2-Thiopheneethanol
- CAS No.
- 5402-55-1
- Chemical Name:
- 2-Thiopheneethanol
- Synonyms
- THIOPHENE-2-ETHANOL;2-(thiophen-2-yl)ethan-1-ol;Thiopheneethanol;2-THIOPHENETHANOL;2-(2-THIENYL)ETHANOL;2-THIENYLETHANOL;2-THIOPHENEETHANOL;2- thiophenealcohol;2-Thiophenylethanol;THIOPHENE-2-ETHYANOL
- CBNumber:
- CB6735579
- Molecular Formula:
- C6H8OS
- Molecular Weight:
- 128.19
- MDL Number:
- MFCD00005462
- MOL File:
- 5402-55-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 108-109 °C/13 mmHg (lit.) |
|---|---|
| Density | 1.153 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 214 °F |
| storage temp. | Store below +30°C. |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| form | Liquid |
| pka | 14.77±0.10(Predicted) |
| color | Clear light yellow to gray-green or brownish |
| Water Solubility | slightly soluble |
| BRN | 106985 |
| InChI | 1S/C6H8OS/c7-4-3-6-2-1-5-8-6/h1-2,5,7H,3-4H2 |
| InChIKey | VMJOFTHFJMLIKL-UHFFFAOYSA-N |
| SMILES | OCCc1cccs1 |
| LogP | 1.040 (est) |
| CAS DataBase Reference | 5402-55-1(CAS DataBase Reference) |
| FDA UNII | 332ZDU4HDC |
| NIST Chemistry Reference | 2-Thiopheneethanol(5402-55-1) |
| EPA Substance Registry System | 2-Thiopheneethanol (5402-55-1) |
| UNSPSC Code | 12352104 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P271-P280 | |||||||||
| PPE | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 23-24/25-36-26 | |||||||||
| RIDADR | UN 3334 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 13 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29349990 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
2-Thiopheneethanol price More Price(69)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T27855 | 2-Thiopheneethanol 98% | 5402-55-1 | 5g | $45.3 | 2026-04-30 | Buy |
| Sigma-Aldrich | T27855 | 2-Thiopheneethanol 98% | 5402-55-1 | 25g | $186 | 2026-04-30 | Buy |
| Sigma-Aldrich | 8.18682 | Thiophene-2-ethanol for synthesis | 5402-55-1 | 25mL | $130 | 2026-04-30 | Buy |
| TCI Chemical | T1021 | 2-Thiopheneethanol >98.0%(GC) | 5402-55-1 | 25mL | $39 | 2026-04-30 | Buy |
| TRC | TRC-T368150-1G | 2-Thiopheneethanol | 5402-55-1 | 1g | $59 | 2026-06-03 | Buy |
2-Thiopheneethanol Chemical Properties, Uses, Production
Chemical Properties
clear colorless to slightly brown liquid
Uses
2-Thiopheneethanol, is used as the antithrombotics thiophene chlorine match piperidine intermediates. It is also used as a ticlopidine Intermediate.
Uses
2-Thiopheneethanol is a thiophene derivative used in the preparation of oligothiophene isothiocyanates as fluorescent markers for biopolymers. 2-Thiopheneethanol is also used in the preparation of oth er biologically active compounds such as the analgesic Sulfentanyl and the antithrombotic Clopidogrel Hydrogen Sulfate (C587250).
Definition
ChEBI: 2-(2-Thienyl)ethanol is a heteroarene.
Synthesis Reference(s)
Journal of the American Chemical Society, 64, p. 477, 1942 DOI: 10.1021/ja01255a001
The Journal of Organic Chemistry, 59, p. 4323, 1994 DOI: 10.1021/jo00094a056
Synthesis
1918-77-0
5402-55-1
2.3. Biotransformation experiments: liquid culture inoculum was prepared by pre-culturing the fungal strains in Petri dishes containing malt extract solid medium (MEA: glucose 20 g/L, malt extract 20 g/L, agar 20 g/L, peptone 2 g/L). The fungus was inoculated as a conidial suspension (1 × 10^6 conidia/mL) in a 50 mL conical flask containing 40 mL of malt extract liquid medium. The conical flasks were placed in a constant temperature shaker at 25°C and incubated with oscillation at 110 rpm. After 2 days of preincubation, a DMSO solution with 500 mM substrate was added to give a starting substrate concentration (c0) of 1-5 mM. Three biological replicates were set up for each substrate. After addition of substrate, the experiment continued for 3 days, during which time 1 mL was sampled at predetermined time intervals (typically 24, 48, and 72 h.) After each sampling, the sample was extracted with 500 μL of ethyl acetate (EtOAc), and the organic phase was dried over anhydrous Na2SO4 and analyzed by GC/MS. In some cases (see Section 2.4), the reduction products were separated. Before each set of biotransformation experiments, initial biomass and pH were determined. At the end of the experiment, these parameters were evaluated again. The liquid medium was separated from the biomass by filtration for pH measurements; mycelium was dried at 60°C for 24 h and the dry weight of the biomass was determined. The yield of the product 2-(thiophen-2-yl)ethanol was 72% (3.7 mg) and the yield of the by-product methyl 2-(thiophen-2-yl)acetate was 96% (24.6 mg).1H NMR (400 MHz, CDCl3, TMS): δ = 7.20 (m, 1H, heteroaromatic hydrogens), 6.99 (m, 1H, heteroarylhydrogen), 6.90 (m, 1H, heteroaromatic hydrogen), 3.85 (t, 2H, J=6.2 Hz, CH2OH), 3.02 (t, 2H, J=6.2 Hz, CH2CH2OH). 13C NMR (100 MHz, CDCl3, TMS): δ=140.5, 127.0, 125.8, 124.0, 63.4, 33.3. GC/MS: tR= 9.47 min, m/z 128 (M+, 30%), 110 (5%), 97 (100%).
References
[1] Journal of Medicinal Chemistry, 1998, vol. 41, # 3, p. 346 - 357
[2] Chemical Communications (Cambridge, United Kingdom), 2012, vol. 48, # 85, p. 10514 - 10516,3
[3] European Journal of Organic Chemistry, 2011, # 17, p. 3178 - 3183
[4] Journal of Molecular Catalysis B: Enzymatic, 2015, vol. 116, p. 83 - 88
[5] Patent: US2010/16365, 2010, A1. Location in patent: Page/Page column 26
2-Thiopheneethanol Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu Ai Keda Chemical Technology Co., Ltd. | 4008-755-333 18080918076 | 800078821@qq.com | China | 9706 | 55 |
| Weifang Siyuan Chemical Co., Ltd. | 0536-8888106 17663601818 | 2354379876@qq.com | China | 244 | 58 |
| Changzhou Kafule Environmental Protection Materials Co., Ltd | 18939353630 | 1370806610@qq.com | China | 272 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | 021-50182298 021-50180596 | sales@boylechem.com | China | 2202 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| future industrial shanghai co., ltd | 400-0066400 13621662912 | sales@jonln.com | China | 1989 | 65 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
View Latest Price from 2-Thiopheneethanol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-10-12 | 2-Thiopheneethanol
5402-55-1
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2026-10-12 | 2-Thiopheneethanol
5402-55-1
|
1g | More Than 99% | 100kg/Month | BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | ||
 |
2026-10-09 | 2-Thiopheneethanol
5402-55-1
|
1KG | 99% | 1000kgs | WUHAN FORTUNA CHEMICAL CO., LTD |
-
- 2-Thiopheneethanol
5402-55-1
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- 2-Thiopheneethanol
5402-55-1
- $0.00
- More Than 99%
- BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
-
- 2-Thiopheneethanol
5402-55-1
- $0.00
- 99%
- WUHAN FORTUNA CHEMICAL CO., LTD
