Tetrahydrouridine
- CAS No.
- 18771-50-1
- Chemical Name:
- Tetrahydrouridine
- Synonyms
- nsc-112907;nsc-112907-d;DFMA | RMI 71897;TETRAHYDROURIDINE;3,4,5,6-tetrahydrouridine;Tetrahydrouridine dihydrate;Uridine, 3,4,5,6-tetrahydro-;3,4,5,6-Tetrahydrouridine (>3,4,5,6-Tetrahydrouridine (>80%);Tetrahydrouridine (aqueous solution)
- CBNumber:
- CB6748654
- Molecular Formula:
- C9H16N2O6
- Molecular Weight:
- 248.23
- MDL Number:
- MFCD00063468
- MOL File:
- 18771-50-1.mol
| Melting point | >195°C (dec.) |
|---|---|
| Boiling point | 668.6±55.0 °C(Predicted) |
| Density | 1.622±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,2-8°C |
| solubility | Methanol (Slightly), Water (Slightly) |
| form | Solid |
| pka | 12.50±0.40(Predicted) |
| color | White to Off-White |
| Stability | Light Sensitive |
| NCI Dictionary of Cancer Terms | tetrahydrouridine |
| FDA UNII | 0NIZ8H6OL8 |
| NCI Drug Dictionary | tetrahydrouridine |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
Tetrahydrouridine price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 584223 | InSolution Tetrahydrouridine - CAS 18771-50-1 - Calbiochem Tetrahydrouridine is a potent competitive inhibitor of cytidine deaminase. | 18771-50-1 | 25mg | $318 | 2024-03-01 | Buy |
| Sigma-Aldrich | 584222 | Tetrahydrouridine - CAS 18771-50-1 - Calbiochem | 18771-50-1 | 10mg | $226 | 2024-03-01 | Buy |
| Cayman Chemical | 16402 | Tetrahydrouridine ≥80% | 18771-50-1 | 10mg | $163 | 2024-03-01 | Buy |
| Cayman Chemical | 16402 | Tetrahydrouridine | 18771-50-1 | 25mg | $345 | 2024-03-01 | Buy |
| Cayman Chemical | 16402 | Tetrahydrouridine | 18771-50-1 | 50mg | $649 | 2024-03-01 | Buy |
Tetrahydrouridine Chemical Properties,Uses,Production
Description
Tetrahydrouridine is a competitive, reversible inhibitor of cytidine deaminase (Ki values = 54 and 240 nM for human and E. coli enzymes, respectively).Its use, alone or in combination with the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine, is being evaluated in animal models and clinical trials for diseases, including cancer and mitochondrial DNA depletion syndrome.
Laboratory Procedures
Tetrahydrouridine is supplied as a crystalline solid. A stock solution may be made by dissolving the tetrahydrouridine in the solvent of choice. Tetrahydrouridine is soluble in organic solvents such as DMSO and dimethyl formamide, which should be purged with an inert gas. The solubility of tetrahydrouridine in these solvents is approximately 10 and 16 mg/ml, respectively.
Further dilutions of the stock solution into aqueous buffers or isotonic saline should be made prior to performing biological experiments. Ensure that the residual amount of organic solvent is insignificant, since organic solvents may have physiological effects at low concentrations. Organic solvent-free aqueous solutions of tetrahydrouridine can be prepared by directly dissolving the crystalline solid in aqueous buffers. The solubility of tetrahydrouridine in PBS, pH 7.2, is approximately 5 mg/ml. We do not recommend storing the aqueous solution for more than one day.
Description
Tetrahydrouridine is a competitive, reversible inhibitor of cytidine deaminase (Ki values = 54 and 240 nM for human and E. coli enzymes, respectively). Its use, alone or in combination with the DNA methyltransferase inhibitor 5-fluoro-2’-deoxycytidine, is being evaluated in animal models and clinical trials for diseases, including cancer and mitochondrial DNA depletion syndrome.
Uses
3,4,5,6-Tetrahydrouridine, is a derivative of Uridine (U829910). Tetrahydrouridine (THU), is a potent inhibitor of cytidine. It inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels deaminase (CDA), and thus can be used as a potential and promising treatment for tumors with highly expressed CDA.
Tetrahydrouridine Preparation Products And Raw materials
Raw materials
Preparation Products
Tetrahydrouridine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TopScience Biochemical | 00852-68527855 | info@itopbiochem.com | China Hong Kong | 902 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 12477 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| NewCan Biotech Limited | +86-0571-86912261 +8613735419629 | sales@newcanbio.com | China | 10027 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19994 | 58 |
| Shandong Zhishang New Material Co., Ltd. | +8617653113209 | sales002@sdzschem.com | China | 3050 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| China National Standard Pharmaceutical Corporation Limited | +8615391658522 | overseasales@yongstandards.com | China | 11927 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 11013 | 58 |
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