ChemicalBook >> CAS DataBase List >>SHMT-IN-1

SHMT-IN-1

CAS No.
1508286-18-7
Chemical Name:
SHMT-IN-1
Synonyms
SHMT-IN-1;SHMT IN 1,SHMTIN1;6-Amino-4-cyclobutyl-4-(3,5-dichlorophenyl)-1,4-dihydro-3-methylpyrano[2,3-c]pyrazole-5-carbonitrile;Pyrano[2,3-c]pyrazole-5-carbonitrile, 6-amino-4-cyclobutyl-4-(3,5-dichlorophenyl)-1,4-dihydro-3-methyl-
CBNumber:
CB68054540
Molecular Formula:
C18H16Cl2N4O
Molecular Weight:
375.25
MDL Number:
MFCD34469611
MOL File:
1508286-18-7.mol
Last updated:2023-09-04 15:50:00

SHMT-IN-1 Properties

Boiling point 634.6±55.0 °C(Predicted)
Density 1.49±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 250 mg/mL (666.22 mM; Need ultrasonic)
pka 11.46±0.70(Predicted)

SHMT-IN-1 Chemical Properties,Uses,Production

Biological Activity

SHMT-IN-1 (compound (±)-46) is a potent inhibitor of plasmodial serine hydroxymethyltransferase (SHMT). SHMT-IN-1 has antitumor activity[1].

References

[1]. Witschel MC, et al. Inhibitors of plasmodial serine hydroxymethyltransferase (SHMT): cocrystal structures of pyrazolopyrans with potent blood- and liver-stage activities. J Med Chem. 2015 Apr 9;58(7):3117-30.

SHMT-IN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

SHMT-IN-1 Suppliers

Global( 3)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24131 58
Taizhou GreenChem Pharma-Tech Co.,Ltd 15366892466 greenchem@tzglmk.com China 828 58

SHMT-IN-1 Spectrum

SHMT-IN-1 SHMT IN 1,SHMTIN1 Pyrano[2,3-c]pyrazole-5-carbonitrile, 6-amino-4-cyclobutyl-4-(3,5-dichlorophenyl)-1,4-dihydro-3-methyl- 6-Amino-4-cyclobutyl-4-(3,5-dichlorophenyl)-1,4-dihydro-3-methylpyrano[2,3-c]pyrazole-5-carbonitrile 1508286-18-7