eperezolid
- CAS No.
- 165800-04-4
- Chemical Name:
- eperezolid
- Synonyms
- U 100592;PNU 100592;eperezolid;Eperezolid-d3;Eperezolid (PNU-100592;PNU-100592;PNU100592;U-100592;PNU-100592; PNU100592; PNU 100592;Bacterial,PNU100592,Inhibitor,inhibit,Eperezolid,PNU 100592,Antibiotic;(S)-N-[[3-[3-Fluoro-4-[4-(hydroxyacetyl)-1-piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide;(S)-N-((3-(3-Fluoro-4-(4-(2-hydroxyacetyl)piperazin-1-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide
- CBNumber:
- CB71074285
- Molecular Formula:
- C18H23FN4O5
- Molecular Weight:
- 394.4
- MDL Number:
- MFCD00941980
- MOL File:
- 165800-04-4.mol
- MSDS File:
- SDS
| Melting point | 174-176℃ |
|---|---|
| Boiling point | 701.2±60.0 °C(Predicted) |
| Density | 1.370±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | insoluble in EtOH; insoluble in H2O; ≥14.05 mg/mL in DMSO |
| form | Powder |
| pka | 13.84±0.10(Predicted) |
| FDA UNII | C460ZSU1OW |
eperezolid price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | E565742 | Eperezolid-d3 | 165800-04-4 | 1mg | $220 | 2021-12-16 | Buy |
| ChemScene | CS-2793 | Eperezolid 96.23% | 165800-04-4 | 5mg | $348 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0136369 | ACETAMIDE, N-[[(5S)-3-[3-FLUORO-4-[4-(2-HYDROXYACETYL)-1-PIPERAZINYL]PHENYL]-2-OXO-5-OXAZOLIDINYL]METHYL]- 95.00% | 165800-04-4 | 5MG | $499.75 | 2021-12-16 | Buy |
| ChemScene | CS-2793 | Eperezolid 96.23% | 165800-04-4 | 10mg | $600 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611774 | Eperezolid | 165800-04-4 | 10mg | $615.4 | 2021-12-16 | Buy |
eperezolid Chemical Properties,Uses,Production
Uses
Antibacterial.
Uses
Eperezolid is an antimicrobial.
Biological Activity
mic50: 0.5, 1.0, 2.0, 1.0, 16.0 and 2.0 mg/l for pcptostreptococcus, propionibacterium acnes, ciostridium pefringens, clostridium dijiicile, bactrroidesjagilis, and fusobacterium, respectivleyanaerobic bacteria are a common cause of serious infections. anaerobic species which predominate in clinical infections include the bacteroides fragilis group, clostridium spp. and peptostreptococcus spp. the oxazolidinones are a novel class of synthetic antimicrobials inhibiting the initiation of protein synthesis. two compounds of this class, eperezolid and linezolid have been shown to inhibit enterococcus faecalis and enterococcus faecium.
in vitro
ninety per cent of all tested propionibacterium acnes (30 strains), peptostreptococccuj spp. (50 strains), c. perjringens (50 strains) and c. dficile (50 strains) were inhibited by <2 mg/l eperezolid. linezolid showed higher activity (mic90 4.0 mg/l) against b. jragilis (100 strains) compared to eperezolid (mic90 16 mg/l) [1].
in vivo
the in vivo effectiveness of eperezolid and linezolid against one strain each of enterococcus faecalis and vancomycin-resistant enterococcus faecium was examined in a rat intraabdominal abscess model. eperezolid was ineffective at doses of 25 mg/kg of body weight twice daily for the reductions in abscess bacterial density for e. faecalis. against e. faecium infections, intravenous eperezolid was effective, reducing densities approximately 2 log10 cfu/g [2].
References
[1] edlund c, oh h, nord ce. in vitro activity of linezolid and eperezolid against anaerobic bacteria. clin microbiol infect. 1999;5(1):51-53.
[2] schülin t, thauvin-eliopoulos c, moellering rc jr, eliopoulos gm. activities of the oxazolidinones linezolid and eperezolid in experimental intra-abdominal abscess due to enterococcus faecalis or vancomycin-resistant enterococcus faecium. antimicrob agents chemother. 1999;43(12):2873-6.
[3] schaadt rd, batts dh, daley-yates pt, pawsey sd, stalker dj, zurenko ge. serum inhibitory titers and serum bactericidal titers for human subjects receiving multiple doses of the antibacterial oxazolidinones eperezolid and linezolid. diagn microbiol infect dis. 1997;28(4):201-4.
eperezolid Preparation Products And Raw materials
Raw materials
Preparation Products
eperezolid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Wuxi Donghe Pharmaceutical Technology Co., Ltd. | 63313187 15358055255 | 63313187@qq.com | China | 1974 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2784 | 58 |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2384 | 58 |
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