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VESNARINONE

VESNARINONE structure

CAS No.: 81840-15-5

Chemical Name:: VESNARINONE

Synonyms: Arkin;CS-2139;0PC-8212;OPC 8212;VESNARINONE;Piteranometozine;Vesnarinone(OPC8212);VESNARINONE USP/EP/BP;OPC8212;OPC 8212;OPC-8212;6-[4-(3,4-dimethoxybenzoyl)piperazin-1-yl]-3,4-dihydro-1H-quinolin-2-one

CBNumber:: CB6750484

Molecular Formula:: C22H25N3O4

Molecular Weight:: 395.45

MDL Number:: MFCD00867124

MOL File:: 81840-15-5.mol

MSDS File:: SDS

Last updated:2023-06-08 09:02:53

Request For Quotation

VESNARINONE Properties

Melting point	238.1-239.5° (Tominaga); mp 238.1-239.8° (Shimizu)
Boiling point	519.41°C (rough estimate)
Density	1.2414 (rough estimate)
refractive index	1.6500 (estimate)
storage temp.	Store at -20°C
solubility	DMSO:9.84(Max Conc. mg/mL);24.88(Max Conc. mM) DMSO:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.26(Max Conc. mM) DMF:3.0(Max Conc. mg/mL);7.59(Max Conc. mM)
form	A crystalline solid
pka	2.86(at 25℃)
FDA UNII	5COW40EV8M

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P305+P351+P338

NFPA 704

	0
3		0

VESNARINONE price More Price(17)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	23489	Vesnarinone ≥98%	81840-15-5	1mg	$32	2024-03-01	Buy
Cayman Chemical	23489	Vesnarinone ≥98%	81840-15-5	5mg	$139	2024-03-01	Buy
Cayman Chemical	23489	Vesnarinone ≥98%	81840-15-5	10mg	$243	2024-03-01	Buy
Cayman Chemical	23489	Vesnarinone ≥98%	81840-15-5	25mg	$533	2024-03-01	Buy
ChemScene	CS-5387	Vesnarinone 96.06%	81840-15-5	100mg	$750	2021-12-16	Buy

Product number	Packaging	Price	Buy
23489	1mg	$32	Buy
23489	5mg	$139	Buy
23489	10mg	$243	Buy
23489	25mg	$533	Buy
CS-5387	100mg	$750	Buy

VESNARINONE Chemical Properties,Uses,Production

Description

Vesnarinone is a new orally-active positive inotropic agent introduced for the treatment of congestive heart failure. It exerts a positive inotropic effect on the heart and has a peripheral vasodilatory effect. Vesnarinone is claimed not to affect heart rate or aggravate arrhythmia.

Description

Vesnarinone is an inhibitor of phosphodiesterase 3 (PDE3; IC₅₀s = 10.7 and 13.2 μM for PDE3A and PDE3B, respectively). It also inhibits ether-a-go-go-related gene 1 (ERG1) channels (IC₅₀ = 1.1 μM in HEK293T cells expressing human ERG1). Vesnarinone (3-300 μM) increases contractile tension in isolated ventricular muscles of dog, cat, rabbit, and guinea pig in a dose-dependent manner. Oral and i.v. administration of vesnarinone increases right ventricular pressure with no effect on heart rate in dog models of tricuspid insufficiency- and pulmonary stenosis-induced congestive heart failure. It also increases contractility and coronary flow while decreasing heart rate in a guinea pig model of aortic stenosis-induced congestive heart failure. Formulations containing vesnarinone have been used for the treatment of congestive heart failure.

Originator

Otsuka (Japan)

Uses

Cardiotonic.

Definition

ChEBI: Arkin (TN) is an organic molecular entity.

brand name

Arkin (Otsuka America);Arkin-Z.

VESNARINONE Preparation Products And Raw materials

Raw materials

4-Methylanisole 3,4-DIHYDROQUINOLIN-2(1H)-ONE Piperazine Formamide

Preparation Products

VESNARINONE Suppliers

Global( 74)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Shaanxi Dideu Medichem Co. Ltd	+86-029-81138252 +86-18789408387	1057@dideu.com	China	3834	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	9604	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29525	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
ZHEJIANG JIUZHOU CHEM CO., LTD	+86-0576225566889 +86-13454675544	admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com	China	20000	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Shaanxi Dideu Medichem Co. Ltd	58
Shaanxi Dideu Medichem Co. Ltd	58
Dideu Industries Group Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
Nantong HI-FUTURE Biology Co., Ltd.	58
TargetMol Chemicals Inc.	58
ZHEJIANG JIUZHOU CHEM CO., LTD	58

View Lastest Price from VESNARINONE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-08-13	VESNARINONE USP/EP/BP 81840-15-5	US $1.10 / g	1g	99.9%	100 Tons min	Dideu Industries Group Limited
	2020-05-12	Vesnarinone 81840-15-5	US $1.00 / KG	1KG	99%	20T	Shaanxi Dideu Medichem Co. Ltd

VESNARINONE USP/EP/BP
81840-15-5
US $1.10 / g
99.9%
Dideu Industries Group Limited

Vesnarinone
81840-15-5
US $1.00 / KG
99%
Shaanxi Dideu Medichem Co. Ltd

81840-15-5(VESNARINONE)Related Search:

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(4-HYDROXY-PHENYL)-PIPERAZIN-1-YL-METHANONE ETHAMIVAN 1-(4-METHOXYBENZOYL)-PIPERAZINE VESNARINONE 1-[4-(4-AMINO-PHENYL)-PIPERAZIN-1-YL]-ETHANONE

6-AMINO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE 6''-AMINO-1,2,3,4-TETRAHYDROQUINOLINE 4-(4-BENZYLPIPERAZINO)ANILINE (3-METHOXY-PHENYL)-PIPERAZIN-1-YL-METHANONE 2-METHYL-4-(4-METHYLPIPERAZIN-1-YL)ANILINE

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3，4-Dihydro-6-[4-(3，4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)-quinolinone VESNARINONE Arkin Piteranometozine OPC 8212 6-[4-(3,4-Dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydro-2(1H)-quinolinone 0PC-8212 Vesnarinone(OPC8212) OPC8212;OPC 8212;OPC-8212 CS-2139 6-[4-(3,4-dimethoxybenzoyl)piperazin-1-yl]-3,4-dihydro-1H-quinolin-2-one VESNARINONE USP/EP/BP 2(1H)-Quinolinone, 6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydro- OPC8212,phosphodiesterase 3,Inhibitor,OSC5,OPC 8212,oral activity,OSC4,OSC3,positive inotropic activity,Vesnarinone,heart failure,inhibit,Phosphodiesterase (PDE) 6-(4-(3,4-Dimethoxybenzoyl)piperazin-1-yl)-3,4-dihydroquinolin-2(1H)-one 81840-15-5