ChemicalBook >> CAS DataBase List >>14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE
14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE
- CAS No.
- 42895-58-9
- Chemical Name:
- 14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE
- Synonyms
- AP 10;14-dehydro Andrographolide;Andrographolide Impurity 1;14-deoxy11,12 deoxyandrographolide;14-Deoxy-11,12-didehydroandrographol;14-Deoxy-11,14-didehydroandrographolide;11,12-Didehydro-14-deoxyandrographolide;14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE;Deoxy-11,12-Didehydroandrographolide, 14-;14 - deoxy11,12-12 dehydroandrographolide
- CBNumber:
- CB6735337
- Molecular Formula:
- C20H28O4
- Molecular Weight:
- 332.43
- MDL Number:
- MFCD07778081
- MOL File:
- 42895-58-9.mol
Last updated:2023-05-21 10:59:17
| Melting point | 204-205℃ |
|---|---|
| Boiling point | 519.6±50.0 °C(Predicted) |
| Density | 1.17 |
| storage temp. | Store at -20°C |
| solubility | DMF: 10 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 2 mg/ml |
| pka | 14.80±0.70(Predicted) |
| FDA UNII | 5S0X4YZJ0E |
14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHL89631 | 14-Deoxy-11,12-didehydroandrographolide phyproof? Reference Substance | 42895-58-9 | 10MG | $574 | 2024-03-01 | Buy |
| Sigma-Aldrich | 55549 | 14-Deoxy-11,12-didehydroandrographolide analytical standard | 42895-58-9 | 5mg | $426 | 2024-03-01 | Buy |
| Cayman Chemical | 11670 | 14-deoxy-11,12-didehydro Andrographolide ≥98% | 42895-58-9 | 500μg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 11670 | 14-deoxy-11,12-didehydro Andrographolide ≥98% | 42895-58-9 | 1mg | $87 | 2024-03-01 | Buy |
| Cayman Chemical | 11670 | 14-deoxy-11,12-didehydro Andrographolide ≥98% | 42895-58-9 | 5mg | $263 | 2024-03-01 | Buy |
14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE Chemical Properties,Uses,Production
Description
14-deoxy-11,12-didehydro Andrographolide is an analog of the natural diterpenoid andrographolide that can be isolated from A. paniculata. It retains the anti-inflammatory, antiallergenic, immuno-stimulatory, antiviral, antioxidant, hepatoprotective, and cardiovascular activities of andrographolide without producing cytotoxicity in KB cells (ED50 >20 μg/ml) that can occur with andrographolide 6.5 μg/ml.
Uses
14-Deoxy-11,12-didehydroandrographolide is the derivative of Andrographolide(A637475) is a labdane diterpenoid (2). Andrographolide is the main bioactive component isolated from the medicinal plant Andrographis paniculata (2). Andrographolide showed significant antihepatotoxic action in P. berghei K173-induced hepatic damage in M. natalensis(1). Andrographolide inhibits tumor necrosis factor-α (TNF-α)-induced intercellular adhesion mol.-1 (ICAM-1) expression and adhesion of HL-60 cells onto human umbilical vein endothelial cells (HUVEC), which are associated with inflammatory diseases (2). These findings suggest that Andrographolide may have potential as a cardiovascular-protective agent.
Definition
ChEBI: 14-Deoxy-11,12-didehydroandrographolide is a diterpene lactone. It has a role as a metabolite.
14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 113)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 | info@konochemical.com | China | 2995 | 58 |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 3000 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 15319487004 | 1015@dideu.com | China | 2263 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10326 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29474 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19994 | 58 |
View Lastest Price from 14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-22 | 14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE USP/EP/BP
42895-58-9
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited | |
 |
2020-05-03 | 14-Deoxy-11,12-didehydroandrographolide
42895-58-9
|
US $0.00-0.00 / KG | 1KG | 99.0% | 800 tons | Shaanxi Dideu Medichem Co. Ltd | |
 |
2020-02-18 | 14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE
42895-58-9
|
US $8.00 / KG | 1KG | ＞98% HPLC | 20 tons | Career Henan Chemical Co |
-
- 14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE USP/EP/BP
42895-58-9
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- 14-Deoxy-11,12-didehydroandrographolide
42895-58-9
- US $0.00-0.00 / KG
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
-
- 14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE
42895-58-9
- US $8.00 / KG
- ＞98% HPLC
- Career Henan Chemical Co
42895-58-9(14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE)Related Search:
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14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE
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11,12-Didehydro-14-deoxyandrographolide
14-Deoxy-11,14-didehydroandrographolide
AP 10
Deoxy-11,12-Didehydroandrographolide, 14-
3-[(E)-2-[(1R,4aβ)-2-Methylene-5α-(hydroxymethyl)-5,8aα-dimethyl-6α-hydroxydecalin-1α-yl]ethenyl]-2,5-dihydrofuran-2-one
3-[(E)-2-[(1R,4aβ)-2-Methylene-5α-(hydroxymethyl)-6α-hydroxy-5,8aα-dimethyldecahydronaphthalene-1α-yl]ethenyl]-2,5-dihydrofuran-2-one
3-[(E)-2-[(1R,4aβ)-Decahydro-6α-hydroxy-5α-(hydroxymethyl)-5,8aα-dimethyl-2-methylenenaphthalen-1-yl]vinyl]furan-2(5H)-one
14-Deoxy-11,12-didehydroandrographol
14-Deoxy-11,12-didehydroandrographolide16,15-olide
3,19-Dihydroxylabda-8(17),11,13-trien-16,15-olide
3-((E)-2-((1R,4aS,5R,6R,8aR)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydronaphthalen-1-yl)vinyl)furan-2(5H)-one
14-Deoxy-11,12-didehydroandrographolide?, >98%
2(5H)-Furanone, 3-[(1E)-2-[(1R,4aS,5R,6R,8aR)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethenyl]-
14-dehydro Andrographolide
14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE USP/EP/BP
Andrographolide Impurity 1
4-[(E)-2-[(1R,4aS,5R,6R,8aR)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethenyl]-2H-furan-5-one
14-deoxy11,12 deoxyandrographolide
14 - deoxy11,12-12 dehydroandrographolide
42895-58-9