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2,4,6-Collidine

2,4,6-Collidine
2,4,6-Collidine structure
CAS No.
108-75-8
Chemical Name:
2,4,6-Collidine
Synonyms
246CO;g-Collidine;S-COLLIDINE;SYM COLLIDINE;2,4,6-Kollidin;2,4,6-COLLIDINE;GAMMA-COLLIDINE;a,g,a'-Collidine;#nsym.-Collidine;2,4,6-Collidine99%
CBNumber:
CB6852760
Molecular Formula:
C8H11N
Formula Weight:
121.18
MOL File:
108-75-8.mol

2,4,6-Collidine Properties

Melting point:
−43 °C(lit.)
Boiling point:
171-172 °C(lit.)
Density 
0.917 g/mL at 25 °C(lit.)
vapor pressure 
4 hPa (20 °C)
refractive index 
n20/D 1.498(lit.)
Flash point:
135 °F
storage temp. 
2-8°C
solubility 
35g/l
form 
Liquid
pka
7.43(at 25℃)
color 
Clear colorless to yellow
Water Solubility 
35 g/L (20 ºC)
Sensitive 
Hygroscopic
Merck 
14,9718
BRN 
107283
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents.
CAS DataBase Reference
108-75-8(CAS DataBase Reference)
NIST Chemistry Reference
Pyridine, 2,4,6-trimethyl-(108-75-8)
EPA Substance Registry System
Pyridine, 2,4,6-trimethyl-(108-75-8)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS02,GHS06
Signal word  Danger
Hazard statements  H302-H226-H302+H332-H311-H315-H319-H335
Precautionary statements  P261-P280-P305+P351+P338-P312-P210-P303+P361+P353-P405-P501a
Hazard Codes  Xn
Risk Statements  10-20/21/22-36/37/38
Safety Statements  26-36/37-36
RIDADR  UN 1992 3/PG 3
WGK Germany  3
RTECS  UU0970000
TSCA  Yes
HazardClass  3
PackingGroup  III
HS Code  29333999
Toxicity LD50 orally in Rabbit: 400 mg/kg

2,4,6-Collidine price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 142387 2,4,6-Trimethylpyridine ReagentPlus , 99% 108-75-8 5ml $18.9 2018-11-13 Buy
Sigma-Aldrich 142387 2,4,6-Trimethylpyridine ReagentPlus , 99% 108-75-8 1l $417 2018-11-13 Buy
TCI Chemical T0716 2,4,6-Trimethylpyridine >98.0%(GC)(T) 108-75-8 25mL $22 2018-11-22 Buy
TCI Chemical T0716 2,4,6-Trimethylpyridine >98.0%(GC)(T) 108-75-8 100mL $65 2018-11-22 Buy
Alfa Aesar A11058 2,4,6-Collidine, 99% 108-75-8 25ml $22.6 2018-11-13 Buy

2,4,6-Collidine Chemical Properties,Uses,Production

Chemical Properties

colourless liquid

Uses

2,4,6-Collidine is an reagent used for various synthetic preparations such as the synthesis of methylated pyridines by three-componet catalytic condensation of acetylene, acetone and ammonia.

Definition

Methyl, ethyl, propyl, and trimethyl homologs of pyridine.

Hazard

Toxic.

Purification Methods

Commercial samples may be grossly impure. Likely contaminants include 3,5-dimethylpyridine, 2,3,6-trimethylpyridine and water. Brown, Johnson and Podall [J Am Chem Soc 76 5556 1954] fractionally distilled 2,4,6-trimethylpyridine under reduced pressure through a 40cm Vigreux column (p 11) and added to 430mL of the distillate slowly, with cooling to 0o, 45g of BF3-diethyl etherate. The mixture was again distilled, and an equal volume of dry *benzene was added to the distillate. Dry HCl was passed into the solution, which was kept cold in an ice-bath, and the hydrochloride was filtered off. It was recrystallised from absolute EtOH (1.5mL/g) to m 286-287o[m 256o(sealed tube), also m 293-294o subliming slowly]. The free base was regenerated by treatment with aqueous NaOH, then extracted with *benzene, dried (MgSO4) and distilled under reduced pressure. Sisler et al. [J Am Chem Soc 75 446 1953] precipitated trimethylpyridine as its phosphate from a solution of the base in MeOH by adding 85% H3PO4, shaking and cooling. The free base was regenerated as above. Garrett and Smythe [J Chem Soc 763 1903] purified the trimethylpyridine via the HgCl2 complex. It is more soluble in cold than hot H2O [the solubility is 20.8% at 6o, 3.5% at 20o, 1.8% at 100o]. Alternatively, purify it by dissolving it in CHCl3, adding solid K2CO3 and Drierite, filtering and fractionally distilling through an 8in helix-packed column. The sulfate has m 205o, and the picrate (from hot H2O) has m 155-156o. [Frank & Meikle J Am Chem Soc 72 4184 1950, Beilstein 20 H 250, 20 I 87, 20 II 164, 20 III/IV 2810, 20/6 V 93.]

2,4,6-Collidine Preparation Products And Raw materials

Raw materials

Preparation Products


2,4,6-Collidine Suppliers

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View Lastest Price from 2,4,6-Collidine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-07-11 2,4,6-Collidine
108-75-8
US $1.00 / KG 1KG 99% 25kg career henan chemical co
2019-05-23 2,4,6-Collidine
108-75-8
US $7.00 / KG 1KG 99% 1T career henan chemical co

2,4,6-Collidine Spectrum


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