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Benzamide

Benzamide
Benzamide structure
CAS No.
55-21-0
Chemical Name:
Benzamide
Synonyms
Benzamid;NSC 3114;ai3-01031;BENZAMIDE;Carbonamide;BENZOYLAMIDE;BENZOIC AMIDE;Benzamide,99%;Benzamide >BENZAMIDE 98+%
CBNumber:
CB6853808
Molecular Formula:
C7H7NO
Formula Weight:
121.14
MOL File:
55-21-0.mol

Benzamide Properties

Melting point:
125-128 °C (lit.)
Boiling point:
228°C
Density 
1.341
vapor pressure 
0.000056 hPa (20 °C)
refractive index 
1.5323 (estimate)
Flash point:
180°C
storage temp. 
Store below +30°C.
solubility 
ethanol: soluble50mg/mL, clear to very slightly hazy, colorless to light yellow
form 
Crystalline Powder
pka
13.0(at 25℃)
color 
White to almost white
PH
6.9 (H2O)(saturated solution)
PH Range
6.9
Water Solubility 
1.35 g/100 mL (20 ºC)
Merck 
14,1060
BRN 
385876
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents.
CAS DataBase Reference
55-21-0(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
6X80438640
NIST Chemistry Reference
Benzamide(55-21-0)
EPA Substance Registry System
Benzamide (55-21-0)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS08,GHS07
Signal word  Warning
Hazard statements  H302-H341
Precautionary statements  P264-P270-P301+P312+P330-P501-P201-P280-P301+P312a-P308+P313-P405-P501a-P281
Hazard Codes  Xn
Risk Statements  22-68
Safety Statements  22-24/25-36/37
WGK Germany  1
RTECS  CU8700000
Autoignition Temperature >500 °C
TSCA  Yes
HS Code  29242995
Toxicity LD50 orally in Rabbit: 1125 mg/kg
NFPA 704
1
2 0

Benzamide price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 135828 Benzamide 99% 55-21-0 5g $27 2021-03-22 Buy
Sigma-Aldrich 8.02191 Benzamide for synthesis 55-21-0 5 g $31.63 2021-03-22 Buy
Sigma-Aldrich 135828 Benzamide 99% 55-21-0 100g $44.1 2021-03-22 Buy
Sigma-Aldrich 8.02191 Benzamide for synthesis 55-21-0 250 g $63.36 2021-03-22 Buy
Sigma-Aldrich 8.02191 Benzamide for synthesis 55-21-0 25 kg $934.25 2021-03-22 Buy

Benzamide Chemical Properties,Uses,Production

Description

Benzamide appears as off-white crystals or powder. It is combustible and incompatible with strong oxidising agents and strong bases. On combustion and thermal decomposition, it emits nitrogen oxides, carbon monoxide, and carbon dioxide.
Benzamide is a carbonic acid amide of benzoic acid. Benzamide exhibits an angle of about 15º with the plane of the amide group; this shows that benzamide molecule is not flat. The rotation of the amide group relative to the aromatic ring may result from the repulsion interaction between the hydrogen atoms of the amide group and those of the aromatic ring.

Chemical Properties

Benzamide is a combustible, colorless to beige, off-white, crystalline solid; freezing/melting point=132-133° C. It is slightly soluble in water, and soluble in many organic solvents.
Benzamide
Benzamide was used to study the mechanism of photocatalytic decomposition of aqueous solution of acetic acid, acetamide and acetonitrile in the presence of semiconductors. It was used to develop a robust screening method to study biotransformations using (+)-γ-lactamase enzyme.

Uses

Organic synthesis.

Preparation

Take a mixture of 5 ml concentrated ammonia and 5 ml water in a conical flask with a well-fitting cork. Add 2 ml (2.4 g.) benzoyl chloride, cork the flask and shake vigorously. Heat generates due to the reaction, hence hold the cork securely during shaking. After 15 min not even a trace of oily benzoyl chloride remains. Filter the fine flakes, wash with cold water and recrystallise from hot water: yield, 1-5 g. Colourless crystals of benzamide.
Preparation of benzamide from benzoyl chloride
Preparation of benzamide from benzoyl chloride

Definition

ChEBI: An aromatic amide that consists of benzene bearing a single carboxamido substituent. The parent of the class of benzamides.

Synthesis Reference(s)

The Journal of Organic Chemistry, 59, p. 4114, 1994 DOI: 10.1021/jo00094a021
Chemical and Pharmaceutical Bulletin, 39, p. 1152, 1991 DOI: 10.1248/cpb.39.1152
Synthetic Communications, 20, p. 1445, 1990 DOI: 10.1080/00397919008052860

General Description

White powder.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Benzamide reacts with azo and diazo compounds to generate toxic gases. Forms flammable gases with strong reducing agents. Mixing with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. Combustion generates toxic mixed oxides of nitrogen (NOx).

Hazard

Depresses the central nervous system; toxic.

Fire Hazard

Flash point data for Benzamide are not available, however Benzamide is probably combustible.

Clinical Use

Benzamide on radioiodination by different labeling procedures results in large-scale production of radioiodinated benzamides having potential therapeutic application for patients with metastatic malignant melanoma.

Potential Exposure

Benzamide is used in organic synthesis.

Purification Methods

Crystallise it from hot water (about 5mL/g), EtOH or 1,2-dichloroethane, and dry it in air. It has also been crystallised from dilute aqueous NH3, H2O, Me2CO, then *C6H6 using a Soxhlet extractor. Dry it in an oven at 110o for 8hours and store in a desiccator over 99% H2SO4. [Bates & Hobbs J Am Chem Soc 73 2151 1951, Beilstein 9 IV 725.]

Benzamide Preparation Products And Raw materials

Raw materials

Preparation Products


Benzamide Suppliers

Global( 297)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 3001 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29961 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Accela ChemBio Inc.
(+1)-858-699-3322
(+1)-858-876-1948 info@accelachem.com United States 19969 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5450 58
Shaanxi Pioneer Biotech Co., Ltd .
86-13259417953(Whatsapp/Wechat) 86-13259417953(Whatsapp)
029-84385017 sales@pioneerbiotech.com CHINA 3001 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23035 58
Changzhou Carman Chemical Co., Ltd.
15061933924
jane@carmanchem.com; catal@carmanchem.com CHINA 514 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63726 58

View Lastest Price from Benzamide manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-07-13 Benzamide
55-21-0
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
2021-07-10 Benzamide
55-21-0
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
2021-04-07 Benzamide
55-21-0
US $10.00 / PCS 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.

Benzamide Spectrum


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