SR 31747
- CAS No.
- 132173-07-0
- Chemical Name:
- SR 31747
- Synonyms
- SR 31747;SR 31747,SR31747;HKHPCMBPASXYGP-KVVVOXFISA-N;(Z)-N-(3-(3-Chloro-4-cyclohexylphenyl)allyl)-N-ethylcyclohexanamine;3-(3-Chloro-4-cyclohexylphenyl)-N-cyclohexyl-N-ethyl-2(Z)-propenylaMine;(Z)-N-(3-(3-Chloro-4-cyclohexylphenyl)allyl)-N-ethylcyclohexanamine hydrochloride;3-(3-Chloro-4-cyclohexylphenyl)-N-cyclohexyl-N-ethyl-2(Z)-propenylaMine hydrochloride;(Z)-N-[3-(3-CHLORO-4-CYCLOHEXYLPHENYL)PROP-2-ENYL]-N-ETHYLCYCLOHEXYLAMINE HYDROCHLORIDE
- CBNumber:
- CB71011640
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- 132173-07-0.mol
| Product description | Number | Pack Size | Price |
| SR-31747 99.80% | CS-0007776 | 5mg | $350 |
| SR-31747 99.80% | CS-0007776 | 10mg | $550 |
| SR-31747 99.80% | CS-0007776 | 100mg | $2250 |
| More product size | |||
| form | Solid |
|---|---|
| color | White to off-white |
| FDA UNII | 9K6U3I1UR0 |
SR 31747 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0007776 | SR-31747 99.80% | 132173-07-0 | 5mg | $350 | 2021-12-16 | Buy |
| ChemScene | CS-0007776 | SR-31747 99.80% | 132173-07-0 | 10mg | $550 | 2021-12-16 | Buy |
| ChemScene | CS-0007776 | SR-31747 99.80% | 132173-07-0 | 100mg | $2250 | 2021-12-16 | Buy |
SR 31747 Chemical Properties,Uses,Production
Uses
SR-31747 is a sigma ligand with immunosuppressive and anti-inflammatory properties. SR-31747 blocks cell proliferation by inhibiting sterol isomerase[1][2].
in vivo
In vivo, SR-31747 dramatically blocks lipopolysaccharide-induced production of IL-1, IL-6 and TNF-α in a dose-dependent manner (ED50, 2 mg/kg). SR-31747 probably abrogated monokine production through an indirect mechanism that involves endogenous corticosteroids. This conclusion was supported by in vivo experiments that shows that: 1) ablation of corticosteroids by use of Mifepristone or adrenalectomy suppress the effect of SR-31747; 2) administration of SR-31747 induces an enhancement of the corticosterone level. SR-31747 improves the survival of animals with endotoxinic shock as a result of monokine inhibition[1].
References
[1] Derocq JM, et al. In vivo inhibition of endotoxin-induced pro-inflammatory cytokines production by the sigma ligand SR 31747. J Pharmacol Exp Ther. 1995 Jan;272(1):224-30. PMID:7815336
[2] Silve S, et al. The immunosuppressant SR 31747 blocks cell proliferation by inhibiting a steroid isomerase in Saccharomyces cerevisiae. Mol Cell Biol. 1996 Jun;16(6):2719-27. DOI:10.1128/MCB.16.6.2719
SR 31747 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32435 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33338 | 58 |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19962 | 58 |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| Shanghai hongqu biomedical technology co. LTD | 88888888888 | hongquchem@qq.com | China | 5132 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29757 | 58 |
| Beijing Stronger Science Co., Ltd. | 0531-88924771 15614660963 | elsa.hang@strongerscience.com | China | 10623 | 58 |
