ChemicalBook >> CAS DataBase List >>Valspodar

Valspodar

CAS No.
121584-18-7
Chemical Name:
Valspodar
Synonyms
Psc 833;CS-51;AMdray;Valpodar;Valspodar;Sdz-psc-833;Sdz psc 833;Valspodar, >=98%;PSC833(Valspodar);Valspodar (PSC-833)
CBNumber:
CB71116624
Molecular Formula:
C63H111N11O12
Molecular Weight:
1214.62
MDL Number:
MFCD00907207
MOL File:
121584-18-7.mol
MSDS File:
SDS
Modify Date:2022-12-21 16:56:50

Valspodar Properties

Melting point 143-145°C
alpha D20 -255.1° (c = 0.5 in CHCl3)
Boiling point 1290.1±65.0 °C(Predicted)
Density 1.015±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility Chloroform (Slightly), Methanol (Slightly)
pka 12.45±0.70(Predicted)
form powder
color white to beige
FDA UNII Q7ZP55KF3X
NCI Dictionary of Cancer Terms PSC 833
NCI Drug Dictionary Amdray

SAFETY

Risk and Safety Statements

WGK Germany  3

Valspodar price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0572 Valspodar ≥98% (HPLC) 121584-18-7 5mg $184 2023-01-07 Buy
Sigma-Aldrich SML0572 Valspodar ≥98% (HPLC) 121584-18-7 25mg $723 2023-01-07 Buy
Cayman Chemical 20391 PSC 833 ≥95% 121584-18-7 500μg $25 2023-01-06 Buy
Cayman Chemical 20391 PSC 833 ≥95% 121584-18-7 1mg $48 2023-01-06 Buy
Cayman Chemical 20391 PSC 833 ≥95% 121584-18-7 5 mg $163 2023-01-06 Buy
Product number Packaging Price Buy
SML0572 5mg $184 Buy
SML0572 25mg $723 Buy
20391 500μg $25 Buy
20391 1mg $48 Buy
20391 5 mg $163 Buy

Valspodar Chemical Properties,Uses,Production

Description

PSC 833 is a non-immunosuppressant derivative of cyclosporine and potent multidrug-resistance (MDR) modulator. It restores sensitivity of MDR-P388 murine leukemia cells to cytostatic agents when used at concentrations of 70, 33, 45, 34, and 26 nM in combination with colchicine, vincristine , daunorubicin , doxorubicin , and etoposide , respectively. PSC 833 inhibits basal-to-apical transport and increases apical-to-basal transport of [14C]docetaxel in LLC-GA5-COLO150 cells that overexpress human P-glycoprotein (P-gp). In vivo, PSC 833 increases survival time in MDR-P388 tumor-bearing mice and in an MDR-L1210 leukemia mouse xenograft model when administered in combination with doxorubicin. PSC 833 also prolongs the anti-hyperalgesic effects of intraperitoneally administered pregabalin in a mouse model of cold stress-induced central pain.

Chemical Properties

White Solid

Uses

Valspodar/ PSC-833 has been used as a ABCB1 (P-glycoprotein) inhibitor.

Uses

Antineoplastic adjunct (chemosensitizer).

brand name

Amdray (Novartis).

Biochem/physiol Actions

Valspodar is a nonimmunosuppressive cyclosporin analog and potent P-glycoprotein (MDR1) inhibitor. Valspodar reverses multidrug resistance (MDR) by inhibiting cellular drug efflux mediated by P-glycoprotein.

Valspodar Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 113)Suppliers
Supplier Tel Email Country ProdList Advantage
Alpha Biopharmaceuticals Co., Ltd
+86-411-39042497 +8613921981412 sales@alphabiopharm.com China 883 58
ATK CHEMICAL COMPANY LIMITED
21-51619050 ivan@atkchemical.com China 31323 60
Biochempartner
0086-13720134139 candy@biochempartner.com CHINA 967 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 47427 58
Zhuozhou Wenxi import and Export Co., Ltd
+8613111626072 zzwenxi@126.com CHINA 13170 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897、88216896 13588875226 sales@hzclap.com CHINA 6458 58
Baoji Guokang Bio-Technology Co., Ltd.
0917-3909592 13892490616 gksales1@gk-bio.com CHINA 9392 58
Xi'an ZB Biotech Co.,Ltd
sales03@xazbbio.com CHINA 723 58
Henan Alfa Chemical Co., Ltd
+8618339805032 alfa4@alfachem.cn China 14226 58
Nextpeptide Inc
+86-0571-81612335 +8613336028439 sales@nextpeptide.com China 19915 58

View Lastest Price from Valspodar manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Valspodar pictures 2022-03-24 Valspodar
121584-18-7
US $1.00 / g 1g 99% 1ton Henan Guange Biotechnology Co. LTD
Valspodar pictures 2021-07-13 Valspodar
121584-18-7
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
Valspodar pictures 2021-07-10 Valspodar
121584-18-7
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
  • Valspodar pictures
  • Valspodar
    121584-18-7
  • US $1.00 / g
  • 99%
  • Henan Guange Biotechnology Co. LTD
  • Valspodar pictures
  • Valspodar
    121584-18-7
  • US $15.00-10.00 / KG
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd
  • Valspodar pictures
  • Valspodar
    121584-18-7
  • US $15.00-10.00 / KG
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd

Valspodar Spectrum

Valspodar 3'-Keto-bmt(1)-Val(2)-cyclosporin a Cyclosporin A, 6-((R-(E))-6,7-didehydro-N,4-dimethyl-3-oxo-L-2-aminooctanoic acid)-7-L-valine- Sdz psc 833 Sdz-psc-833 Cyclo[[(2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoyl]-L-valyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl] 6-[(2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoicacid]-7-L-valine-cyclosporinA Valspodar(PSC-833,AMdray) 6-[(2S,4R,6E)-4-Methyl-2-(MethylaMino)-3- oxo-6-octenoic Acid]ccyclosporin D 6-[[R-(E)]-6,7-Didehydro-N,4-diMethyl-3-oxo-L-2-aMinooctanoic acid]-7-L-valinecyclosporin A AMdray Valpodar PSC833(Valspodar) Cyclosporin A,6-[(2S,4R,6E)-4-Methyl-2-(MethylaMino)-3-oxo-6-octenoic acid]-7-L-valine- Valspodar (PSC-833) [3′-Desoxy-3′-oxo-MeBmt]1-[Val]2-cyclosporin 6-[(2S,4R,6E)-4-Methyl-2-(methylamino)-3-oxo-6-octenoic acid]cyclosporin D PSC833 - Specific MDR1/P-gp Inhibitor Valspodar, >=98% CS-51 PSC 833; PSC-833; PSC833 Psc 833 121584-18-7 Intermediates & Fine Chemicals Peptides Pharmaceuticals