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4-Bromotoluene

CAS No.
106-38-7
Chemical Name:
4-Bromotoluene
Synonyms
1-BROMO-4-METHYLBENZENE;P-BROMOTOLUENE;PARA BROMO TOLUENE;1-Brom-4-methylbenzol;uene;ai328596;4-BromotoL;4-Bromtoluol;p-Tolybromide;p-bromo-toluen
CBNumber:
CB6731117
Molecular Formula:
C7H7Br
Molecular Weight:
171.03
MDL Number:
MFCD00000109
MOL File:
106-38-7.mol
MSDS File:
SDS
Modify Date:
2022-08-15 17:38:51

4-Bromotoluene Properties

Melting point 26-29 °C(lit.)
Boiling point 184 °C(lit.)
Density 1.39 g/mL at 25 °C(lit.)
refractive index 1.549
Flash point 185 °F
storage temp. Store below +30°C.
solubility 0.11g/l insoluble
form Crystalline Low Melting Mass
Specific Gravity 1.390
color White
Water Solubility <0.1 g/100 mL at 24 ºC
Merck 14,1439
BRN 1903636
CAS DataBase Reference 106-38-7(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 9E349GQ7EU
NIST Chemistry Reference Benzene, 1-bromo-4-methyl-(106-38-7)
EPA Substance Registry System p-Bromotoluene (106-38-7)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07,GHS09
Signal word  Warning
Hazard statements  H332-H411
Precautionary statements  P261-P271-P273-P304+P340+P312-P391-P501
Hazard Codes  Xn,N,T
Risk Statements  22-38-51/53-36/37/38
Safety Statements  28-61-37/39-26
RIDADR  UN 3077 9/PG 3
WGK Germany  3
RTECS  XS7965600
TSCA  Yes
HazardClass  9
PackingGroup  III
HS Code  29036990
NFPA 704
2
2 0

4-Bromotoluene price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich B82200 4-Bromotoluene 98% 106-38-7 5g $31.9 2022-05-15 Buy
Sigma-Aldrich B82200 4-Bromotoluene 98% 106-38-7 100g $48 2022-05-15 Buy
TCI Chemical B0661 4-Bromotoluene >99.0%(GC) 106-38-7 25g $23 2022-04-27 Buy
TCI Chemical B0661 4-Bromotoluene >99.0%(GC) 106-38-7 100g $54 2022-04-27 Buy
Alfa Aesar A15843 4-Bromotoluene, 98% 106-38-7 25g $22.8 2021-12-16 Buy
Product number Packaging Price Buy
B82200 5g $31.9 Buy
B82200 100g $48 Buy
B0661 25g $23 Buy
B0661 100g $54 Buy
A15843 25g $22.8 Buy

4-Bromotoluene Chemical Properties,Uses,Production

Description

4-Bromotoluene is a p-substituted aryl bromide. As a toluene derivative, it is used as a solvent and starting material for organic synthesis and is found in paints, paint thinners, glues, and other products. 4-Bromotoluene was used in the synthesis of ketones by Cu/Pd-catalyzed decarboxylative cross-coupling reaction. It is also used in manufacturing pharmaceuticals (especially for antihypertensive like losartan, Irbesartan), pesticides and other organic compounds1-3.

References

  1. https://www.sigmaaldrich.com/catalog/search?term=4-Bromotoluene&interface=All&N=0&mode=match%20partialmax&lang=en&region=US&focus=product
  2. https://bbzfrankie.wordpress.com/2013/11/21/application-of-4-bromotoluene/
  3. https://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+6015

Chemical Properties

white crystalline low melting mass, soluble in ethanol, ether and benzene, insoluble in water. toxic, harmful if swallowed, irritating to eyes, respiratory system and skin. 4-bromotoluene is a raw material of organic synthesis, which can be used as the manufacture of p-bromobenzyl, p-bromodibromobenzyl and p-bromobenzaldehyde, etc.

Uses

4-Bromotoluene was used in the synthesis of ketones by Cu/Pd-catalyzed decarboxylative cross-coupling reaction. 4-Bromotoluene undergoes Heck reaction with styrene in the presence of in situ generated palladium complexes of phosphine-functionalized N-heterocyclic carbene ligands.

Preparation

4-Bromotoluene is prepared by diazotization and replacement of p-toluidine. First, add aqueous sulfuric acid solution to crushed p-toluidine while hot, cool to 5°C, and slowly add aqueous sodium nitrite solution until the starch potassium iodide test paper turns blue. Then add a small amount of urea to destroy the excess of sodium nitrite. Then add the synthesized cuprous bromide to hydrobromic acid, heat it to boiling, then slowly add the above diazo salt and distill it until no oil-like substance comes out. Wash, dry, filter, distill at atmospheric pressure and collect 183-185℃ fraction to obtain 4-Bromotoluene.

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 1, p. 136, 1941
Tetrahedron, 64, p. 4999, 2008 DOI: 10.1016/j.tet.2008.03.085

General Description

Crystals, clear pale yellow liquid.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

4-Bromotoluene is incompatible with strong oxidizing agents.

Fire Hazard

4-Bromotoluene is combustible.

Safety Profile

Moderately toxic by inhalation and intraperitoneal routes. When heated to decomposition it emits toxic vapors of Br-.

Purification Methods

Crystallise it from EtOH [Taylor & Stewart J Am Chem Soc 108 6977 1986]. [Beilstein 5 IV 827.]

Global( 403)Suppliers
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Springchem New Material Technology Co.,Limited
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86-13657291602 linda@hubeijusheng.com CHINA 23034 58

View Lastest Price from 4-Bromotoluene manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2022-07-11 4-Bromotoluene
106-38-7
US $40.00-20.00 / kg 1kg 99 20 BTC pharm India
2021-11-27 4-Bromotoluene
106-38-7
US $10.00 / PCS 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.
2021-08-04 4-Bromotoluene
106-38-7
US $10.00 / KG 100KG 99% 100 mt Hebei Guanlang Biotechnology Co., Ltd.
  • 4-Bromotoluene
    106-38-7
  • US $10.00 / PCS
  • 99%
  • Hebei Guanlang Biotechnology Co., Ltd.
  • 4-Bromotoluene
    106-38-7
  • US $10.00 / KG
  • 99%
  • Hebei Guanlang Biotechnology Co., Ltd.
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