ChemicalBook >> CAS DataBase List >>2,4,6-Collidine

2,4,6-Collidine

CAS No.
108-75-8
Chemical Name:
2,4,6-Collidine
Synonyms
2,4,6-TRIMETHYLPYRIDINE;S-COLLIDINE;g-Collidine;2,4,6-Kollidin;246CO;2,4,6-CoL;SYM COLLIDINE;2,4,6-COLLIDINE;GAMMA-COLLIDINE;a,g,a'-Collidine
CBNumber:
CB6852760
Molecular Formula:
C8H11N
Molecular Weight:
121.18
MDL Number:
MFCD00006338
MOL File:
108-75-8.mol
MSDS File:
SDS
Last updated:2023-12-22 14:15:20

2,4,6-Collidine Properties

Melting point -43 °C (lit.)
Boiling point 171-172 °C (lit.)
Density 0.917 g/mL at 25 °C (lit.)
vapor pressure 4 hPa (20 °C)
refractive index n20/D 1.498(lit.)
Flash point 135 °F
storage temp. Store below +30°C.
solubility 35g/l
pka 7.43(at 25℃)
form Liquid
color Clear colorless to yellow
Water Solubility 35 g/L (20 ºC)
Sensitive Hygroscopic
Merck 14,9718
BRN 107283
Dielectric constant 1.9(20℃)
Stability Stable. Combustible. Incompatible with strong oxidizing agents.
LogP 1.25 at 20℃
Indirect Additives used in Food Contact Substances 2,4,6-TRIMETHYLPYRIDINE
CAS DataBase Reference 108-75-8(CAS DataBase Reference)
FDA UNII 7IE4BK5J5V
NIST Chemistry Reference Pyridine, 2,4,6-trimethyl-(108-75-8)
EPA Substance Registry System 2,4,6-Trimethylpyridine (108-75-8)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS02,GHS06
Signal word  Danger
Hazard statements  H226-H302+H332-H311-H315-H319-H335
Precautionary statements  P210-P280-P301+P312-P303+P361+P353-P304+P340+P312-P305+P351+P338
Hazard Codes  Xn
Risk Statements  10-20/21/22-36/37/38
Safety Statements  26-36/37-36
RIDADR  UN 1992 3/PG 3
WGK Germany  3
RTECS  UU0970000
TSCA  Yes
HazardClass  3
PackingGroup  III
HS Code  29333999
Toxicity LD50 orally in Rabbit: 400 mg/kg
NFPA 704
2
2 0

2,4,6-Collidine price More Price(33)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.22267 2,4,6-Trimethylpyridine for synthesis 108-75-8 50mL $53 2024-03-01 Buy
Sigma-Aldrich 8.22267 2,4,6-Trimethylpyridine for synthesis 108-75-8 250ML $110 2024-03-01 Buy
Sigma-Aldrich 8.22267 2,4,6-Trimethylpyridine for synthesis 108-75-8 1L $429 2024-03-01 Buy
Sigma-Aldrich 142387 2,4,6-Trimethylpyridine ReagentPlus , 99% 108-75-8 5ml $29.2 2024-03-01 Buy
Sigma-Aldrich 142387 2,4,6-Trimethylpyridine ReagentPlus , 99% 108-75-8 1l $832 2024-03-01 Buy
Product number Packaging Price Buy
8.22267 50mL $53 Buy
8.22267 250ML $110 Buy
8.22267 1L $429 Buy
142387 5ml $29.2 Buy
142387 1l $832 Buy

2,4,6-Collidine Chemical Properties,Uses,Production

Chemical Properties

colourless liquid

Uses

2,4,6-Collidine is an reagent used for various synthetic preparations such as the synthesis of methylated pyridines by three-componet catalytic condensation of acetylene, acetone and ammonia.

Uses

2,4,6-Collidine is used as a tissue fixative for electron microscopy. It is useful in dehydrohalogenation reactions and acts as a solvent for the cleavage of hindered esters by anhydrous lithium iodide.

Definition

Methyl, ethyl, propyl, and trimethyl homologs of pyridine.

Synthesis Reference(s)

Journal of the American Chemical Society, 72, p. 4184, 1950 DOI: 10.1021/ja01165a097

General Description

2,4,6-Trimethylpyridine is a pyridine derivative. It has a pK of 7.4. The product can react with trifluoroiodomethane in cyclopentane solution to afford 1:1 complex. This complex was investigated by NMR (Nuclear Magnetic Resonance) spectroscopy. Collidine-buffered osmium tetroxide solutions have been prepared by adding osmium tetroxide solution to it. These solutions have been used as fixative for electron microscopic studies.
2,4,6-Trimethylpyridine can undergo oxidation with potassium permanganate to form 2,4,6-pyridinetricarboxylic acid.

Hazard

Toxic.

Flammability and Explosibility

Flammable

Purification Methods

Commercial samples may be grossly impure. Likely contaminants include 3,5-dimethylpyridine, 2,3,6-trimethylpyridine and water. Brown, Johnson and Podall [J Am Chem Soc 76 5556 1954] fractionally distilled 2,4,6-trimethylpyridine under reduced pressure through a 40cm Vigreux column (p 11) and added to 430mL of the distillate slowly, with cooling to 0o, 45g of BF3-diethyl etherate. The mixture was again distilled, and an equal volume of dry *benzene was added to the distillate. Dry HCl was passed into the solution, which was kept cold in an ice-bath, and the hydrochloride was filtered off. It was recrystallised from absolute EtOH (1.5mL/g) to m 286-287o[m 256o(sealed tube), also m 293-294o subliming slowly]. The free base was regenerated by treatment with aqueous NaOH, then extracted with *benzene, dried (MgSO4) and distilled under reduced pressure. Sisler et al. [J Am Chem Soc 75 446 1953] precipitated trimethylpyridine as its phosphate from a solution of the base in MeOH by adding 85% H3PO4, shaking and cooling. The free base was regenerated as above. Garrett and Smythe [J Chem Soc 763 1903] purified the trimethylpyridine via the HgCl2 complex. It is more soluble in cold than hot H2O [the solubility is 20.8% at 6o, 3.5% at 20o, 1.8% at 100o]. Alternatively, purify it by dissolving it in CHCl3, adding solid K2CO3 and Drierite, filtering and fractionally distilling through an 8in helix-packed column. The sulfate has m 205o, and the picrate (from hot H2O) has m 155-156o. [Frank & Meikle J Am Chem Soc 72 4184 1950, Beilstein 20 H 250, 20 I 87, 20 II 164, 20 III/IV 2810, 20/6 V 93.]

3376-50-9
108-75-8
Synthesis of 2,4,6-Collidine from 2,4,6-trimethylpyridine 1-oxide
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View Lastest Price from 2,4,6-Collidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,4,6-Collidine pictures 2023-12-25 2,4,6-Collidine
108-75-8
US $0.00 / kg 1kg 99% 1000000 Hebei Jingbo New Material Technology Co., Ltd
2,4,6-Trimethylpyridine pictures 2023-10-08 2,4,6-Trimethylpyridine
108-75-8
US $30.00 / L 1L 99% 20T Firsky International Trade (Wuhan) Co., Ltd
2,4,6-Trimethylpyridine pictures 2023-07-19 2,4,6-Trimethylpyridine
108-75-8
US $30.00 / KG 1KG 99% 30 Tons Wuhan wingroup Pharmaceutical Co., Ltd
  • 2,4,6-Collidine pictures
  • 2,4,6-Collidine
    108-75-8
  • US $0.00 / kg
  • 99%
  • Hebei Jingbo New Material Technology Co., Ltd
2,4,6-trimethyl-pyridin a,g,a'-Collidine alpha,gamma,alpha’-collidine alpha,gamma,alpha'-Collidine Pyridine,2,4,6-trimethyl- 2 Minus 2-3 Methyl pyridine 2,4,6-Trimethylpyridine puriss. p.a., >=99.0% (GC) 2,4,6-Trimethylpyridine ReagentPlus(R), 99% 2,4,6-Trimethylpyridine Vetec(TM) reagent grade, 98% TMP 2,4,6-Collidine sym-Collidine s-Collidine SYM COLLIDINE 246CO 2,4,6-COLLIDINE GAMMA-COLLIDINE 2,4,6-COLLIDINE, REAGENTPLUS, 99% #nsym.-Collidine 2,4,6-Collidine99% 2,4,6-Collidine 99% Trimethylpyridine, 2,4,6- 2,4,6-COLLIDIN pure 2,4,6-Collidine, sym-Collidine 1H-Tetrazole, 5-phenyl-, barium salt Barium 5-phenyl-2,3,4-triaza-1-azanidacyclopenta-2,4-diene 2,4,6-Trimethylpyridine ,99% 2,4,6-Collidine,99%,electron microscopy grade 2,4,6-Collidine,75%,tech. 2,4,6-Trimethylpyridine,2,4,6-Collidine, sym-Collidine 2,4,6-Trimethylpyrid 2,4,6-Collidine, Reagent 2,4,6-Collidine, 99% 100ML 2,4,6-Collidine, 99% 500ML 2,4,6-Collidine, electron microscopy grade, 99% 2,4,6-Collidine, tech., 75% 2,6 -Dimethylpyridine (2,4,6-dimethylpyridine) 2,4,6-TRIMETHYLPYRIDINE(2,4,6-COLLIDINE) 2,4,6-COLLIDINE: 97.5% 2,4,6-COLLIDINE 2,4,6-TRIMETHYLPYRIDINE 2,4,6-Collidine 98+ % 2,4,6-Trimethylpyridine, 98.5% 2,4,6-CoL 2,4,6-Trimethylpyridine, 98.5%, for synthesis 2,4,6-Trimethylpyridine > 2,4,6-TRIMETHYLPYRIDINE FOR SYNTHESIS 2 minus 2 - butyl can force 2,4,6-Trimethylpyridinev Aqualine Electrolyte AD-G, for Karl Fischer analysis 2,4,6-Collidine pure, 98% 2,4,6-Kollidin g-Collidine S-COLLIDINE 2,4,6-TRIMETHYLPYRIDINE 108-75-8 Puriss p.a. General Use Analytical Reagents Analytical Chromatography Product Catalog Heterocyclic Compounds bc0001