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N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE

N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE structure

CAS No.: 123464-89-1

Chemical Name:: N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE

Synonyms: SKL843;CS-1012;PNU 282987;PNU282987 HCl;Lanreotide Autogel;PNU 282987(PNU 282987 hydrochloride);PNU 282987 - CAS 123464-89-1 - Calbiochem;N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE;(R)-4-Chloro-N-(quinuclidin-3-yl)benzamide hydrochloride;N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide hydrochloride

CBNumber:: CB6847535

Molecular Formula:: C14H17ClN2O

Molecular Weight:: 264.75058

MDL Number:: MFCD30207879

MOL File:: 123464-89-1.mol

MSDS File:: SDS

Last updated:2023-09-20 16:43:00

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N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE Properties

Melting point	240-242℃
storage temp.	Inert atmosphere,2-8°C
solubility	Soluble in DMSO (up to 25 mg/ml)
form	Off-white solid
color	White
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
FDA UNII	810P1694K2

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P280a-P304+P340-P305+P351+P338-P405-P501a

N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE price More Price(34)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	5.05278	PNU 282987 - CAS 123464-89-1 - Calbiochem	123464-89-1	10MG	$153	2022-05-15	Buy
Alfa Aesar	J67353	PNU-282987, 99%	123464-89-1	10mg	$158	2021-12-16	Buy
Tocris	2303	PNU282987 ≥98%(HPLC)	123464-89-1	10	$151	2021-12-16	Buy
Tocris	2303	PNU282987 ≥98%(HPLC)	123464-89-1	50	$634	2021-12-16	Buy
TRC	P653468	PNU282987	123464-89-1	250mg	$495	2021-12-16	Buy

Product number	Packaging	Price	Buy
5.05278	10MG	$153	Buy
J67353	10mg	$158	Buy
2303	10	$151	Buy
2303	50	$634	Buy
P653468	250mg	$495	Buy

N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE Chemical Properties,Uses,Production

Description

PNU 282987 (CAS 123464-89-1) is a selective α7 nicotinic acetylcholine receptor (nAChR) agonist (Ki?= 26 nM).1? The?a7 nAChR is a potential therapeutic target of cognitive deficits in diseases such as Alzheimer’s, Parkinson’s, schizophrenia, and attention deficit disorders – agonism of this receptor with PNU 282987 has shown potential to ameliorate these deficits.2-5

Uses

PNU 282987 is used as an activator of α-7 nicotinic acetylcholine receptor.

General Description

A potent agonist highly selective for α7 nAChRs (K_i = 26 nM). Used in investigating the roles of α7 nAChRs in sensory gating, learning and memory, cognitive functions, and treatment of Schizophrenia.

Biological Activity

Highly selective α 7 nAChR agonist (K i = 26 nM) displaying negligible blockade of α 1 β 1 γ δ and α 3 β 4 nAChRs (IC 50 ≥ 60 μ M). Found to be inactive against a panel of 32 receptors at 1 μ M, except 5-HT 3 receptors (K i = 930 nM).

Biochem/physiol Actions

Primary Targetα7 nAChRs

References

1) Bodnar?et al.?(2005),?Discovery and structure-activity relationship of quinuclidine benzamides as agonists of α7 nicotinic acetylcholine receptors; J. Med. Chem.?48?905 2) Stuckenholz?et al.?(2013),?The α7 nAChR agonist PNU-282987 reduces inflammation and MPTP-induced nigral dopaminergic cell loss in mice; J. Parkinsons Dis.?3?161 3) Vicens?et al. (2013),?Motor and anxiety effects of PNU-282987, an alpha7 nicotinic receptor agonist, and stress in an animal model of Alzheimer’s disease; Curr. Alzheimer Res.?10?516 4) Navarro?et al.?(2015),?Alpha7 nicotinic receptor activation protects against oxidative stress via heme-oxygenase I induction; Biochem. Pharmacol.?97?473 5) McLean?et al.?(2016),?Nicotinic α7 and α4β2 agonists enhance the formation and retrieval of recognition memory: Potential mechanisms for cognitive performance enhancement in neurological and psychiatric disorders; Behav. Brain Res.?302?73

N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE Suppliers

Global( 112)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	967	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5738	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24738	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Biochempartner	58
BOC Sciences	58
career henan chemical co	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
LEAP CHEM CO., LTD.	58

View Lastest Price from N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-12-23	N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide 123464-89-1	US $1.00 / KG	1KG	Min98% HPLC	g/kg/ton	Career Henan Chemical Co

N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide
123464-89-1
US $1.00 / KG
Min98% HPLC
Career Henan Chemical Co

N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE Spectrum

N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE(123464-89-1)MS N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE(123464-89-1)¹HNMR

123464-89-1(N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE)Related Search:

Tamoxifen citrate REVERSINE (E)-3-[[[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYL]PHENYL]-[[(3-DIMETHYLAMINO)-3-OXOPROPYL]THIO]METHYL]THIO]-PROPANOIC ACID, SODIUM SALT THIP HYDROCHLORIDE PNU-282987 S enantiomer hydrochloride

Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro- PNU-282987 (S enantiomer free base) 2-amino-N-1-azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide 3-amino-N-1-azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide 2-amino-N-1-azabicyclo[2.2.2]oct-3-yl-5-chlorobenzamide

N1-(1-azabicyclo[2.2.2]oct-3-yl)-3-chlorobenzamide 5-amino-N-1-azabicyclo[2.2.2]oct-3-yl-2-chlorobenzamide 4-amino-N-1-azabicyclo[2.2.2]oct-3-yl-2-chlorobenzamide N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLORO-BENZAMIDE MONOHYDROCHLORIDE HYDRATE N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE

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N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE PNU 282987 N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide hydrochloride N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide hydrochloride PNU 282987 PNU282987 HCl PNU 282987(PNU 282987 hydrochloride) CS-1012 PNU 282987 - CAS 123464-89-1 - Calbiochem SKL843 Lanreotide Autogel (R)-4-Chloro-N-(quinuclidin-3-yl)benzamide hydrochloride 123464-89-1 C14H17ClN2OHCl Inhibitors Acetylcholine receptor