |||||||||
Precautionary statements | P280-P305+P351+P338 | |||||||||
Hazard Codes | Xn | |||||||||
Risk Statements | 22 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | DJ2996000 | |||||||||
NFPA 704 |
|
HISPIDULIN price More Price(36)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML0582 | Hispidulin ≥98% (HPLC) | 1447-88-7 | 5mg | $140 | 2024-03-01 | Buy |
Sigma-Aldrich | SML0582 | Hispidulin ≥98% (HPLC) | 1447-88-7 | 25mg | $543 | 2024-03-01 | Buy |
Cayman Chemical | 26383 | Hispidulin | 1447-88-7 | 5mg | $86 | 2024-03-01 | Buy |
Cayman Chemical | 26383 | Hispidulin | 1447-88-7 | 25mg | $305 | 2024-03-01 | Buy |
Cayman Chemical | 26383 | Hispidulin | 1447-88-7 | 1mg | $32 | 2024-03-01 | Buy |
HISPIDULIN Chemical Properties,Uses,Production
Uses
Hispidulin has been used as a calibration standard:
- in high-performance liquid chromatography (HPLC) for quantification of Clerodendrum petasites flavonoids
- in liquid chromatography/electrospray ionization mass spectrometry (LC/ESI-MS) analysis
- in reverse-phase high-performance liquid chromatography with a diode-array detector (HPLC-DAD) and high-performance thin-layer chromatography (HPTLC)
Definition
ChEBI: A monomethoxyflavone that is scutellarein methylated at position 6.
General Description
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Biological Activity
Partial positive allosteric modulator at the benzodiazepine receptor (IC 50 = 1.3 μ M for inhibition of flumazenil binding); natural sage flavone. Stimulates GABA-induced chloride currents in Xenopus oocytes expressing α 1 α 2-, α 3-, α 5- or α 6- β 2 γ 2S GABA A receptors. Brain penetrant; oral administration reduces seizures in a gerbil model of epilepsy. Also has antifungal, antiproliferative, antioxidant and antithrombotic properties.
Biochem/physiol Actions
Hispidulin is a bioactive flavonoid with a variety of effects including antiproliferative, antifungal, anti-inflammatory, antioxidative and antiepileptic activity. Like EGCG, hispidulin appears to activate AMPK and inhibit the PI3K/Akt/mTOR pathway. The antiepileptic activity may be due to additional activity as a benzodiazepine (BZD) receptor ligand.
HISPIDULIN Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
Chengdu Greenpure Biopharma CO.,Ltd | 18283602253; +8618283602253 | jancyzheng@gcgreenpure.com | China | 953 | 58 |
Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3772 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 3000 | 58 |
Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49392 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29823 | 58 |
Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
View Lastest Price from HISPIDULIN manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2023-02-24 | Hispidulin
1447-88-7
|
US $0.00 / mg | 20mg | ≥98%(HPLC) | 100 g | Shanghai Standard Technology Co., Ltd. | ||
2019-12-26 | HISPIDULIN
1447-88-7
|
US $6.60 / KG | 500g | 98% | 1kg, 50kg, 100kg | Career Henan Chemical Co |
- Hispidulin
1447-88-7
- US $0.00 / mg
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
- HISPIDULIN
1447-88-7
- US $6.60 / KG
- 98%
- Career Henan Chemical Co
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