2,6-Dioxopiperidine-3-ammonium chloride
- CAS No.
- 24666-56-6
- Chemical Name:
- 2,6-Dioxopiperidine-3-ammonium chloride
- Synonyms
- 3-Amino-2,6-piperidinedione hydrochloride;2,6-dioxopiperidin-3-aminium chloride;Pomalidomide Impurity 6;2,6-Dioxopiperidine-3-ammonium;RSYY（Avanafil)-31;Lenalidomide/Pomadoamine;Lenalidomide EP Impurity-A;Lenalidomide Impurity 6 HCl;Lenalidomide Impurity 9 HCl;Lenalidomide Impurity 2 HCl
- CBNumber:
- CB71113128
- Molecular Formula:
- C5H9ClN2O2
- Molecular Weight:
- 164.59016
- MDL Number:
- MFCD11042437
- MOL File:
- 24666-56-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 3-Amino-2,6-piperidinedione Hydrochloride | A2691 | 5G | $32 |
| 3-Amino-2,6-piperidinedione Hydrochloride | A2691 | 25G | $99 |
| 3-Aminopiperidine-2,6-dione hydrochloride salt | FA11978 | 0.05kg | $162.25 |
| 3-Aminopiperidine-2,6-dione hydrochloride salt | FA11978 | 0.1kg | $259.6 |
| 3-Aminopiperidine-2,6-dione hydrochloride salt | FA11978 | 0.25kg | $519.2 |
| More product size | |||
| Melting point | 120 °C (approx) |
|---|---|
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO (Slightly, Heated), Methanol (Sparingly, Sonicated) |
| form | powder |
| color | White |
| InChI | InChI=1S/C5H8N2O2.ClH/c6-3-1-2-4(8)7-5(3)9;/h3H,1-2,6H2,(H,7,8,9);1H |
| InChIKey | YCPULGHBTPQLRH-UHFFFAOYSA-N |
| SMILES | C1CC(N)C(=O)NC1=O.Cl |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P271-P261-P280 |
| Risk Statements | 20/21/22 |
| Safety Statements | 3/9-36/37 |
| HS Code | 29339900 |
2,6-Dioxopiperidine-3-ammonium chloride price More Price(79)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | A2691 | 3-Amino-2,6-piperidinedione Hydrochloride | 24666-56-6 | 5G | $32 | 2026-04-30 | Buy |
| TCI Chemical | A2691 | 3-Amino-2,6-piperidinedione Hydrochloride | 24666-56-6 | 25G | $99 | 2026-04-30 | Buy |
| Biosynth | FA11978 | 3-Aminopiperidine-2,6-dione hydrochloride salt | 24666-56-6 | 0.05kg | $162.25 | 2026-06-04 | Buy |
| Biosynth | FA11978 | 3-Aminopiperidine-2,6-dione hydrochloride salt | 24666-56-6 | 0.1kg | $259.6 | 2026-06-04 | Buy |
| Biosynth | FA11978 | 3-Aminopiperidine-2,6-dione hydrochloride salt | 24666-56-6 | 0.25kg | $519.2 | 2026-06-04 | Buy |
2,6-Dioxopiperidine-3-ammonium chloride Chemical Properties,Uses,Production
Description
2,6-Dioxopiperidine-3-ammonium chloride is a reagent for preparing lenalidomide that can induce ubiquitination and degradation of CK1α in del (5q) MDS. It can also be used to prepare phthalimide conjugates that can promote ligand-dependent target protein degradation. Moreover, it is also a metabolite of thalidomide (T338850) that inhibits FGF-induced angiogenesis.
Chemical Properties
White crystal
Uses
2,6-Dioxopiperidine-3-ammonium chloride can be used as an important intermediate of antineoplastic drug lenalidomide.
Synthesis
24666-55-5
24666-56-6
General procedure for the synthesis of 3-aminopiperidine-2,6-dione hydrochloride from benzyl (2,6-dioxopiperidin-3-yl)carbamate: Benzyl (2,6-dioxopiperidin-3-yl)carbamate (4.00 g, 15.0 mmol) was dissolved in methanol (200 mL) and 2N HCl solution (15 mL) was added. Subsequently, 5% Pd-C catalyst (100 mg) was added and the hydrogenation reaction was carried out at 60 psi hydrogen pressure for 4 hours. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to dryness to afford 3-aminopiperidine-2,6-dione hydrochloride as a white solid (2.61 g, 100% yield) with a melting point of 245 °C (decomposition, ignition temperature 235 °C).1H NMR (400 MHz, DMSO-D6) δ ppm: 11.22 (br s, 1H), 8.68 (br s, 3H), 4.20 (dd, J = 13.0, 5.3 Hz, 1H), 2.77-2.65 (m, 1H), 2.64-2.56 (m, 1H), 2.27-2.19 (m, 1H), 2.09-1.97 (m, 1H).
References
[1] Patent: WO2008/7979, 2008, A1. Location in patent: Page/Page column 13
[2] Patent: CN108218833, 2018, A. Location in patent: Paragraph 0043; 0044; 0057; 0058; 0063; 0071; 0072
[3] Patent: WO2018/154516, 2018, A1. Location in patent: Page/Page column 7-8
[4] Bioorganic and Medicinal Chemistry Letters, 1999, vol. 9, # 11, p. 1625 - 1630
2,6-Dioxopiperidine-3-ammonium chloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jiangsu Boquan Biotechnology Co., Ltd. | +86-18168774353 | boquanshengwu003@boquansw.com | China | 248 | 58 |
| Huanfu Industrial Co.，（Shanghai）Ltd. | +86-18001856580 | 2415195517@qq.com | China | 43 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 | deasea125996@gmail.com | China | 2451 | 58 |
| SHANDONG BOYUAN PHARMACEUTICAL CO., LTD. | +86-531-88625728 +86-15806417970 | sales@boyuanpharm.com | China | 181 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20111 | 58 |
| Rongchuang International | +86-13175533356 +86-13175533356 | kevin@rongchuangintl.com | China | 256 | 58 |
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 877 | 50 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29626 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 14034 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1796 | 55 |
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View Lastest Price from 2,6-Dioxopiperidine-3-ammonium chloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-17 | 2,6-Dioxopiperidine-3-ammonium chloride
24666-56-6
|
$1.00-10.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-08-08 | 3-Amino-2,6-piperidinedione hydrochloride
24666-56-6
|
10kg | 99.0%min | 3mt | Hangzhou ICH Biofarm Co., Ltd | ||
 |
2026-08-07 | 2,6-Dioxopiperidine-3-ammonium chloride
24666-56-6
|
1kg | 99% | 99999 | Rongchuang International |
-
- 2,6-Dioxopiperidine-3-ammonium chloride
24666-56-6
- $1.00-10.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 3-Amino-2,6-piperidinedione hydrochloride
24666-56-6
- $0.00
- 99.0%min
- Hangzhou ICH Biofarm Co., Ltd
-
- 2,6-Dioxopiperidine-3-ammonium chloride
24666-56-6
- $0.00
- 99%
- Rongchuang International
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