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Procaine hydrochloride

Local anesthetic
Procaine hydrochloride
Procaine hydrochloride
CAS No.
51-05-8
Chemical Name:
Procaine hydrochloride
Synonyms
cetain;anestil;anadolor;eugerase;irocaine;naucaine;paracain;syncaine;topokain;ethocaine
CBNumber:
CB6853707
Molecular Formula:
C13H21ClN2O2
Formula Weight:
272.77
MOL File:
51-05-8.mol

Procaine hydrochloride Properties

Melting point:
155-156 °C(lit.)
Boiling point:
195-196°C 17mm
Density 
1.1761 (rough estimate)
refractive index 
1.5270 (estimate)
Flash point:
195-196°C/17mm
storage temp. 
room temp
form 
Crystals or Crystalline Powder
color 
Colorless to white
Water Solubility 
soluble
Sensitive 
Air Sensitive
Merck 
14,7757
Stability:
Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference
51-05-8(CAS DataBase Reference)
EPA Substance Registry System
Benzoic acid, 4-amino-, 2-(diethylamino)ethyl ester, monohydrochloride(51-05-8)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T
Risk Statements  25-43-36/37/38-23/24/25
Safety Statements  36/37/39-45-37/39-26
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  DG2275000
TSCA  Yes
HazardClass  6.1
PackingGroup  III
Toxicity LD50 in mice (mg/kg): 660 ± 60 s.c. (Goldenthal)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P321 Specific treatment (see … on this label).
P405 Store locked up.
P501 Dispose of contents/container to..…

Procaine hydrochloride price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical A1163 Procaine Hydrochloride >98.0%(HPLC)(T) 51-05-8 25g $15 2017-11-08 Buy
TCI Chemical A1163 Procaine Hydrochloride >98.0%(HPLC)(T) 51-05-8 100g $53 2017-11-08 Buy
Alfa Aesar A17485 2-Diethylaminoethyl 4-aminobenzoate hydrochloride, 99% 51-05-8 250g $182 2017-11-08 Buy
Alfa Aesar A17485 2-Diethylaminoethyl 4-aminobenzoate hydrochloride, 99% 51-05-8 50g $45.4 2017-11-08 Buy

Procaine hydrochloride Chemical Properties,Uses,Production

Local anesthetic

Procaine hydrochloride is a topical anesthetic, which can block the nerve fiber conduction temporarilyand has a narcotic effect,strong effect, low toxicity, and non-addictive, but on the skin, mucosal penetration is weak, unsuitable for surface anesthesia, patients are used for infiltration, conduction and spinal anesthesia.
White fine needle crystal or crystalline powder at room temperature, no smell, taste slightly bitter and Ma, soluble in water, soluble in ethanol, slightly soluble in chloroform, almost insoluble in ether. Procaine hydrochloride ester bond structure can be hydrolyzed to produce amino acid and diethylaminoethanol, under certain conditions, the amino acid may be further decarboxylated toxic aniline.
The structure of procaine hydrochloride with aromatic primary amino, easy oxidation discoloration pH, temperature, UV, oxygen and metal ions can accelerate the oxidation discoloration. The aqueous solution was stable in pH3.0~5. So preparation of procaine hydrochloride injection, it generally takes add acid to regulate pH 3.3 to 5.5, and strictly control the sterilization temperature and time. to 100 ℃ steam sterilization 30min circulation is appropriate, and should pay attention to shading, sealed save.
The product structure of aromatic primary amino group in dilute hydrochloric acid can generate diazonium salt with sodium nitrite, coupling reaction occurs when add alkaline β-naphthol, generating azo compounds scarlet.
The above information is edited by the chemicalbook of Kui Xiongfeng.

Chemical Properties

white crystalline powder

Uses

Local anesthesic;Na+ channel blocker

Uses

Procaine is a local anesthetic of the amino ester group that is primarily used as a topical anesthetic. Procaine is also used to control the pain of intramuscular injection of penicillin as well as in dentistry.

Uses

Non Caine local anesthetic.

Uses

A sodium channel blocker and DNA methylation inhibitor

Contact allergens

Procaine is a local anesthetic with para-amino function. Sensitization mainly concerns the medical, dental, and veterinary professions.

Purification Methods

Novocain is recrystallised from aqueous EtOH. It is soluble at 25o in H2O (86.3%), EtOH (2.6%) and Me2CO (1%), it is slightly soluble in CHCl3, but is almost insoluble in Et2O. The anhydrous free base is recrystallised from ligroin or Et2O and has m 61o. [Einhorn Justus Liebigs Ann Chem 371 125 1909, IR: Szymanski & Panzica J Amer Pharm Assoc 47 443 1958, Beilstein 14 IV 1138.]

Procaine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products


Procaine hydrochloride Suppliers

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View Lastest Price from Procaine hydrochloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-09-19 Procaine hydrochloride
51-05-8
US $70.00 / KG 10G 99% 20 MT -
2018-03-08 Procaine
51-05-8
US $1000.00 / KG 10G 99.5% 100KG Hubei XinRunde Chemical Co., Ltd
2018-03-14 Procaine 200-077-2
51-05-8
US $1.00 / KG 1G 99% 100KG Hubei XinRunde Chemical Co., Ltd

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