ACETYLENEDICARBOXAMIDE
- CAS No.
- 543-21-5
- Chemical Name:
- ACETYLENEDICARBOXAMIDE
- Synonyms
- Renamycin;Lenamycin;Aquamycin;4-Dioxane-2;2-BUTYNEDIAMIDE;but-2-ynediaMide;ACETYLENEDICARBOXAMIDE;1,2-Ethynedicarboxamide;Acetylendicarbonsaeureamid;acetylenedicarboxylicaciddiamide
- CBNumber:
- CB7103786
- Molecular Formula:
- C4H4N2O2
- Molecular Weight:
- 112.09
- MDL Number:
- MFCD00017146
- MOL File:
- 543-21-5.mol
| Melting point | 179 °C |
|---|---|
| Boiling point | 209.98°C (rough estimate) |
| Density | 1.4421 (rough estimate) |
| refractive index | 1.4610 (estimate) |
| storage temp. | Store at -20°C |
| solubility | DMF: 10 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2) (1:7): 0.12 mg/ml |
| form | Fine Crystalline Powder |
| pka | 13.01±0.50(Predicted) |
| color | Cream to beige |
| EWG's Food Scores | 1 |
| FDA UNII | 1K327HA41T |
| EPA Substance Registry System | 2-Butynediamide (543-21-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25-21 | |||||||||
| Safety Statements | 45-36/37-28A | |||||||||
| HS Code | 29241900 | |||||||||
| Toxicity | LD50 i.v. in mice: 11 mg/kg (Suzuki) | |||||||||
| NFPA 704 |
|
ACETYLENEDICARBOXAMIDE price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 23637 | Cellocidin ≥95% | 543-21-5 | 5mg | $97 | 2024-03-01 | Buy |
| Cayman Chemical | 23637 | Cellocidin ≥95% | 543-21-5 | 10mg | $156 | 2024-03-01 | Buy |
| Cayman Chemical | 23637 | Cellocidin ≥95% | 543-21-5 | 25mg | $340 | 2024-03-01 | Buy |
| Cayman Chemical | 23637 | Cellocidin ≥95% | 543-21-5 | 50mg | $631 | 2024-03-01 | Buy |
| TRC | C255953 | Cellocidin | 543-21-5 | 5mg | $305 | 2021-12-16 | Buy |
ACETYLENEDICARBOXAMIDE Chemical Properties,Uses,Production
Description
Cellocidin is an antibiotic originally isolated from S. chibaensis. It is active against various bacterial strains including M. tuberculosis and against the trypanosomes T. brucei and T. rhodesiense (IC50s = 150 and 30 ng/ml, respectively). It inhibits proliferation of LCL1 and LCL2 cells transformed by Epstein-Barr virus (EBV), activates the c-Myc and NF-κB pathways in BC3 and LCL1 cells, and induces necrotic cell death in B cells infected with gammaherpes virus. Cellocidin (100-200 ppm) is protective against bacterial leaf blight in rice plants and inhibits α-ketoglutarate oxidation in X. oryzae, the bacterium that causes leaf blight, when used at a concentration of 1 ppm, suggesting that it inhibits the citric acid cycle. Formulations containing cellocidin have been used as agricultural pesticides.
Chemical Properties
CREAM TO BEIGE FINE CRYSTALLINE POWDER
Uses
Cellocidin is a small neutral alkyne produced by a number of Streptomyces species, first discovered by Suzuki and colleagues in 1958. Cellocidin has a broad antibacterial, antifungal and antitumor profile due to its ability to react with endogenous thiols like cysteine and glutathione. Cellocidin occurs as a weak active in many bioassays using actinomycete crude extracts and is thus a useful standard for chemical and bioassay dereplication.
Definition
ChEBI: A dicarboxylic acid diamide resulting from the formal condensation of both of the carboxy groups of butynedioic acid with ammonia. An antibacterial agent produced by Streptomyces chibaensis.
Purification Methods
Acetylenedicarboxamide crystallises from MeOH and H2O [m 190-192o(dec) as hemihydrate]. When prepared from the ester + NH3 it has m 213o(dec). Also a melting point of 290-292o(dec) has been reported. [Saggimo J Org Chem 22 1171 1857, Kharash et al. J Org Chem 10 392 1945, Blomquist & Winslow J Org Chem 10 156 1945, Beilstein 2 I 317, 2 III 1995, 2 IV 2295.]
ACETYLENEDICARBOXAMIDE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | 1026@dideu.com | China | 9116 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49999 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006608290; 18621169109 | market03@meryer.com | China | 40241 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Hangzhou Yuhao Chemical Technology Co., Ltd | 0571-82693216 | info@yuhaochemical.com | China | 9394 | 52 |