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(R)-CPP

(R)-CPP structure

CAS No.: 126453-07-4

Chemical Name:: (R)-CPP

Synonyms: D-CPP;(R)-CCP;(R)-CPP;CPP (R)-;(R)CPP,(R) CPP;rac-(S*)-2-(2,4-Dichlorophenoxy)propanoic acid;rac-(2R*)-2-(2,4-Dichlorophenoxy)propionic acid;rac-(2R*)-2-(2,4-Dichlorophenoxy)propanoic acid;(R)-4-(3-phosphonopropyl)piperazine-2-carboxylic acid;[3-[(2R)-2-Carboxypiperazin-4-yl]propyl]phosphonic acid

CBNumber:: CB6725314

Molecular Formula:: C8H17N2O5P

Molecular Weight:: 252.2

MDL Number:: MFCD00153786

MOL File:: 126453-07-4.mol

Last updated:2023-06-30 15:45:59

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(R)-CPP Properties

Boiling point	546.7±60.0 °C(Predicted)
Density	1.408±0.06 g/cm3(Predicted)
storage temp.	Desiccate at RT
solubility	Water: 100mM
form	White crystalline powder.
pka	1.89±0.20(Predicted)
Water Solubility	Soluble to 100 mM in water
FDA UNII	A3QV2VT7SN

(R)-CPP price More Price(9)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	21569	(R)-CPP	126453-07-4	1mg	$37	2024-03-01	Buy
Cayman Chemical	21569	(R)-CPP	126453-07-4	5mg	$169	2024-03-01	Buy
Cayman Chemical	21569	(R)-CPP	126453-07-4	10mg	$319	2024-03-01	Buy
Cayman Chemical	21569	(R)-CPP	126453-07-4	25mg	$704	2024-03-01	Buy
Tocris	0247	(R)-CPP	126453-07-4	50	$1574	2021-12-16	Buy

Product number	Packaging	Price	Buy
21569	1mg	$37	Buy
21569	5mg	$169	Buy
21569	10mg	$319	Buy
21569	25mg	$704	Buy
0247	50	$1574	Buy

(R)-CPP Chemical Properties,Uses,Production

Description

(R)-CPP is an NMDA receptor antagonist (K_i = 0.14 μM). It binds to NMDA receptors containing GluN2A, GluN2B, GluN2C, and GluN2D subunits with K_i values of 0.04, 0.3, 0.6, and 2 μM, respectively. It inhibits depolarization induced by NMDA in isolated hemisected frog spinal cord (pA₂ = 6.56) and NMDA-induced sodium efflux from rat brain slices (pA₂ = 6.2). (R)-CPP inhibits the clonic phase of sound-induced seizures in DBA/2 mice (ED₅₀ = 65.8 μmol/kg) and the myoclonic phase of stroboscopic-induced seizures in P. papio photosensitive baboons (ED₅₀ = 127 μmol/kg).

Uses

(R)-CPP is a piperazine derivative demonstrating highly potent NMDA receptor antagonism.

Biological Activity

Highly potent NMDA antagonist; more active isomer. Shows some selectivity for NR2A-containing receptors (K i values are 0.041, 0.27, 0.63 and 1.99 μ M for inhibition of NR2A-, NR2B-, NR2C- and NR2D-containing recombinant NMDA receptors respectively).

storage

Room temperature (desiccate)

(R)-CPP synthesis

Synthesis of (R)-CPP from 117414-78-5

(R)-CPP Preparation Products And Raw materials

Raw materials

117414-78-5 D-4-[(2E)-3-PHOSPHONO-2-PROPENYL]-2-PIPERAZINECARBOXYLIC ACID

Preparation Products

(R)-CPP Suppliers

Global( 61)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
Ascent Scientific	4401179829988	customerservice@ascentscientific.co.uk	United Kingdom	279	60
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	14059	65
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8449	60
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9709	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
Nantong HI-FUTURE Biology Co., Ltd.	58
J & K SCIENTIFIC LTD.	76
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Ascent Scientific	60
BOC Sciences	65
EMMX Biotechnology LLC	60
Shanghai EFE Biological Technology Co., Ltd.	58

126453-07-4((R)-CPP)Related Search:

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D-2,3-Diaminopropionic acid 3-Aminopropylphosphonic acid 3-(N,N-Diethylamino)-L-alanine (R)-CPP 4-CPP

4-METHYLPIPERAZINE-2-CARBOXYLIC ACID 2-Piperazinecarboxaldehyde Aminoacylproline Carboxypeptidase, CPP, Penicillocarboxypeptidase S-1, Proline Carboxypeptidase,CPP【NMDA receptor antagonist】 CHLORINATEDPOLYPROPYLENE(CPP) (R)-2-(2,4-Dichlorophenoxy)propanoic acid

azaleucine [CPP1-7, NPY19-23, Ala31, Aib32, Gln34]-Pancreatic polypeptide (+/-)-3-(2-CARBOXYPIPERAZIN-4-YL)-PROPYL-1-PHOSPHONIC ACID

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(R)-CPP (R)-CCP R(-)-3-(2-CARBOXYPIPERAZIN-4-YL)-PROPYL-1-PHOSPHONIC ACID D-CPP 3-((R)-2-CARBOXYLPIPERAZIN-4-YL)-PROPYL-1-PHOSPHONIC ACID 3-((R)-2-CARBOXYPIPERAZIN-4-YL)-PROPYL-1-PHOSPHONIC ACID 3-((R)-Carboxylpiperazin-4-yl)-propyl-1-phosphonic acid rac-(2R*)-2-(2,4-Dichlorophenoxy)propanoic acid rac-(2R*)-2-(2,4-Dichlorophenoxy)propionic acid rac-(S*)-2-(2,4-Dichlorophenoxy)propanoic acid [3-[(2R)-2-Carboxypiperazin-4-yl]propyl]phosphonic acid 3-[(2R)-2-Carboxypiperazine-4-yl]propane-1-ylphosphonic acid CPP (R)- 2-Piperazinecarboxylic acid, 4-(3-phosphonopropyl)-, (2R)- (R)-4-(3-phosphonopropyl)piperazine-2-carboxylic acid (R)CPP,(R) CPP 126453-07-4 C8H17N2O5P Glutamate Glutamate receptor