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Trifluoroacetic anhydride

Trifluoroacetic anhydride
Trifluoroacetic anhydride structure
CAS No.
407-25-0
Chemical Name:
Trifluoroacetic anhydride
Synonyms
TFAA;trifluoroacetic;Trifluoroacetic anhy;uoroacetic anhydride;trimethylamine (TMA);TRIFLUOROACETO ANHYDRIDE;TIFLUOROACETIC ANHYDRIDE;RIFLUOROACETIC ANHYDRIDE;TRIFLUORACETIC ANHYDRIDE;perfluoroaceticanhydride
CBNumber:
CB6853606
Molecular Formula:
C4F6O3
Formula Weight:
210.03
MOL File:
407-25-0.mol

Trifluoroacetic anhydride Properties

Melting point:
-65 °C (lit.)
Boiling point:
39.5-40 °C (lit.)
Density 
1.511 g/mL at 20 °C (lit.)
vapor pressure 
6.28 psi ( 20 °C)
refractive index 
n20/D 1.3(lit.)
Flash point:
-26 °C
storage temp. 
2-8°C
solubility 
Miscible with benzene, dichloromethane, diethyl ether, dimethylformamide, terahydrofuran and acetonitrile.
form 
Liquid
Specific Gravity
1.487
color 
Clear
Water Solubility 
Hydrolysis
Sensitive 
Moisture Sensitive
BRN 
746197
Stability:
Stable, but moisture sensitive. Reacts with water to liberate hydrogen (flammable!). Incompatible with water, strong oxidizing agents.
CAS DataBase Reference
407-25-0(CAS DataBase Reference)
FDA UNII
5ENA87IZHT
NIST Chemistry Reference
Acetic acid, trifluoro-, anhydride(407-25-0)
EPA Substance Registry System
Acetic acid, trifluoro-, anhydride (407-25-0)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS05,GHS07
Signal word  Danger
Hazard statements  H318-H402-H314-H332-H412
Precautionary statements  P280-P305+P351+P338-P310-P273-P260h-P301+P330+P331-P303+P361+P353-P405-P501a
Hazard Codes  C,T
Risk Statements  14-20-35-52/53-34-23/24/25
Safety Statements  26-36/37/39-43-45-61-9-8-28A-27
RIDADR  UN 3265 8/PG 1
WGK Germany  2
RTECS  AJ9800000
3-10
Hazard Note  Corrosive/Moisture Sensitive
TSCA  T
HazardClass  8
PackingGroup  I
HS Code  29159080
Toxicity skn-rbt 500 mg/24H SEV 28ZPAK -,91,72
NFPA 704
0
3 1

Trifluoroacetic anhydride price More Price(27)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.08261 Trifluoroacetic anhydride for synthesis 407-25-0 25 mL $34.3 2021-03-22 Buy
Sigma-Aldrich 1.12513 Trifluoroacetic anhydride for gas chromatography 407-25-0 10 mL $120.25 2021-03-22 Buy
Sigma-Aldrich 8.08261 Trifluoroacetic anhydride for synthesis 407-25-0 100 mL $90.7 2021-03-22 Buy
Sigma-Aldrich 106232 Trifluoroacetic anhydride ReagentPlus , ≥99% 407-25-0 10x1g $199 2021-03-22 Buy
Sigma-Aldrich 8.08261 Trifluoroacetic anhydride for synthesis 407-25-0 500 mL $363 2021-03-22 Buy

Trifluoroacetic anhydride Chemical Properties,Uses,Production

Chemical Properties

Clear, colorless liquid

Uses

Used as analytical reagents, solvents, catalysts, dehydration condensing agent, protection agent of trifluoroacetylation of carboxyl and amino; used as Intermediate of fluorine fine chemicals, pharmaceutical, agrochemical.

Safety Profile

A severe skin and eye irritant.Explosive reaction with dimethyl sulfoxide; nitric acid +1,3,5-triazine (at 36°C); nitric acid + 1,3,5-triacetylhexahydro-1,3,5-triazine (at 30°C). Incompatiblewith lithium tetrahydroaluminate. When heated todecomposit

Purification Methods

Purification by distilling over KMnO4, as for the acid above, is EXTREMELY DANGEROUS due to the possiblility of EXPLOSION. It is best purified by distilling from P2O5 slowly, and collecting the fraction boiling at 39.5o. Store it in a dry atmosphere. Highly TOXIC vapour and attacks skin, work in an efficient fume hood. [Beilstein 2 IV 469.]

Trifluoroacetic anhydride Preparation Products And Raw materials

Raw materials

Preparation Products

1-[4-(TRIFLUOROMETHYL)PYRIMID-2-YL]PIPERAZINE 2-CYANO-4-PYRIDINE CARBOXYLIC ACID 2-Hydroxy-4-(trifluoromethyl)pyrimidine 2-Hydroxymethyl-5-bromopyridine 2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carbonitrile 2-Chloro-4-(trifluoromethyl)pyrimidine [BIS(TRIFLUOROACETOXY)IODO]PENTAFLUOROBENZENE 6-Aminobenzothiazole 2-HYDROXY-6-(TRIFLUOROMETHYL)NICOTINIC ACID 2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide (2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidin-4-yl)methanamine 2,6-DICHLORO-4-ISOCYANATOPYRIDINE Ethyl 2-(4-hydroxypiperidin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate Ethyl 2-(4-(ethoxycarbonyl)piperidin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate Ethyl 2-(4-(hydroxymethyl)piperidin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate 3-(Trifluoromethyl)pyrazole 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE Chlorfenapyr (2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidin-4-yl)methanol 3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine 4-CHLORO-ALPHA-[METHYL(TRIFLUOROACETYL)AMINO]-BENZENEACETIC ACID 2-(METHYLTHIO)-4-(TRIFLUOROMETHYL)PYRIMIDINE tert-Butyl 4-[4-(trifluoromethyl)pyrimidin-2-yl]piperazine-1-carboxylate ,97% 3-Nitroisonicotinic acid Ethyl 2-(4-methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride 5-Iodo-2,4-dimethoxypyrimidine N10-(TRIFLUOROACETYL)PTEROIC ACID 3-Amino-4-nitrobenzitrifluoride 2-(TRIFLUOROACETYL)THIOPHENE 2-BROMO-4-(TRIFLUOROMETHYL)PYRIMIDINE 2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carbaldehyde Epirubicin 2-(Bromomethyl)-6-methylpyridine 5-Bromopyridine-2-carbaldehyde ETHYL 5-AMINO-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE 2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylic acid 2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidin-4-amine 3-CHLORO-5-NITROPYRIDINE [Bis(trifluoroacetoxy)iodo]benzene

Trifluoroacetic anhydride Suppliers

Global( 404)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
CD Chemical Group Limited
+8613651442114
0086-13651442114 info@codchem.com China 20384 58
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20012 60
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 20903 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Shanghai Time Chemicals CO., Ltd.
+8618017249410 +86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com CHINA 1365 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8909 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55
Zjartschem
+86-571-8723 8903 jocelynpan@zjarts.com
+86-571-87063838 jocelynpan@zjarts.com CHINA 997 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
+86 0531-67809011 sales@sdzschem.com CHINA 2941 58

Related articles


View Lastest Price from Trifluoroacetic anhydride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-12-01 Trifluoroacetic Anhydride
407-25-0
US $10.00 / KG 1KG 99.7% 10 ton Hebei Crovell Biotech Co Ltd
2021-08-18 Trifluoroacetic acid anhydride
407-25-0
US $1.00 / g 1g 99% 100tons Hebei Binshare New Material Co. Ltd
2021-07-13 Trifluoroacetic anhydride
407-25-0
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

Trifluoroacetic anhydride Spectrum


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