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GRAMICIDIN C

GRAMICIDIN C structure

CAS No.: 113-73-5

Chemical Name:: GRAMICIDIN C

Synonyms: GRAMICIDIN S;Gramicidin S-A;GRAMICIDIN C;Gramicidin S1;Soviet Gramicidin C;Cyclo(L-Val-L-Orn-L-Leu-D-Phe-L-Pro-L-Val-L-Orn-L-Leu-D-Phe-L-Pro-);Cyclo(L-Leu-D-Phe-L-Pro-L-Val-L-Orn-L-Leu-D-Phe-L-Pro-L-Val-L-Orn-);HCO-X-GLY-L-ALA-D-LEU-L-ALA-D-VAL-L-VAL-D-VAL-L-TRP-D-LEU-L-PHE-D-LEU-L-TRP-D-LEU-L-TRP-NHCH2CH2OH

CBNumber:: CB6759311

Molecular Formula:: C60H92N12O10

Molecular Weight:: 1141.45

MDL Number:: MFCD00466945

MOL File:: 113-73-5.mol

MSDS File:: SDS

Last updated:2024-03-16 16:36:11

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GRAMICIDIN C Properties

Melting point	265-270 °C (decomp)(Solv: ethanol (64-17-5); ethyl ether (60-29-7))
Boiling point	827.42°C (rough estimate)
Density	1.0265 (rough estimate)
refractive index	1.6000 (estimate)
pka	13.00±0.70(Predicted)
Water Solubility	0.14g/L(28 ºC)
InChIKey	IUAYMJGZBVDSGL-XNNAEKOYSA-N
EWG's Food Scores	1
FDA UNII	WHM29QA23F

GRAMICIDIN C price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
American Custom Chemicals Corporation	MTB0002151	GRAMICIDIN C 95.00%	113-73-5	5MG	$503.54	2021-12-16	Buy

Product number	Packaging	Price	Buy
MTB0002151	5MG	$503.54	Buy

GRAMICIDIN C Chemical Properties,Uses,Production

Description

Gramicidin S was found in the culture broth of Bacillus brevis by Gause of the USSR Academy of Medical Sciences in 1944. It was later found by Otani of Osaka University in the cells of the Nagano strain of the same species. The antibiotic is a basic peptide showing strong activity against gram-positive bacteria and considerable activity against gramnegative cocci and Mycobacterium. Gramicidin S is rather toxic but is not absorbed orally; it is used topically as an ointment or as eye or ear drops in combination with other antibacterial drugs.

Originator

Gramoderm,Schering,US,1949

Definition

A cyclic peptide that acts on gram-positive bacteria.

Manufacturing Process

5 lb of acid precipitated solid (Hotchkiss, Advances in Enzymology, pages 157- 158) from 30 gal of tyrothricin fermentation liquor containing about 40 g (2%)of tyrothricin were extracted with 12 liters of absolute ethyl alcohol and filtered. The filtrate was evaporated in vacuo to 1 liter, and the concentrate extracted twice with 1 liter of pentane. The pentane layers were discarded.40 g of decolorizing charcoal were added to the pentane-extracted filtrate and filtered off.
To 500 ml of the charcoal-treated filtrate were added 200 ml benzene and 300 ml water, the whole shaken thoroughly, centrifuged, and the benzene layer separated. This treatment of the charcoal-treated filtrate was repeated twice, all benzene fractions were combined and evaporated in vacuo.
200 ml of absolute acetone were added to the residue and concentrated by boiling to 150 ml. The concentrate was refrigerated overnight. The crystals which had formed in the concentrate were filtered off, and the mother liquor concentrated first to 50 ml and then to 25 ml, the two concentrates refrigerated overnight, and the formed crystals filtered off. Total yield of crystalline gramicidin was 3.85 g = 19.2% of estimated tyrothricin in the initial material.
The combined crystal crops were redissolved in 50 ml absolute acetone, and the solution refrigerated overnight. After filtering, the formed crystals were dried in vacuo. The total yield of crystalline gramicidin thus obtained was 2.5 g.

Therapeutic Function

Antibacterial

Purification Methods

Gramicidin S crystallises from EtOH. The di-HCl crystallises from EtOH (+ few drops of HCl) with m 277-278o (see below). [NMR: Gibbons et al. Nature 227 840 1970, Beilstein 26 III/IV 4273.]

GRAMICIDIN C Preparation Products And Raw materials

Raw materials

Benzene Pentane Acetone Ethanol Trichloroethanol

Preparation Products

GRAMICIDIN C Suppliers

Global( 42)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
BOC Sciences	+16314854226	inquiry@bocsci.com	United States	19743	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
TopScience Biochemical	00852-68527855	info@itopbiochem.com	China Hong Kong	902	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
Alfa Chemistry	+1-5166625404	Info@alfa-chemistry.com	United States	21317	58
Hebei Duling International Trade Co. LTD	+8618032673083	sales05@hbduling.cn	China	15747	58
Hebei Miaoyin Technology Co.,Ltd	+86-17367732028 +86-17367732028	kathy@hbyinsheng.com	China	3582	58
Zhejiang Hangyu API Co., Ltd	+8617531972939	anna@api-made.com	China	2944	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58

Supplier	Advantage
BOC Sciences	58
Henan Tianfu Chemical Co.,Ltd.	55
TopScience Biochemical	58
career henan chemical co	58
Zhejiang J&C Biological Technology Co.,Limited	58
Alfa Chemistry	58
Hebei Duling International Trade Co. LTD	58
Hebei Miaoyin Technology Co.,Ltd	58
Zhejiang Hangyu API Co., Ltd	58
LEAPCHEM CO., LTD.	58

View Lastest Price from GRAMICIDIN C manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2023-04-27	GRAMICIDIN C 113-73-5	US $50.00 / kg	1kg	99%	5000 tons	Hebei Duling International Trade Co. LTD
	2020-02-13	GRAMICIDIN C 113-73-5	US $7.00 / KG	1KG	99%	100KG	Career Henan Chemical Co

GRAMICIDIN C
113-73-5
US $50.00 / kg
99%
Hebei Duling International Trade Co. LTD

GRAMICIDIN C
113-73-5
US $7.00 / KG
99%
Career Henan Chemical Co

113-73-5(GRAMICIDIN C)Related Search:

Bacitracin GRAMICIDIN GRAMICIDIN GRAMICIDIN C

GRAMICIDIN C HCO-X-GLY-L-ALA-D-LEU-L-ALA-D-VAL-L-VAL-D-VAL-L-TRP-D-LEU-L-PHE-D-LEU-L-TRP-D-LEU-L-TRP-NHCH2CH2OH Cyclo(L-Leu-D-Phe-L-Pro-L-Val-L-Orn-L-Leu-D-Phe-L-Pro-L-Val-L-Orn-) Cyclo(L-Val-L-Orn-L-Leu-D-Phe-L-Pro-L-Val-L-Orn-L-Leu-D-Phe-L-Pro-) Gramicidin S1 Soviet Gramicidin C GRAMICIDIN S Gramicidin S-A 113-73-5 C60H92N12O10