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7-Deaza-2'-C-methyladenosine

7-Deaza-2'-C-methyladenosine structure

CAS No.: 443642-29-3

Chemical Name:: 7-Deaza-2'-C-methyladenosine

Synonyms: MK-608;MK-0608;Lamevudine;7-deaza-2C-Me-A;2'--C-Meth yltubercidin;2'-b-C-methyl tubercidin;7-Deaza-2'-C-methyladenosine;7-Deaza-2'-C-Methyladenosine;7H-PYRROLO[2,3-D]PYRIMIDIN-4-A;2’-b-C-Methyl-7-deazaadenosine

CBNumber:: CB71074003

Molecular Formula:: C12H16N4O4

Molecular Weight:: 280.28

MDL Number:: MFCD14584964

MOL File:: 443642-29-3.mol

Last updated:2023-12-20 10:51:19

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7-Deaza-2'-C-methyladenosine Properties

Melting point	222 °C(Solv: methanol (67-56-1); acetonitrile (75-05-8))
Boiling point	620.7±55.0 °C(Predicted)
Density	1.75±0.1 g/cm3(Predicted)
storage temp.	2-8°C
pka	12.51±0.70(Predicted)
InChI	InChI=1/C12H16N4O4/c1-12(19)8(18)7(4-17)20-11(12)16-3-2-6-9(13)14-5-15-10(6)16/h2-3,5,7-8,11,17-19H,4H2,1H3,(H2,13,14,15)/t7-,8-,11-,12-/s3
InChIKey	IRZRJANZDIOOIF-ULJXVLPWNA-N
SMILES	C[C@]1([C@@H]([C@@H](CO)O[C@H]1N1C=CC2=C(N=CN=C12)N)O)O \|&1:1,2,3,7,r\|
FDA UNII	QRR62J6WEF

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P280-P301+P312-P302+P352-P305+P351+P338

7-Deaza-2'-C-methyladenosine price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML3200	MK-0608 ≥98% (HPLC)	443642-29-3	5MG	$112	2024-03-01	Buy
Sigma-Aldrich	SML3200	MK-0608 ≥98% (HPLC)	443642-29-3	25MG	$360	2024-03-01	Buy
TRC	D201650	7-Deaza-2''-C-methyladenosine	443642-29-3	25mg	$160	2021-12-16	Buy
TRC	D201650	7-Deaza-2''-C-methyladenosine	443642-29-3	100mg	$605	2021-12-16	Buy
Biosynth Carbosynth	ND08351	7-Deaza-2'-C-methyladenosine	443642-29-3	10mg	$85	2021-12-16	Buy

Product number	Packaging	Price	Buy
SML3200	5MG	$112	Buy
SML3200	25MG	$360	Buy
D201650	25mg	$160	Buy
D201650	100mg	$605	Buy
ND08351	10mg	$85	Buy

7-Deaza-2'-C-methyladenosine Chemical Properties,Uses,Production

Uses

7-Deaza-2''-C-methyladenosine is a hepatitis C virus (HCV) polymerase inhibitor.

Definition

MK 0608 (7-Deaza-2'-C-methyladenosine) is an anti-viral agent against Hepatitis C Virus (HCV). It has been shown to inhibit viral RNA replication in the subgenomic HCV genotype 1b replicon, with a 50% effective concentration (EC50) of 0.3 μM (EC90 = 1.3 μM). To determine efficacy in vivo, MK-0608 was administered to HCV-infected chimpanzees, resulting in dose- and time-dependent decreases in plasma viral loads. In separate experiments, chimpanzees dosed for 7 days with MK-0608 at 0.2 and 2 mg per kg of body weight per day by intravenous administration experienced average reductions in viral load of 1.0 and >5 log10 IU/ml, respectively.

Solubility in organics

Soluble in DMSO, not in water.

storage

Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

7-Deaza-2'-C-methyladenosine Preparation Products And Raw materials

Raw materials

Preparation Products

7-Deaza-2'-C-methyladenosine Suppliers

Global( 56)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
PANNACEAN(HENAN)MEDICINE SCIENCE TECHNOLOGIES LTD	0371-55159968 18137130222	haifeng.zhang@pannacean.com	China	387	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Nanjing Baifuli Technology Co., Ltd.	+86-15335185688	sales@unisyn.cn	CHINA	332	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
NewCan Biotech Limited	+86-0571-86912261 +8613735419629	sales@newcanbio.com	China	10027	58
changzhou huayang technology co., ltd	+8615250961469	2571773637@qq.com	China	9821	58
Alfa Chemistry	+1-5166625404	Info@alfa-chemistry.com	United States	21317	58
Wuhu Nuowei chemistry Co., Ltd.	+86-0553-2911116-802 +undefined17756524438	sales1@nuowei-chem.com	China	1642	58

Supplier	Advantage
PANNACEAN(HENAN)MEDICINE SCIENCE TECHNOLOGIES LTD	58
career henan chemical co	58
Nanjing Baifuli Technology Co., Ltd.	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
TargetMol Chemicals Inc.	58
NewCan Biotech Limited	58
changzhou huayang technology co., ltd	58
Alfa Chemistry	58
Wuhu Nuowei chemistry Co., Ltd.	58

View Lastest Price from 7-Deaza-2'-C-methyladenosine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-08-06	Lamevudine 443642-29-3	US $5.00 / KG	1KG	99%	1ton	Career Henan Chemical Co

Lamevudine
443642-29-3
US $5.00 / KG
99%
Career Henan Chemical Co

7-Deaza-2'-C-methyladenosine Spectrum

Lamevudine(443642-29-3)¹HNMR

Lamevudine (2R,3R,4R,5R)-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)-3-methyltetrahydrofuran-3,4-diol (2R,3R,4R,5R)-2-(4-aMino-7H-pyrrolo[2,3-d]pyriMidin-7-yl)-5-(hyd MK-0608 7H-PYRROLO[2,3-D]PYRIMIDIN-4-A 7-(2-C-Methyl-beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (2R,3R,4R,5R)-2-(4-Aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)-3-methyl-tetrahydrofuran-3,4-diol 7-Deaza-2'-C-methyladenosine 7-(2-C-Methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine 2'-b-C-methyl tubercidin 4-Amino-7-(2--C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine 2'--C-Meth yltubercidin 4-Amino-7-(2-beta-C-methyl-beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine MK-608 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-(2-C-methyl-β-D-ribofuranosyl)- 2’-beta-C-methyl tubercidin, 4-Amino-7-(2-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo [2,3-d]pyrimidine, MRK608 (2R,3R,4R,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol 7-deaza-2C-Me-A 2’-b-C-Methyl tubercidin,2’-b-C-Methyl-7-deazaadenosine, MKR608, antiviral, HCV inhibitor 2’-b-C-Methyl-7-deazaadenosine inhibit,MK-0608,Inhibitor,MK 0608,HCV,MK0608,Hepatitis C virus 7H-Pyrrolo[2,3-D]pyrimidin-4-amine,7-(2-c-methyl-b-d-ribofuranosyl)- 7-?(2-?C-?methyl-?β-?D-?ribofuranosyl)?-7H-?Pyrrolo[2,?3-?d]?pyrimidin-?4-?amine 7-Deaza-2'-C-Methyladenosine 443642-29-3