ChemicalBook >> CAS DataBase List >>4-Piperidinecarboxylic acid, 1-[5-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-2-thiazolyl]-

4-Piperidinecarboxylic acid, 1-[5-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-2-thiazolyl]-

4-Piperidinecarboxylic acid, 1-[5-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-2-thiazolyl]- structure

CAS No.: 1331745-61-9

Chemical Name:: 4-Piperidinecarboxylic acid, 1-[5-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-2-thiazolyl]-

Synonyms: ML372;4-Piperidinecarboxylic acid, 1-[5-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-2-thiazolyl]-

CBNumber:: CB68365668

Molecular Formula:: C18H20N2O4S

Molecular Weight:: 360.43

MDL Number:

MOL File:: 1331745-61-9.mol

Last updated:2023-05-21 10:59:17

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4-Piperidinecarboxylic acid, 1-[5-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-2-thiazolyl]- Properties

Boiling point	585.3±60.0 °C(Predicted)
Density	1.341±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
pka	4.23±0.20(Predicted)

4-Piperidinecarboxylic acid, 1-[5-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-2-thiazolyl]- price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
DC Chemicals	DC23748	ML372 >98%	1331745-61-9	10mg	$450	2021-12-16	Buy

Product number	Packaging	Price	Buy
DC23748	10mg	$450	Buy

4-Piperidinecarboxylic acid, 1-[5-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-2-thiazolyl]- Chemical Properties,Uses,Production

Biological Activity

ML372 inhibits survival motor neuron (SMN) protein ubiquitination, increases SMN protein stability without affecting mRNA expression. ML372 improves spinal muscular atrophy (SMA) in mice. ML372 is brain penetrant and has a reasonable exposure and half-life in vivo[1].

References

[1]. Mahlet B Abera, et al. ML372 blocks SMN ubiquitination and improves spinal muscular atrophy pathology in mice. JCI Insight. 2016 Nov 17;1(19):e88427.

4-Piperidinecarboxylic acid, 1-[5-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-2-thiazolyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

4-Piperidinecarboxylic acid, 1-[5-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-2-thiazolyl]- Suppliers

Global( 5)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Beijing Solarbio Science & Tecnology Co., Ltd.	010-50973130 4009686088	3193328036@qq.com	China	29797	68
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9414	58
Block Chemical Technology (Shanghai) Co., Ltd.	021-20432219 13918097649	li_jinfei@acblock-lab.com	China	9913	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24024	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Beijing Solarbio Science & Tecnology Co., Ltd.	68
DC Chemicals	58
Block Chemical Technology (Shanghai) Co., Ltd.	58
TargetMol Chemicals Inc.	58

4-Piperidinecarboxylic acid, 1-[5-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-2-thiazolyl]- ML372 1331745-61-9