ChemicalBook
Chinese Japanese Germany Korea

Dapoxetine hydrochloride

Dapoxetine hydrochloride
Dapoxetine hydrochloride structure
CAS No.
129938-20-1
Chemical Name:
Dapoxetine hydrochloride
Synonyms
LY-21044;LY-210448;DAPOXETINE HCL;Rimonabant 75000;DL-Dapoxteine HCL;Mixed spin Dapoxetine;Dapoxetine Impurity 11;Dapoxetine hcl for R&D;Dapoxetine hydrochloride;(S)-Dapoxetine hydrochloride
CBNumber:
CB7104314
Molecular Formula:
C9H7ClN2O5
Formula Weight:
258.62
MOL File:
129938-20-1.mol

Dapoxetine hydrochloride Properties

Melting point:
175-1790C
alpha 
D +135.78° (c = 2.18 in methanol)
storage temp. 
-20°C Freezer
solubility 
DMSO: ≥20mg/mL
form 
powder
color 
white
optical activity
[α]/D +125 to +135°, c = 1 in methanol
Merck 
14,2821
CAS DataBase Reference
129938-20-1(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,N
Risk Statements  22-36-50/53
Safety Statements  36-60-61
RIDADR  UN 3077 9 / PGIII
WGK Germany  3
HS Code  29221990
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H413 May cause long lasting harmful effects to aquatic life Hazardous to the aquatic environment, long-term hazard Category 4
Precautionary statements:
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Dapoxetine hydrochloride price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich D7071 Dapoxetine hydrochloride ≥98% (HPLC) 129938-20-1 10mg $91.6 2018-11-13 Buy
Sigma-Aldrich D7071 Dapoxetine hydrochloride ≥98% (HPLC) 129938-20-1 50mg $359 2018-11-13 Buy
TCI Chemical D4761 Dapoxetine Hydrochloride >98.0%(HPLC) 129938-20-1 1g $129 2018-11-22 Buy
TCI Chemical D4761 Dapoxetine Hydrochloride >98.0%(HPLC) 129938-20-1 5g $436 2018-11-22 Buy
Cayman Chemical 9002488 Dapoxetine (hydrochloride) ≥98% 129938-20-1 5mg $150 2018-11-19 Buy

Dapoxetine hydrochloride Chemical Properties,Uses,Production

Description

PE is the most common form of male sexual dysfunction affecting 20-40% of men globally at some point in their lives. Ejaculation is a reflex comprising different sensory pathways, motor centers, and nerve pathways. This ejaculatory reflex has been shown to be controlled primarily by serotonin and dopamine. Dapoxetine is a short-acting SSRI. It is differentiated from the existing SSRI treatments for PE by the fact that it can be administered on an as-needed basis. In healthy subjects, dapoxetine is rapidly absorbed after oral administration with a peak plasma concentration (Tmax) occurring between 1.4 and 2 h.
Dapoxetine also showed statistically significant improvements in perceived control over ejaculation, PE-related personal distress, and other patient-reported outcomes in all five trials. Dapoxetine treatment was generally well tolerated, with low incidences of discontinuation syndrome, sexual dysfunction, and treatment-emergent mood symptoms. The most common adverse events with dapoxetine included nausea, diarrhea, headache, dizziness, and somnolence.

Chemical Properties

Off-white Cryst

Originator

Lilly (US)

Uses

Selective serotonin reuptake inhibitor (SSRI)

Uses

Dapoxetine hydrochloride is a short-acting novel selective serotonin reuptake inhibitor marketed for the treatment of premature ejaculation in men. Premature ejaculation (PE) is the most common male sexual disorder, estimated to affect up to 30% of men. D

Uses

A selective serotonin reuptake inhibitor

brand name

Priligy

Chemical Synthesis

Dapoxetine can be synthesized in four chemical steps starting from R-1phenyl- 1,3-propanediol via selective tosylation of the primary hydroxy group with p-toluenesulfonyl chloride, triethylamine and 4-(dimethylamino) pyridine (DMAP), and subsequent condensation with 1naphthol by means of sodium- or lithium hydroxide to yield R-3-(1naphthyloxy)- 1-phenylpropanol as the key intermediate. Conversion of the alcohol group to the corresponding mesylate with methanesulfonyl chloride, triethylamine, and DMAP, followed by treatment with dimethylamine affords dapoxetine, which is then acidified to its hydrochloride salt.

Dapoxetine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products


Dapoxetine hydrochloride Suppliers

Global( 259)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3203 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21935 58
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 1529 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20676 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32452 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 892 55
Meihua Biological Technology Co.,Ltd
15175972705
031145896235 sales@hbmeihua.cn CHINA 211 58
Hebei Chisure Biotechnology Co., Ltd.
+8613292890173
0311 66567340 luna@speedgainpharma.com CHINA 1019 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 25796 58
Hebei Huanhao Biotechnology Co., Ltd.
86-0311-83975816 whatsapp +8618034554576
86-0311-83975816 grace@hbhuanhao.com CHINA 704 58

View Lastest Price from Dapoxetine hydrochloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-06 S-Dapoxetine hydrochloride
129938-20-1
US $10.00 / KG 1KG 995 20KG career henan chemical co
2019-07-03 Dapoxetine hydrochloride
129938-20-1
US $10.00 / KG 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.
2018-07-30 Dapoxetine hydrochloride
129938-20-1
US $10.00 / KG 10KG 99% 500kg/month Hebei Chisure Biotechnology Co., Ltd.

129938-20-1(Dapoxetine hydrochloride)Related Search:


Copyright 2017 © ChemicalBook. All rights reserved