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ORPHENADRINE HYDROCHLORIDE

CAS No.
341-69-5
Chemical Name:
ORPHENADRINE HYDROCHLORIDE
Synonyms
BF 5930;BG 5930;BS 5930;Mebedrol;Mephenamin;Brocasipal;Mephenamine;Brocadisipal;mephenaminforte;Mephenamin forte
CBNumber:
CB6782740
Molecular Formula:
C18H24ClNO
Molecular Weight:
305.84
MDL Number:
MFCD00012480
MOL File:
341-69-5.mol
MSDS File:
SDS
Last updated:2023-06-08 09:02:57

ORPHENADRINE HYDROCHLORIDE Properties

Melting point 159.0 to 164.0 °C
Boiling point -195 °C
Density 0.295 g/cm3
storage temp. 2-8°C
solubility Freely soluble in water and in ethanol (96 per cent).
color Crystals
BRN 3745818
Stability Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference 341-69-5(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII UBY910DUXH
EPA Substance Registry System Orphenadrine hydrochloride (341-69-5)

Pharmacokinetic data

Protein binding 95%
Excreted unchanged in urine 8%
Biological half-life 14 / -

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P301+P310
Hazard Codes  Xn
Risk Statements  22
Safety Statements  36
RIDADR  3249
WGK Germany  3
RTECS  KR6300000
HazardClass  6.1(b)
PackingGroup  III
Toxicity LD50 oral in rat: 255mg/kg
NFPA 704
0
2 0

ORPHENADRINE HYDROCHLORIDE price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Y0000100 Orphenadrine hydrochloride European Pharmacopoeia (EP) Reference Standard 341-69-5 y0000100 $150 2024-03-01 Buy
Sigma-Aldrich 75517 Orphenadrine hydrochloride 99% 341-69-5 5g $64.2 2024-03-01 Buy
Cayman Chemical 26391 Orphenadrine (hydrochloride) 341-69-5 10mg $49 2024-03-01 Buy
Cayman Chemical 26391 Orphenadrine (hydrochloride) 341-69-5 25mg $115 2024-03-01 Buy
Sigma-Aldrich Y0001181 Orphenadrine for peak identification European Pharmacopoeia (EP) Reference Standard 341-69-5 y0001181 $203 2024-03-01 Buy
Product number Packaging Price Buy
Y0000100 y0000100 $150 Buy
75517 5g $64.2 Buy
26391 10mg $49 Buy
26391 25mg $115 Buy
Y0001181 y0001181 $203 Buy

ORPHENADRINE HYDROCHLORIDE Chemical Properties,Uses,Production

Chemical Properties

White or almost white, crystalline powder.

Uses

Antihistaminic;H1 antogonist

Definition

ChEBI: A hydrochloride comprising equimolar amounts of ophenadrine and hydrogen chloride.

General Description

Odorless white or almost white crystalline powder. pH (aqueous solution) about 5.5. Bitter numbing taste.

Air & Water Reactions

May be sensitive to prolonged exposure to light and air. Water soluble.

Reactivity Profile

ORPHENADRINE HYDROCHLORIDE is incompatible with strong oxidizers.

Fire Hazard

Flash point data for ORPHENADRINE HYDROCHLORIDE are not available; however, ORPHENADRINE HYDROCHLORIDE is probably combustible.

Biochem/physiol Actions

Muscarinic receptor antagonist; H1 histamine receptor antagonist; muscle relaxant. Orphenadrine has also been reported to inhibit the noradrenergic transporter and to block the NMDA receptor ion channel.

Clinical Use

Anti-muscarinic:
Parkinsonism
Drug induced extra-pyramidal symptoms

Safety Profile

Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Human systemic effects: mydriasis @updlaryd ilation), hallucinations, distorted perceptions, pulse rate increase, intracranial pressure increase. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and HCl

Metabolism

Orphenadrine is almost completely metabolised to at least 8 metabolites in the liver.
It is mainly excreted in the urine as metabolites and small amounts of unchanged drug

ORPHENADRINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 111)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Dideu Medichem Co. Ltd
18192627656 1012@dideu.com China 3911 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Career Henan Chemica Co
+86-0371-86658258 15093356674; laboratory@coreychem.com China 30256 58
Xi'an MC Biotech, Co., Ltd.
029-89275612 +8618991951683 mcbio_sales@163.com China 2255 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250 1026@dideu.com China 29831 58
Alfa Chemistry
+1-5166625404 Info@alfa-chemistry.com United States 21317 58
Hangzhou MolCore BioPharmatech Co.,Ltd.
+86-057181025280; +8617767106207 sales@molcore.com China 49739 58
GIHI CHEMICALS CO.,LIMITED
+8618058761490 info@gihichemicals.com China 50001 58
LEAPCHEM CO., LTD.
+86-852-30606658 market18@leapchem.com China 43348 58
Shanghai Acmec Biochemical Technology Co., Ltd.
+undefined18621343501 product@acmec-e.com China 33349 58

View Lastest Price from ORPHENADRINE HYDROCHLORIDE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ORPHENADRINE HYDROCHLORIDE  pictures 2022-08-24 ORPHENADRINE HYDROCHLORIDE
341-69-5
US $1.10 / g 1g 99.00% 100 Tons Min Dideu Industries Group Limited
Orphenadrine hydrochloride   pictures 2020-03-16 Orphenadrine hydrochloride
341-69-5
US $1.00-0.00 / KG 1KG 99% 200000KG Shaanxi Dideu Medichem Co. Ltd

ORPHENADRINE HYDROCHLORIDE Spectrum

2-Dimethylaminoethyl 2-methylbenzhydryl ether hydrochloride Ethanamine, N,N-dimethyl-2-[(2-methylphenyl)phenylmethoxy]-, hydrochloride Ethylamine, N,N-dimethyl-2-((o-methyl-alpha-phenylbenzyl)oxy)-, hydrochloride Ethylamine, N,N-dimethyl-2-(alpha-(o-tolyl)benzyloxy)-, hydrochloride Ethylamine, N,N-dimethyl-2-(phenyl-(o-tolyl)methoxy)-, hydrochloride Mebedrol Mefenamin hydrochloride Mephenamin Mephenamin forte Mephenamin hydrochloride Mephenamine Mephenamine hydrochloride mephenaminehydrochloride mephenaminforte mephenaminhydrochloride Orphenadrine hydrochloride >=98.0% (AT) EthanaMine,N,N-diMethyl-2-[(2-Methylphenyl)phenylMethoxy]-, hydrochloride (1:1) Orph·Nadrine hydrochloride 2-dimethylaminoethyl2-methylbenzhydryletherhydrochloride BF 5930 BG 5930 Brocadisipal Brocasipal BS 5930 Disipal hydrochloride disipalhydrochloride n,n-dimethyl-2-(o-methyl-alpha-phenylbenzyloxy)ethylaminehydrochloride Orfenadrin hydrochloride orfenadrinhydrochloride Orphenedrine hydrochloride 2-(PHENYL-O-TOLYLMETHOXY)ETHYLDIMETHYLAMINE HYDROCHLORIDE ORPHENADRINE HCL ORPHENADRINE HYDROCHLORIDE O-METHYLDIPHENHYDRAMINE HYDROCHLORIDE N,N-DIMETHYL-2-(2-METHYLBENZHYDRYLOXY)-ETHYLAMINE HYDROCHLORIDE B-DIMETHYLAMINOETHYL 2-METHYLBENZHYDRYL ETHER HYDROCHLORIDE n,n-dimethyl-2-((o-methyl-alpha-phenylbenzyl)oxy)-ethylaminhydrochloride N,N-Dimethyl-2-(alpha-(o-tolyl)benzyloxy)ethylamine hydrochloride N,N-Dimethyl-2-(o-methyl-alpha-phenylbenzyloxy)ethylamine hydrochloride o-Methyldiphenhydramine hydrochloride, N,N-Dimethyl-2-(2-methylbenzhydryloxy)ethylamine hydrochloride, β-Dimethylaminoethyl 2-methylbenzhydryl ether hydrochloride Orphenadrine hydrochloride,99% Orphenadrine hydrochloride CRS OrphenadrineHydrochloride> ORPHENADRINE HYDROCHLORIDE ISO 9001:2015 REACH Ionotropic glutamate receptors,Orphenadrine hydrochloride,spasticity,HSP27,parkinson's syndrome,PBR,Inhibitor,inhibit,CGC cells,iGluR,neuroprotective properties,Orphenadrine Phenylbutazone Impurity 20 341-69-5 C18H23NOHCl Building Blocks Amine Salts Nitrogen Compounds Organic Building Blocks API