2,3-Dichlorophenylboronic acid
- CAS No.
- 151169-74-3
- Chemical Name:
- 2,3-Dichlorophenylboronic acid
- Synonyms
- AKOS BRN-0159;CAS:151169-74-3;RARECHEM AH PB 0262;3,4-Dichlorophenylboric acid;2,3-Dichlorophenylboronicaci;2,3-Dichloropheyl Boronic Acid;2,3-DICHLOROPHENYLBORONIC ACID;2,3-Dichlorophenylbrornic acid;2,3-DICHLOROBENZENEBORONIC ACID;B-(2,3-Dichlorophenyl)boronic acid
- CBNumber:
- CB6768276
- Molecular Formula:
- C6H5BCl2O2
- Molecular Weight:
- 190.82
- MDL Number:
- MFCD01075703
- MOL File:
- 151169-74-3.mol
- MSDS File:
- SDS
| Melting point | 125 °C (dec.) (lit.) |
|---|---|
| Boiling point | 349.8±52.0 °C(Predicted) |
| Density | 1.47±0.1 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | Soluble in methanol. |
| form | Powder |
| pka | 7.26±0.58(Predicted) |
| color | White |
| InChI | InChI=1S/C6H5BCl2O2/c8-5-3-1-2-4(6(5)9)7(10)11/h1-3,10-11H |
| InChIKey | TYIKXPOMOYDGCS-UHFFFAOYSA-N |
| SMILES | B(C1=CC=CC(Cl)=C1Cl)(O)O |
| CAS DataBase Reference | 151169-74-3(CAS DataBase Reference) |
| UNSPSC Code | 12352103 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 36/37/38-22 | |||||||||
| Safety Statements | 37/39-26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29319090 | |||||||||
| NFPA 704 |
|
2,3-Dichlorophenylboronic acid price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 514047 | 2,3-Dichlorophenylboronic acid | 151169-74-3 | 5g | $57 | 2023-06-20 | Buy |
| Sigma-Aldrich | 514047 | 2,3-Dichlorophenylboronic acid | 151169-74-3 | 25g | $219 | 2023-06-20 | Buy |
| TCI Chemical | D3434 | 2,3-Dichlorophenylboronic Acid (contains varying amounts of Anhydride) | 151169-74-3 | 5g | $63 | 2025-07-31 | Buy |
| TCI Chemical | D3434 | 2,3-Dichlorophenylboronic Acid (contains varying amounts of Anhydride) | 151169-74-3 | 25g | $206 | 2025-07-31 | Buy |
| TRC | D436600 | 2,3-Dichlorophenylboronic acid | 151169-74-3 | 25g | $250 | 2021-12-16 | Buy |
2,3-Dichlorophenylboronic acid Chemical Properties,Uses,Production
Chemical Properties
white powder
Uses
suzuki reaction
Uses
2,3-Dichlorophenylboronic Acid is used as a reagent in the synthesis of trisubstituted thiazoles as Cdc7 kinase inhibitors. It is also used as a reagent in the synthesis of aminoarylpyridazines as selective CB2 agonists for treatment of inflammatory pain.
Synthesis
121-43-7
56961-77-4
151169-74-3
1. A solution was prepared by dissolving 1-bromo-2,3-dichlorobenzene (20 g, 0.088 mol, Aldrich) in anhydrous tetrahydrofuran (44.24 ml) under the protection of dry inert gas. 2. The above solution was slowly added dropwise to anhydrous tetrahydrofuran (16 ml) of n-butyllithium (1.6 M in hexane, 66.36 ml, 0.11 mol) solution, with the reaction temperature strictly controlled below -65°C. 3. After the dropwise addition, the light yellow suspension formed was stirred continuously at -78°C for 75 min. 4. Trimethyl borate (13.28 ml, 12.16 g, 0.12 mol) was slowly added while keeping the temperature below -55°C. 5. The reaction mixture was gradually warmed up to room temperature and stirred overnight. 6. Excess n-butyllithium was quenched with water (30 ml) and the reaction mixture was subsequently concentrated under reduced pressure.7. The concentrated residue was suspended in water and acidified with 2M hydrochloric acid (10 ml).8. The insoluble solid was collected by filtration, washed well with water and then dried.9. The dried solid was suspended in petroleum ether at 60-80°C, stirred at room temperature for 10 min, filtered and dried under vacuum.10. Finally, 8.42 g of 2,3-dichlorophenylboronic acid was obtained in 50% yield with a melting point of 235-238 °C.
References
[1] Patent: US6255307, 2001, B1
2,3-Dichlorophenylboronic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29734 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13091 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29852 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | marketing1@neostarunited.com | China | 8826 | 58 |
View Lastest Price from 2,3-Dichlorophenylboronic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-04-24 | 2,3-Dichlorophenylboronic acid
151169-74-3
|
US $0.00 / kg | 1kg | ≥99.0% | 1000kg | Hebei Maison Chemical Co.,Ltd. | |
 |
2019-07-06 | 2,3-Dichlorophenylboronic acid
151169-74-3
|
US $1.00 / KG | 1KG | 98%-100% | 1 | Career Henan Chemical Co |
-
- 2,3-Dichlorophenylboronic acid
151169-74-3
- US $0.00 / kg
- ≥99.0%
- Hebei Maison Chemical Co.,Ltd.
-
- 2,3-Dichlorophenylboronic acid
151169-74-3
- US $1.00 / KG
- 98%-100%
- Career Henan Chemical Co
