VESNARINONE
- CAS No.
- 81840-15-5
- Chemical Name:
- VESNARINONE
- Synonyms
- Arkin;CS-2139;0PC-8212;OPC 8212;VESNARINONE;Piteranometozine;Vesnarinone(OPC8212);VESNARINONE USP/EP/BP;OPC8212;OPC 8212;OPC-8212;6-[4-(3,4-dimethoxybenzoyl)piperazin-1-yl]-3,4-dihydro-1H-quinolin-2-one
- CBNumber:
- CB6750484
- Molecular Formula:
- C22H25N3O4
- Molecular Weight:
- 395.45
- MDL Number:
- MFCD00867124
- MOL File:
- 81840-15-5.mol
- MSDS File:
- SDS
Melting point | 238.1-239.5° (Tominaga); mp 238.1-239.8° (Shimizu) |
---|---|
Boiling point | 519.41°C (rough estimate) |
Density | 1.2414 (rough estimate) |
refractive index | 1.6500 (estimate) |
storage temp. | Store at -20°C |
solubility |
DMSO:9.84(Max Conc. mg/mL);24.88(Max Conc. mM) DMSO:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.26(Max Conc. mM) DMF:3.0(Max Conc. mg/mL);7.59(Max Conc. mM) |
form | A crystalline solid |
pka | 2.86(at 25℃) |
FDA UNII | 5COW40EV8M |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302-H315-H319-H335 | |||||||||
Precautionary statements | P261-P305+P351+P338 | |||||||||
NFPA 704 |
|
VESNARINONE price More Price(17)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 23489 | Vesnarinone ≥98% | 81840-15-5 | 1mg | $32 | 2024-03-01 | Buy |
Cayman Chemical | 23489 | Vesnarinone ≥98% | 81840-15-5 | 5mg | $139 | 2024-03-01 | Buy |
Cayman Chemical | 23489 | Vesnarinone ≥98% | 81840-15-5 | 10mg | $243 | 2024-03-01 | Buy |
Cayman Chemical | 23489 | Vesnarinone ≥98% | 81840-15-5 | 25mg | $533 | 2024-03-01 | Buy |
ChemScene | CS-5387 | Vesnarinone 96.06% | 81840-15-5 | 100mg | $750 | 2021-12-16 | Buy |
VESNARINONE Chemical Properties,Uses,Production
Description
Vesnarinone is a new orally-active positive inotropic agent introduced for the treatment of congestive heart failure. It exerts a positive inotropic effect on the heart and has a peripheral vasodilatory effect. Vesnarinone is claimed not to affect heart rate or aggravate arrhythmia.
Description
Vesnarinone is an inhibitor of phosphodiesterase 3 (PDE3; IC50s = 10.7 and 13.2 μM for PDE3A and PDE3B, respectively). It also inhibits ether-a-go-go-related gene 1 (ERG1) channels (IC50 = 1.1 μM in HEK293T cells expressing human ERG1). Vesnarinone (3-300 μM) increases contractile tension in isolated ventricular muscles of dog, cat, rabbit, and guinea pig in a dose-dependent manner. Oral and i.v. administration of vesnarinone increases right ventricular pressure with no effect on heart rate in dog models of tricuspid insufficiency- and pulmonary stenosis-induced congestive heart failure. It also increases contractility and coronary flow while decreasing heart rate in a guinea pig model of aortic stenosis-induced congestive heart failure. Formulations containing vesnarinone have been used for the treatment of congestive heart failure.
Originator
Otsuka (Japan)
Uses
Cardiotonic.
Definition
ChEBI: Arkin (TN) is an organic molecular entity.
brand name
Arkin (Otsuka America);Arkin-Z.
VESNARINONE Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-18789408387 | 1057@dideu.com | China | 3834 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9604 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29525 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 | admin@jiuzhou-chem.com;jamie@jiuzhou-chem.com;alice@jiuzhou-chem.com | China | 20000 | 58 |
View Lastest Price from VESNARINONE manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2021-08-13 | VESNARINONE USP/EP/BP
81840-15-5
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited | ||
2020-05-12 | Vesnarinone
81840-15-5
|
US $1.00 / KG | 1KG | 99% | 20T | Shaanxi Dideu Medichem Co. Ltd |
- VESNARINONE USP/EP/BP
81840-15-5
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
- Vesnarinone
81840-15-5
- US $1.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
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