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3-Aminopyrazine-2-carboxylic acid

3-Aminopyrazine-2-carboxylic acid structure

CAS No.: 5424-01-1

Chemical Name:: 3-Aminopyrazine-2-carboxylic acid

Synonyms: 3-AMINO-2-PYRAZINECARBOXYLIC ACID;NSC 13148;Deacetylhypnosin;TIMTEC-BB SBB004179;3-Aminopyrazine-2-ca;3-Aminopyrazinoic acid;2-Amino-3-pyrazinecarboxyL;3-Aminophrazine-2-carboxylic acid;3-AMINOPYRAZINE-2-CARBOXYLIC ACID;2-Aminopyrazine-3-carboxylic acid

CBNumber:: CB7103665

Molecular Formula:: C5H5N3O2

Molecular Weight:: 139.11

MDL Number:: MFCD00006141

MOL File:: 5424-01-1.mol

MSDS File:: SDS

Last updated:2026-01-13 11:24:02

Product description	Number	Pack Size	Price
3-Amino-2-pyrazinecarboxylic acid ≥99%	A76982	5g	$23.7
3-Amino-2-pyrazinecarboxylic acid ≥99%	A76982	25g	$42.8
3-Aminopyrazine-2-carboxylic Acid >98.0%(HPLC)(T)	A0848	5g	$55
3-Aminopyrazine-2-carboxylic Acid >98.0%(HPLC)(T)	A0848	25g	$163
3-Amino-2-pyrazinecarboxylic acid	A628925	100g	$160
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3-Aminopyrazine-2-carboxylic acid Properties

Melting point	205-210 °C (dec.) (lit.)
Boiling point	255.04°C (rough estimate)
Density	1.4551 (rough estimate)
refractive index	1.5900 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO (Sparingly) , Methanol (Slightly)
pka	3.65±0.10(Predicted)
form	Crystalline Powder
color	Yellow-greenish
BRN	124835
InChI	InChI=1S/C5H5N3O2/c6-4-3(5(9)10)7-1-2-8-4/h1-2H,(H2,6,8)(H,9,10)
InChIKey	ZAGZIOYVEIDDJA-UHFFFAOYSA-N
SMILES	C1(C(O)=O)=NC=CN=C1N
LogP	-3.1 at 20℃ and pH7
Surface tension	73.6mN/m at 1g/L and 20℃
CAS DataBase Reference	5424-01-1(CAS DataBase Reference)
FDA UNII	X78B5D12FN
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

Hazard Note

Irritant

HS Code

29339990

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Dam. 1

NFPA 704

	0
3		0

3-Aminopyrazine-2-carboxylic acid price More Price(28)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	A76982	3-Amino-2-pyrazinecarboxylic acid ≥99%	5424-01-1	5g	$23.7	2026-03-19	Buy
Sigma-Aldrich	A76982	3-Amino-2-pyrazinecarboxylic acid ≥99%	5424-01-1	25g	$42.8	2026-03-19	Buy
TCI Chemical	A0848	3-Aminopyrazine-2-carboxylic Acid >98.0%(HPLC)(T)	5424-01-1	5g	$55	2026-03-19	Buy
TCI Chemical	A0848	3-Aminopyrazine-2-carboxylic Acid >98.0%(HPLC)(T)	5424-01-1	25g	$163	2026-03-19	Buy
TRC	A628925	3-Amino-2-pyrazinecarboxylic acid	5424-01-1	100g	$160	2021-12-16	Buy

Product number	Packaging	Price	Buy
A76982	5g	$23.7	Buy
A76982	25g	$42.8	Buy
A0848	5g	$55	Buy
A0848	25g	$163	Buy
A628925	100g	$160	Buy

3-Aminopyrazine-2-carboxylic acid Chemical Properties,Uses,Production

Chemical Properties

Pale Brown Crystalline Solid

Uses

Antidiabetic

Synthesis

16298-03-6

5424-01-1

General procedure for the synthesis of 3-aminopyrazine-2-carboxylic acid from methyl 3-aminopyrazine-2-carboxylate: Methyl 3-aminopyrazine-2-carboxylate (2.08 g, 13.6 mmol) was suspended in methanol (40 mL) under nitrogen protection, and treated with 1N aqueous sodium hydroxide (30 mL). The reaction mixture was warmed up to room temperature and stirred for 50 min. Subsequently, methanol (about 45 mL) was partially evaporated under reduced pressure. The resulting mixture was cooled in an ice water bath and 1N aqueous hydrochloric acid solution (70 mL) was slowly added. Initially the mixture appeared as a solution and gradually a precipitate was generated with further addition of acid. The solid product was collected by filtration, washed with water (3 x 10 mL) and finally dried under vacuum to give 1.48 g of the target product 3-aminopyrazine-2-carboxylic acid.

References

[1] Journal of Medicinal Chemistry, 2011, vol. 54, # 7, p. 2320 - 2330
[2] Patent: WO2013/169907, 2013, A1. Location in patent: Page/Page column 44

3-Aminopyrazine-2-carboxylic acid Preparation Products And Raw materials

Raw materials

Methyl 3-amino-2-pyrazinecarboxylate Sodium hydroxide Methanol Water

Preparation Products

2-Amino-5-chloropyrazine methyl 3-bromopyrazine-2-carboxylate 3-AMINOPYRAZINE-2-CARBONITRILE methyl 3,6-dibromopyrazine-2-carboxylate 3-AMINO-N-METHYLPYRAZINE-2-CARBOXAMIDE

2-Pyrazinecarboxylic acid, 3-(acetylamino)-

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3-Aminopyrazine-2-carboxylic acid Suppliers

Global( 406)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ANHUI CHICO CHEMICAL CO., LTD.	+8613057662806	kirsten@chicopharm.com	China	2396	58
Hebei Yanxi Chemical Co., Ltd.	+8618531123677	faithe@yan-xi.com	China	5853	58
Wuhan Fortuna Chemical Co., Ltd	+86-27-59207850	info@fortunachem.com	China	5974	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-86-13131129325 +8613131129325	sales1@chuanghaibio.com	China	5235	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18126	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21591	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29820	58
NINGBO INNO PHARMCHEM CO., LTD.	13867897135	sales@nbinno.com	CHINA	923	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10404	58

Supplier	Advantage
ANHUI CHICO CHEMICAL CO., LTD.	58
Hebei Yanxi Chemical Co., Ltd.	58
Wuhan Fortuna Chemical Co., Ltd	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
NINGBO INNO PHARMCHEM CO., LTD.	58
Shenzhen Nexconn Pharmatechs Ltd	58

View Lastest Price from 3-Aminopyrazine-2-carboxylic acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-29	3-Aminopyrazine-2-carboxylic acid 5424-01-1	US $0.00-0.00 / Kg/Drum	1KG	98%min	500KGS	WUHAN FORTUNA CHEMICAL CO., LTD
2025-12-01	3-Aminopyrazine-2-carboxylic acid 5424-01-1	US $0.00 / kg	1kg	99%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2025-06-27	3-Aminopyrazine-2-carboxylic acid 5424-01-1	US $0.00-0.00 / KG	1KG	99%	500000kg	Hebei Chuanghai Biotechnology Co., Ltd

3-Aminopyrazine-2-carboxylic acid
5424-01-1
US $0.00-0.00 / Kg/Drum
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

3-Aminopyrazine-2-carboxylic acid
5424-01-1
US $0.00 / kg
99%
Shaanxi Dideu New Materials Co. Ltd

3-Aminopyrazine-2-carboxylic acid
5424-01-1
US $0.00-0.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

3-Aminopyrazine-2-carboxylic acid Spectrum

3-Aminopyrazine-2-carboxylic acid(5424-01-1)¹HNMR 3-Aminopyrazine-2-carboxylic acid(5424-01-1)FT-IR 3-Aminopyrazine-2-carboxylic acid(5424-01-1)Raman 3-Aminopyrazine-2-carboxylic acid(5424-01-1)IR

5424-01-1(3-Aminopyrazine-2-carboxylic acid)Related Search:

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3-AMINOPYRAZINE-2-CARBOXYLIC ACID METHYL ESTER 3-Aminopyrazole-4-carboxylic acid Pyrazinecarboxylic acid, 6-amino-, methyl ester (9CI) 2-Pyrazinecarboxylic acid Aminopyrazine

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TIMTEC-BB SBB004179 3-AMINOPYRAZINE-2-CARBOXYLIC ACID 3-AMINOPIPERAZINE-2-CARBOXYLIC ACID 7. 3-AMinopyrazine-2-carboxylic acid 3-Amino-2-pyrazinecarboxylic acid >=99% 3-Aminophrazine-2-carboxylic acid 3-AMINOPYRAZINE-2-CARBOXYLIC ACIDCRYSTAL LINE 3-AMINOPYRAZINE-2-CARBOXYLIC ACID, 99+% Pyrazinecarboxylic acid, 3-amino- (7CI,8CI,9CI) 3-Aminopyrazine-2-carboxylic acid 98% 3-AMINO-2-PYRAZINECARBOXYLIC ACID, TECHN. 97% 3-aMinopyrazine-2-carboxylic -CAS5424-01-1 2-Amino-3-carboxypyrazine, 2-Amino-3-carboxy-1,4-diazine 2-Aminopyrazine-3-carboxylic acid 3-Aminopyrazinoic acid 2-Amino-3-pyrazinecarboxylic Acid 2-Pyrazinecarboxylic acid, 3-amino- 3-Aminopyrazine-2-carboxylic acid ,98% 3-Aminopyrazine-2-ca 3-AMinopyrazine-2-carboxylic acid, 99+% 5GR NSC 13148 3-Aminopyrazine 2-Carboxyilic Acid 3-AMINOPYRAZINE-2-CARBOXYLIC ACID‘5424-01-1 2-Amino-3-pyrazinecarboxyL 3-Aminopyrazine-2-carboxylic Acid > 3-Aminopyrazine-2-carboxylic acid ISO 9001：2015 REACH 3-Aminopyrazine-2-carboxilic acid 3-AMINO-2-PYRAZINECARBOXYLIC ACID Deacetylhypnosin 5424-01-1 5242-01-1 1287-11-6 6424-01-0 5424-1-1 5421-01-1 C5H4N3O2 CARBOXYLIC ACID Building Blocks Pyrazines Pyrazinecarboxylic Acid & Derivatives Heterocyclic Building Blocks Pyrazinecarboxylic Acid & Derivatives Bases & Related Reagents Heterocycles Nucleotides Building Blocks Heterocyclic Building Blocks Heterocyclic Compounds pharmacetical AMINOACID Pyrazines amine | carboxylic acid bc0001