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Procaine hydrochloride

CAS No.
51-05-8
Chemical Name:
Procaine hydrochloride
Synonyms
PROCAINE HCL;NOVOCAINE HYDROCHLORIDE;PROCAIN HYDROCHLORIDE;anestil;juvocaine;bernocaine;diethylaminoethanol4-aminobenzoatehydrochloride;cetain;naucaine;irocaine
CBNumber:
CB6853707
Molecular Formula:
C13H21ClN2O2
Molecular Weight:
272.77
MDL Number:
MFCD00007893
MOL File:
51-05-8.mol
MSDS File:
SDS
Last updated:2024-03-07 16:58:36

Procaine hydrochloride Properties

Melting point 155-156 °C(lit.)
Boiling point 195-196°C 17mm
Density 1.1761 (rough estimate)
refractive index 1.5270 (estimate)
Flash point 195-196°C/17mm
storage temp. 2-8°C
form Crystals or Crystalline Powder
color Colorless to white
Water Solubility soluble
Sensitive Air Sensitive
Merck 14,7757
BRN 3917802
Stability Stable. Incompatible with strong oxidizing agents.
InChIKey HCBIBCJNVBAKAB-UHFFFAOYSA-N
LogP 2.364 (est)
CAS DataBase Reference 51-05-8(CAS DataBase Reference)
FDA UNII 95URV01IDQ
EPA Substance Registry System Procaine hydrochloride (51-05-8)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301-H317
Precautionary statements  P261-P264-P270-P280-P301+P310-P302+P352
Hazard Codes  T
Risk Statements  25-43-36/37/38-23/24/25
Safety Statements  36/37/39-45-37/39-26
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  DG2275000
TSCA  Yes
HazardClass  6.1
PackingGroup  III
HS Code  29242990
Toxicity LD50 in mice (mg/kg): 660 ± 60 s.c. (Goldenthal)
NFPA 704
0
2 0

Procaine hydrochloride price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich P9879 Procaine hydrochloride ≥97% 51-05-8 50G $33 2024-03-01 Buy
Sigma-Aldrich P9879 Procaine hydrochloride ≥97% 51-05-8 100G $61.9 2024-03-01 Buy
Sigma-Aldrich PHR1161 Procaine hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material 51-05-8 1G $97.5 2024-03-01 Buy
Sigma-Aldrich P9879 Procaine hydrochloride ≥97% 51-05-8 250G $134 2024-03-01 Buy
Sigma-Aldrich P3100000 Procaine hydrochloride European Pharmacopoeia (EP) Reference Standard 51-05-8 P3100000 $158 2024-03-01 Buy
Product number Packaging Price Buy
P9879 50G $33 Buy
P9879 100G $61.9 Buy
PHR1161 1G $97.5 Buy
P9879 250G $134 Buy
P3100000 P3100000 $158 Buy

Procaine hydrochloride Chemical Properties,Uses,Production

Description

Procaine hydrochloride, also called Novocain, or Novocaine, a topical anesthetic, which can block the nerve fiber conduction temporarilyand has a narcotic effect,strong effect, low toxicity, and non-addictive, but on the skin, mucosal penetration is weak, unsuitable for surface anesthesia, patients are used for infiltration, conduction and spinal anesthesia.
The structure of procaine hydrochloride with aromatic primary amino, easy oxidation discoloration pH, temperature, UV, oxygen and metal ions can accelerate the oxidation discoloration. The aqueous solution was stable in pH3.0~5. So preparation of procaine hydrochloride injection, it generally takes add acid to regulate pH 3.3 to 5.5, and strictly control the sterilization temperature and time. to 100 ℃ steam sterilization 30min circulation is appropriate, and should pay attention to shading, sealed save.
The above information is edited by the chemicalbook of Kui Xiongfeng.

Chemical Properties

Procaine hydrochloride is a white crystalline, odorless powder that is freely soluble in water, but less soluble in alcohol and almost insoluble in ether; solutions acid to litmus. Because the ester bond in the structure can be hydrolyzed to produce p-aminobenzoic acid and diethylaminoethanol, under certain conditions, p-aminobenzoic acid can be further decarboxylated to produce toxic aniline. Procaine hydrochloride has aromatic primary amino groups in its structure, which can be easily oxidized and discolored. pH, temperature, ultraviolet light, oxygen and metal ions can accelerate the oxidation and discoloration.

Uses

Procaine is a local anesthetic of the amino ester group that is primarily used as a topical anesthetic. Procaine is also used to control the pain of intramuscular injection of penicillin as well as in dentistry.

Definition

ChEBI: Procaine hydrochloride is an organic molecular entity.

Application

Procaine hydrochloride has been used as a component of Krebs Henseleit buffer for incubating the left ventricular cardiac tissue in its resting length. It has also been used as an inducer in M9 media for induction assay. It is a sodium channel blocker and DNA methylation inhibitor.

brand name

Novocain (Hospira).

General Description

Procaine hydrochloride is a synthetic compound that belongs to the class of local anesthetic drugs. It has a structure similar to the natural compounds that participate in nerve impulse transmission. It shows interaction with the cellular membranes causing membrane lipids to expand, membrane-bound calcium to displace and change the structure of the proteins that are responsible for regulating the cell permeability and shape.

Hazard

Toxic by ingestion.

Contact allergens

Procaine is a local anesthetic with para-amino function. Sensitization mainly concerns the medical, dental, and veterinary professions.

Biochem/physiol Actions

Procaine is a Na+ channel blocker, commonly used as an anesthetic agent and is considered safer than cocaine. It is also useful as a painkiller to treat pain, associated with joints and tendons.

Safety Profile

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects: acute renal fdure. May have human reproductive effects. See also ESTERS. When heated to decomposition it emits very toxic fumes of HCl and NO,. Used as a local anesthetic.

Purification Methods

Novocain is recrystallised from aqueous EtOH. It is soluble at 25o in H2O (86.3%), EtOH (2.6%) and Me2CO (1%), it is slightly soluble in CHCl3, but is almost insoluble in Et2O. The anhydrous free base is recrystallised from ligroin or Et2O and has m 61o. [Einhorn Justus Liebigs Ann Chem 371 125 1909, IR: Szymanski & Panzica J Amer Pharm Assoc 47 443 1958, Beilstein 14 IV 1138.]

Mode of action

Procaine Hydrochloride is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodium channels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. In addition, this agent increases electrical excitation threshold, reduces rate of rise of action potential and slows nerve impulse propagation thereby causing loss of sensation.

Precautions

Procaine hydrochloride is used for infiltration, nerve block, peridural and spinal anest sthesia. It is considered a fairly safe drug if suitable precautions are observed. However, as with any anesthetic, idiosyncrasy may be encountered. Slow administration and avoidance of accidental intravenous injection are advisable. In local administration, if increased sensitivity to procaine is suspected, as in patients with cardiac disease or endocrine disorders (such as hyperthyroidism), an initial small dose to test tolerance is recommended. (Physicians' Desk Reference, 35th ed, p. 695)

Procaine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 552)Suppliers
Supplier Tel Email Country ProdList Advantage
Hefei TNJ Chemical Industry Co.,Ltd.
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View Lastest Price from Procaine hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Procaine hydrochloride pictures 2024-03-19 Procaine hydrochloride
51-05-8
US $110.00 / KG 1KG 99% 6000KG Shandong Luning Pharmaceutical Co., Ltd.
Procaine hydrochloride pictures 2024-03-19 Procaine hydrochloride
51-05-8
US $190.00 / KG 1KG 99% 6000KG Shandong Luning Pharmaceutical Co., Ltd.
Procaine hydrochloride pictures 2024-03-19 Procaine hydrochloride
51-05-8
US $0.00-0.00 / kg 1kg 99% 500 Wuhan Haorong Biotechnology Co.,Ltd
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