ChemicalBook
Chinese Japanese Germany Korea

Procaine hydrochloride

Local anesthetic
Procaine hydrochloride
Procaine hydrochloride structure
CAS No.
51-05-8
Chemical Name:
Procaine hydrochloride
Synonyms
cetain;anestil;irocaine;eugerase;naucaine;paracain;syncaine;topokain;anadolor;juvocaine
CBNumber:
CB6853707
Molecular Formula:
C13H21ClN2O2
Formula Weight:
272.77
MOL File:
51-05-8.mol

Procaine hydrochloride Properties

Melting point:
155-156 °C(lit.)
Boiling point:
195-196°C 17mm
Density 
1.1761 (rough estimate)
refractive index 
1.5270 (estimate)
Flash point:
195-196°C/17mm
storage temp. 
2-8°C
solubility 
Solution S is clear (2.2.1) and colourless (2.2.2, Method II).
form 
Crystals or Crystalline Powder
color 
Colorless to white
Water Solubility 
soluble
Sensitive 
Air Sensitive
Merck 
14,7757
BRN 
3917802
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
HCBIBCJNVBAKAB-UHFFFAOYSA-N
CAS DataBase Reference
51-05-8(CAS DataBase Reference)
FDA UNII
95URV01IDQ
EPA Substance Registry System
Procaine hydrochloride (51-05-8)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS06,GHS07
Signal word  Danger
Hazard statements  H301-H315-H319
Precautionary statements  P301+P310a-P321-P501a-P264-P270-P280-P301+P310+P330-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P405-P501
Hazard Codes  T
Risk Statements  25-43-36/37/38-23/24/25
Safety Statements  36/37/39-45-37/39-26
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  DG2275000
TSCA  Yes
HazardClass  6.1
PackingGroup  III
HS Code  29242990
Toxicity LD50 in mice (mg/kg): 660 ± 60 s.c. (Goldenthal)
NFPA 704
0
2 0

Procaine hydrochloride price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1564006 Procaine hydrochloride United States Pharmacopeia (USP) Reference Standard 51-05-8 200 mg $366 2021-03-22 Buy
TCI Chemical A1163 Procaine Hydrochloride >98.0%(HPLC)(T) 51-05-8 25g $18 2021-03-22 Buy
TCI Chemical A1163 Procaine Hydrochloride >98.0%(HPLC)(T) 51-05-8 100g $48 2021-03-22 Buy
Alfa Aesar A17485 2-Diethylaminoethyl 4-aminobenzoate hydrochloride, 99% 51-05-8 50g $27.3 2021-03-22 Buy
Alfa Aesar A17485 2-Diethylaminoethyl 4-aminobenzoate hydrochloride, 99% 51-05-8 250g $91.7 2021-03-22 Buy

Procaine hydrochloride Chemical Properties,Uses,Production

Local anesthetic

Procaine hydrochloride is a topical anesthetic, which can block the nerve fiber conduction temporarilyand has a narcotic effect,strong effect, low toxicity, and non-addictive, but on the skin, mucosal penetration is weak, unsuitable for surface anesthesia, patients are used for infiltration, conduction and spinal anesthesia.
White fine needle crystal or crystalline powder at room temperature, no smell, taste slightly bitter and Ma, soluble in water, soluble in ethanol, slightly soluble in chloroform, almost insoluble in ether. Procaine hydrochloride ester bond structure can be hydrolyzed to produce amino acid and diethylaminoethanol, under certain conditions, the amino acid may be further decarboxylated toxic aniline.
The structure of procaine hydrochloride with aromatic primary amino, easy oxidation discoloration pH, temperature, UV, oxygen and metal ions can accelerate the oxidation discoloration. The aqueous solution was stable in pH3.0~5. So preparation of procaine hydrochloride injection, it generally takes add acid to regulate pH 3.3 to 5.5, and strictly control the sterilization temperature and time. to 100 ℃ steam sterilization 30min circulation is appropriate, and should pay attention to shading, sealed save.
The product structure of aromatic primary amino group in dilute hydrochloric acid can generate diazonium salt with sodium nitrite, coupling reaction occurs when add alkaline β-naphthol, generating azo compounds scarlet.
The above information is edited by the chemicalbook of Kui Xiongfeng.

Chemical Properties

Small, colorless crystals or white, crys- talline powder; odorless; stable in air. Soluble in water and in alcohol at 25C; slightly soluble in chloroform; almost insoluble in ether; solutions acid to litmus.

Uses

Local anesthesic;Na+ channel blocker

Uses

Procaine is a local anesthetic of the amino ester group that is primarily used as a topical anesthetic. Procaine is also used to control the pain of intramuscular injection of penicillin as well as in dentistry.

Uses

Non Caine local anesthetic.

Uses

A sodium channel blocker and DNA methylation inhibitor

Uses

Procaine hydrochloride is a local anesthetic agent.

brand name

Novocain (Hospira).

Hazard

Toxic by ingestion.

Contact allergens

Procaine is a local anesthetic with para-amino function. Sensitization mainly concerns the medical, dental, and veterinary professions.

Safety Profile

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects: acute renal fdure. May have human reproductive effects. See also ESTERS. When heated to decomposition it emits very toxic fumes of HCl and NO,. Used as a local anesthetic.

Purification Methods

Novocain is recrystallised from aqueous EtOH. It is soluble at 25o in H2O (86.3%), EtOH (2.6%) and Me2CO (1%), it is slightly soluble in CHCl3, but is almost insoluble in Et2O. The anhydrous free base is recrystallised from ligroin or Et2O and has m 61o. [Einhorn Justus Liebigs Ann Chem 371 125 1909, IR: Szymanski & Panzica J Amer Pharm Assoc 47 443 1958, Beilstein 14 IV 1138.]

Procaine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products


Procaine hydrochloride Suppliers

Global( 387)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
15327141851 027-81302090
027-81302088 2851686515@qq.com CHINA 280 58
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55
Shanghai Worldyang Chemical Co.,Ltd.
+86-13651600618
CHINA 832 58
Jinan Jianfeng Chemical Co., Ltd
15562555968
0531-88113608 info@pharmachemm.com CHINA 200 58
Shijiazhuang Suking Biotechnology Co .,Ltd.
19955145978
19955145978 sales2@sxbiology.com CHINA 300 58
Xingtai Haoxun Import and Export Trade Co., Ltd.
+8617733977883 WhatsApp:+8617733976525
86-0319-5021664 lisa@xthaoxun.com CHINA 270 58
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
15377521700 +8615377521700
027-81302088 wangwendy93@gmail.com CHINA 869 58
Hebei Lihe Biotechnology Co.,ltd
13315122300 86-311-80292533
sales@lihebiotech.com CHINA 309 58
Hebei Lvyang Biotechnology Co.,Ltd
15030198922 +86 15030198922
0311-68052281 manager@ly-biotech.com CHINA 86 58
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 497 55

Related articles


View Lastest Price from Procaine hydrochloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-11-26 Procaine hydrochloride
51-05-8
US $30.00 / KG 1KG 99.9% 1000kg/month Shanxi Lianxu New Material Co., LTD
2021-11-26 procaine hydrochloride
?51-05-8
US $130.00 / KG 10g 99%min 200 kilogram Xingtai Haoxun Import and Export Trade Co., Ltd.
2021-11-26 Procaine hydrochloride
51-05-8
US $1.00 / KG 1KG 99% 10tons Xingtai Haoxun Import and Export Trade Co., Ltd.

Procaine hydrochloride Spectrum


51-05-8(Procaine hydrochloride)Related Search:


Copyright 2017 © ChemicalBook. All rights reserved