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Epothilone A

Epothilone A
Epothilone A structure
CAS No.
152044-53-6
Chemical Name:
Epothilone A
Synonyms
Epothile;Epothilone-S;EPOTHILONE A;Ixabepilone Impurity 5;Ixabepilone Impurity 5 (Epothilone A);4,17-Dioxabicyclo[14.1.0]heptadecane-5,9-dione,7,11-dihydroxy-8,8,10,12-tetraMethyl-3- [(1E)-1-Methy;(1S,3S,7S,10R,11S,12S,16R,E)-7,11-dihydroxy-8,8,10,12-tetramethyl-3-(1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxa-bicyclo[14.1.0]heptadecane-5,9-dione;4,17-Dioxabicyclo14.1.0heptadecane-5,9-dione, 7,11-dihydroxy-8,8,10,12-tetramethyl-3-(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl-, (1S,3S,7S,10R,11S,12S,16R)-;(1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12-tetramethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione;4,17-Dioxabicyclo[14.1.0]heptadecane-5,9-dione,7,11-dihydroxy-8,8,10,12-tetramethyl-3- [(1E)-1-methyl-2-(2-methyl-4-thiazolyl)- ethenyl]-,(1R,3R,7R,10S,11R,12R,16S)-rel-
CBNumber:
CB6972280
Molecular Formula:
C26H39NO6S
Formula Weight:
0
MOL File:
152044-53-6.mol

Epothilone A Properties

Melting point:
95℃
alpha 
D21 -47.1° (c = 1.0 in methanol)
Density 
1.143
storage temp. 
?20°C
form 
solid
SAFETY
  • Risk and Safety Statements
WGK Germany  3

Epothilone A price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich E3656 (?)-Epothilone A from 152044-53-6 10ug $197 2018-11-20 Buy
Cayman Chemical 16482 Epothilone A ≥95% 152044-53-6 1mg $35 2018-11-13 Buy
Cayman Chemical 16482 Epothilone A ≥95% 152044-53-6 5mg $96 2018-11-13 Buy
Cayman Chemical 16482 Epothilone A ≥95% 152044-53-6 10mg $175 2018-11-13 Buy

Epothilone A Chemical Properties,Uses,Production

Uses

The epothilones are a novel class of antineoplastic agents possessing antitubulin activity. Epothilone A, B isolated from Sorangium cellulosum was associated with cell cycle arrest at G2/M transition and apoptosis that was resisted with overexpression of β-tubulin and P-glycoprotein in human bladder carcinoma cell.

Uses

Epothilone A is a microtubule inhibitor isolated from the myxobacteria, Sorangium cellulosum. Epothilone A acts by stabilising microtubule formation at the taxol binding site, and causes cell cycle arrest at the G2/M transition, leading to cytotoxicity. Epothilone A has been investigated in clinical trials as an antitumour agent.

Uses

Epothilone A is a microtubule inhibitor isolated from the myxobacteria, Sorangium cellulosum. Epothilone A acts by stabilising microtubule formation at the taxol binding site, and causes cell cycle arrest at the G2/M transition, leading to cytotoxicity. Epothilone A has been investigated in clinical trials as an antitumor agent.

Definition

ChEBI: An epithilone that is epothilone C in which the double bond in the macrocyclic lactone ring has been oxidised to the corresponding epoxide (the 13R,14S diastereoisomer).

Epothilone A Preparation Products And Raw materials

Raw materials

Preparation Products


Epothilone A Suppliers

Global( 72)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30002 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 sales@jushengtech.com CHINA 28236 58
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8407 58
Standardpharm Co. Ltd.
0714-3992388
yxzy@std-med.net CHINA 13064 58
BOC Sciences
1-631-619-7922
1-631-614-7828 inquiry@bocsci.com United States 20115 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 35440 58
Shanghai Boyle Chemical Co., Ltd.
86-21-57758967 sales@boylechem.com China 2926 55
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Chembest Research Laboratories Limited +86(0)21-20908456
+86(0)21-58180499 sales@biochembest.com; market@biochembest.com China 5995 61
LGM Pharma 1-(800)-881-8210
615-250-9817 inquiries@lgmpharma.com United States 1940 70

View Lastest Price from Epothilone A manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-07-09 Epothilone A
152044-53-6
US $1.00 / KG 1KG 99% 100kg career henan chemical co

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