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Isopropyl acetate

Isopropyl acetate
Isopropyl acetate structure
Chemical Name:
Isopropyl acetate
IPAC ;IPrOAc;FEMA 2926;paracetat;CH3COOCH(CH3)2;2-propylacetate;Ispropyl acetat;Isopropylacetat;2-acetoxypropane;2-Propyl acetate
Molecular Formula:
Formula Weight:
MOL File:

Isopropyl acetate Properties

Melting point:
-73 °C
Boiling point:
88.8 °C
0.872 g/mL at 25 °C(lit.)
vapor density 
3.5 (vs air)
vapor pressure 
47 mm Hg ( 20 °C)
refractive index 
n20/D 1.377(lit.)
Flash point:
62 °F
storage temp. 
Store below +30°C.
1 M HCl: soluble50mg/mL, clear to slightly hazy, colorless
Clear colorless
Pleasant, fruity; nonresidual.
Evaporation Rate
Odor Threshold
explosive limit
1.8%, 37°F
Water Solubility 
2.90 g/100 mL
Moisture Sensitive
JECFA Number
Exposure limits
TLV-TWA 250 ppm (~950 mg/m3) (ACGIH, MSHA, and OSHA); TLV-STEL 310 ppm (~1185 mg/m3) (ACGIH); IDLH 16,000 ppm (NIOSH).
Stable. Flammable - note low flash point. Incompatible with strong oxidizing agents, strong acids, nitrates, alkali metals. May attack some plastics and rubber.
CAS DataBase Reference
108-21-4(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS)
172.515; 175.105; 177.1200
EWG's Food Scores
NIST Chemistry Reference
Acetic acid, 1-methylethyl ester(108-21-4)
EPA Substance Registry System
Isopropyl acetate (108-21-4)
  • Risk and Safety Statements
Signal word  Danger
Hazard statements  H332-H335-H225-H319-H336
Precautionary statements  P501a-P210-P305+P351+P338-P370+P378-P403+P235-P233-P240-P241+P242+P243-P261-P264-P271-P280-P303+P361+P353-P304+P340+P312-P305+P351+P338+P337+P313-P403+P233-P405-P501
Hazard Codes  F,Xi
Risk Statements  11-36/37/38-67-66-36
Safety Statements  16-26-36-33-29
RIDADR  UN 1220 3/PG 2
WGK Germany  1
RTECS  AI4930000
Autoignition Temperature 894 °F
HazardClass  3
PackingGroup  II
HS Code  29153900
Toxicity LD50 orally in rats: 6.75 g/kg (Smyth)
NFPA 704
2 0

Isopropyl acetate price More Price(50)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich W292605 Isopropyl acetate ≥99%,FCC 108-21-4 1 SAMPLE-K $50 2021-12-16 Buy
Sigma-Aldrich 8.20560 Isopropyl acetate for synthesis 108-21-4 1 L $66.97 2021-12-16 Buy
Sigma-Aldrich 8.20560 Isopropyl acetate for synthesis 108-21-4 100 mL $37.09 2021-12-16 Buy
Sigma-Aldrich 45960 Isopropyl acetate puriss. p.a., ≥99.5% (GC) 108-21-4 250 mL $44.7 2021-12-16 Buy
Sigma-Aldrich 112992 Isopropyl acetate 98% 108-21-4 1l $115 2021-12-16 Buy

Isopropyl acetate Chemical Properties,Uses,Production


Isopropyl acetate has an intense, fruity odor. On dilution, it has a sweet apple-like flavor. Synthesized by direct acetylation of isopropyl alcohol in the presence of various catalysts: concentrated H2S04, diethyl sulfate, chlorosulfonic acid, and boron trifluoride.

Chemical Properties

Isopropyl acetate has an intense, fruity odor. On dilution, it has a sweet apple-like flavor.

Chemical Properties

colourless liquid with a fruity odour

Physical properties

Clear, colorless liquid with an aromatic odor. Experimentally determined detection and recognition odor threshold concentrations were 2.1 mg/m3 (500 ppbv) and 3.8 mg/m3 (910 ppbv), respectively (Hellman and Small, 1974).


Reported found in pineapple, pear, cocoa, apple, banana, black currants, grapes, melons, strawberry, cheddar cheese, beer, white wine, red wine, cocoa, honey, soybean, yellow passion fruit, beans, plum brandy and nectarines


Solvent for cellulose derivatives, plastics, oils and fats; in perfumery.


Isopropyl acetate is used as a solvent fornitrocellulose, plastics, oils, and fats, and asa flavoring agent. Isopropyl Acetate is a widely used chemical solvent in organic and industrial syntheses. Also used in the dissolution of gallstones. Environmental contaminants; Food contaminants.


Isopropyl acetate is a solvent in chemical industry, especially for cellulose, plastics, waxes, resins, gums, paints, oil and fats. and also as flavoring agent. It is an active component of perfumes and printing inks. It is also employed as an extractant for the preparation of antibiotics, vitamins and hormones.

Production Methods

Isopropyl acetate is prepared from propylene and anhydrous acetic acid in the presence of a catalyst . It may also be produced by reacting isopropyl alcohol with acetic acid in the presence of catalysts .


By direct acetylation of isopropyl alcohol in the presence of various catalysts; concentrated H2SO4, diethyl sulfate, chlorosulfonic acid and boron trifluoride.


ChEBI: A branched-chain saturated fatty acid anion that is the conjugate base of isovaleric acid; reported to improve ruminal fermentation and feed digestion in cattle.

Aroma threshold values

Detection; 1.7 to 4.4 ppm

Taste threshold values

Taste characteristics at 60 ppm: ethereal, tutti-frutti, with a fruity apple and banana nuance

Synthesis Reference(s)

The Journal of Organic Chemistry, 39, p. 3728, 1974 DOI: 10.1021/jo00939a026

General Description

A clear colorless liquid. Flash point 40°F. Vapors are heavier than air. Contact with the material may irritate skin, eyes or mucous membranes. May be toxic by ingestion, inhalation and skin absorption. Used as a solvent.

Air & Water Reactions

Highly flammable. Less dense than water and slightly soluble in water.

Reactivity Profile

Isopropyl acetate is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. Isopropyl acetate can react vigorously with nitrates, strong oxidizers, strong alkalis and strong acids. Isopropyl acetate may also attack some forms of rubber, plastics and coatings. .


Flammable, dangerous fire risk.

Health Hazard

Vapors irritate eyes and respiratory tract; high concentrations can be anesthetic. Liquid irritates eyes but causes no serious injury; may cause dermatitis; no serious effects if swallowed.

Health Hazard

Isopropyl acetate is an irritant to the eyes,nose, and throat. The acute toxicity in laboratory animals was low. Exposure to highconcentrations in air or ingestion can produce narcotic effects. A 4-hour exposure to aconcentration of 32,000 ppm in air was fatalto rats (ACGIH 1986). The oral LD50 valuein rats is in the range 6000 mg/kg.

Fire Hazard

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Chemical Reactivity

Reactivity with Water: No reaction; Reactivity with Common Materials: No reactions; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.


Identified among 139 volatile compounds identified in cantaloupe (Cucumis melo var. reticulates cv. Sol Real) using an automated rapid headspace solid phase microextraction method (Beaulieu and Grimm, 2001).

Environmental Fate

Chemical/Physical. Hydrolyzes in water forming isopropyl alcohol and acetic acid (Morrison and Boyd, 1971). The estimated hydrolysis half-life at 25 °C and pH 7 is 8.4 yr (Mabey and Mill, 1978).
At an influent concentration of 1,000 mg/L, treatment with GAC resulted in an effluent concentration of 319 mg/L. The adsorbability of the carbon used was 137 mg/g carbon (Guisti et al., 1974).

Purification Methods

Wash the acetate with 50% aqueous K2CO3 (to remove acid), then with saturated aqueous CaCl2 (to remove any alcohol). Dry it with CaCl2 and fractionally distil it. [Beilstein 2 IV 141.]

Isopropyl acetate Preparation Products And Raw materials

Raw materials

Preparation Products

16,17-Epoxy-16-methyl pregn-9(11)-en-3-ol-20-one 19-CARBOXYANDROST-4-ENE-3,17-DIONE 1H-PYRROLO[2,3-B]PYRIDINE, 2-METHYL- 5 A-CHLORO-6 B,19-EPOXY-3 B -HYDROXY-5 A-ANDROSTAN-17-ONE 6,9-Difluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 21-acetate 4-(Aminosulfonyl)phenylboronic acid 9-Bromo-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione 21-acetate 4-(2-KETO-1-BENZIMIDAZOLINYL)PIPERIDINE 1-METHANESULFONYL-PIPERAZINE 6alpha,9-difluoro-11beta,21-dihydroxypregna-1,4,16-triene-3,20-dione 21-acetate 5-CHLORO-6 B,19-EPOXY-5A -ANDROTANE-3,17-DIONE Oxendolone Estrone 3-Acetyloxy-16,17-epoxy-16-methylpregn-5-en-20-one 5-Azaindole 3,17,21-Trihydroxypregna-3,5,9(11)-trien-20-one 3,17,21-triacetate Aclatonium napadisilate 9-fluoro-11beta,21-dihydroxypregna-1,4,16-triene-3,20-dione 21-acetate 3,17-Dihydroxy-16-methylpregna-5,15-diene-20-one 3-acetate all-trans-Retinol ironic ion stabiliger CT^{1~7^} Benzyl acetate 19-HYDROXY-4-ANDROSTENE-3,17-DIONE Ethyl N-piperazinecarboxylate Pyridoxine hydrochloride 4-TERT-BUTYL-3-HYDROXY-2,6-DIMETHYLPHENYLACETONITRILE 16,17-Epoxy-3-hydroxy-16-methyl-pregn-9(11)-ene-20-one-3-acetate 9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 21-acetate 17-Ethinylandrost-5-ene-3,17-diol 16,17-Epoxy-3,17-dihydroxyestra-1,3,5(10)-triene-3,17-diacetate Tirofiban 3-Hydroxytyramine hydrochloride Tetrabenzyl pyrophosphate Hydrocortisone 17-hydroxy-6-methylenepregn-4-ene-3,20-dione 17-acetate 9beta,11beta-epoxy-17,21-dihydroxypregn-4-ene-3,20-dione 3beta-hydroxy-5alpha-pregna-9(11),16-dien-20-one 3-acetate

Isopropyl acetate Suppliers

Global( 321)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 China 22607 55
Hangzhou FandaChem Co.,Ltd.
+86-571-56059825 CHINA 9107 55
career henan chemical co
+86-0371-55982848 China 29954 58
+86 18953170293
+86 0531-67809011 CHINA 2940 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282 China 5941 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114 CHINA 6369 58
Hubei xin bonus chemical co. LTD
027-59338440 CHINA 23035 58
Standardpharm Co. Ltd.
86-714-3992388 United States 14344 58
Chongqing Chemdad Co., Ltd
+86-13650506873 CHINA 37282 58
Alchem Pharmtech,Inc.
8485655694 United States 63726 58

View Lastest Price from Isopropyl acetate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-12-01 Isopropyl acetate
US $9.10 / KG 1KG 99.5% 10 ton Hebei Crovell Biotech Co Ltd
2021-11-08 Isopropyl acetate
US $10.00 / g 100g 99% 1000ton/Month Wuhan wingroup Pharmaceutical Co., Ltd
2021-07-03 Isopropyl acetate
US $1.00 / PCS 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.

Isopropyl acetate Spectrum

108-21-4(Isopropyl acetate )Related Search:

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