2-Hydroxychalcone
- CAS No.
- 644-78-0
- Chemical Name:
- 2-Hydroxychalcone
- Synonyms
- 2-HYDROXYCHALCONE;o-Hydroxychalcone;2-HYDROXYCHALCONE;HYDROXYCHALCONE, 2-;2-Hydroxychalcone>SALICYLALACETOPHENONE;2-Hydroxychalcone, 98+%;TRANS-2-HYDROXYCHALCONE;2-(2-HYDROXYBENZAL)ACETOPHENONE;2-HYDROXYBENZYLIDENE ACETOPHENONE
- CBNumber:
- CB7100356
- Molecular Formula:
- C15H12O2
- Molecular Weight:
- 224.25
- MDL Number:
- MFCD00016449
- MOL File:
- 644-78-0.mol
| Melting point | 144-150 °C(lit.) |
|---|---|
| Boiling point | 396.3±34.0 °C(Predicted) |
| Density | 1.191±0.06 g/cm3(Predicted) |
| pka | 9.26±0.35(Predicted) |
| form | powder |
| color | Yellow |
| BRN | 2049134 |
| CAS DataBase Reference | 644-78-0(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29147000 | |||||||||
| NFPA 704 |
|
2-Hydroxychalcone price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S218170 | 3-(2-HYDROXY-PHENYL)-1-PHENYL-PROPENONE AldrichCPR | 644-78-0 | 25MG | $29.8 | 2024-03-01 | Buy |
| TCI Chemical | H0234 | 2-Hydroxychalcone >98.0%(GC)(T) | 644-78-0 | 5g | $54 | 2021-12-16 | Buy |
| TCI Chemical | H0234 | 2-Hydroxychalcone >98.0%(GC)(T) | 644-78-0 | 25g | $148 | 2021-12-16 | Buy |
| Alfa Aesar | A12851 | 2-Hydroxychalcone, 98+% | 644-78-0 | 5g | $34.65 | 2024-03-01 | Buy |
| Alfa Aesar | A12851 | 2-Hydroxychalcone, 98+% | 644-78-0 | 25g | $126.65 | 2024-03-01 | Buy |
2-Hydroxychalcone Chemical Properties,Uses,Production
Description
2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. It is also capable of inducing apoptosis by downregulating Bcl-2 levels and inhibiting the activation of NF-kB.
Synthesis
A synthesis of 2-Hydroxychalcone was conducted using acetophenone and o-hydroxybenzaldehyde as starting materials. The reaction was catalyzed by potassium hydroxide and ethanol was used as the solvent.
in vitro
2-Hydroxychalcone inhibits invasion of triple negative breast cancer cells.
2-hydroxychalcone inhibits the adhesion of peripheral neutrophils to the endothelial cell monolayers by inhibiting the expression of ICAM-1, VCAM-1, and E-selectin in a concentration-dependent manner.
References
[1]. Sun Young Kim, et al. 2-Hydroxychalcone and Xanthohumol Inhibit Invasion of Triple Negative Breast Cancer Cells. Chem Biol Interact. 2013 May 25;203(3):565-72. DOI:10.1016/j.cbi.2013.03.012
[2]. B Madan, et al. 2'-hydroxychalcone Inhibits Nuclear factor-kappaB and Blocks Tumor Necrosis Factor-Alpha- And Lipopolysaccharide-Induced Adhesion of Neutrophils to Human Umbilical Vein Endothelial Cells. Mol Pharmacol. 2000 Sep;58(3):526-34. DOI:10.1124/MOL.58.3.526
[3]. Sonochemical Synthesis of 2’-Hydroxy-Chalcone Derivatives with Potential Anti-Oomycete Activity doi: 10.3390/antibiotics9090576
2-Hydroxychalcone Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12382 | 58 |
| GLR Innovations | +91 9891111994 | info@glrgroup.in | India | 4542 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49999 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
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