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Valspodar

Valspodar structure

CAS No.: 121584-18-7

Chemical Name:: Valspodar

Synonyms: Psc 833;CS-51;AMdray;Valpodar;Valspodar;Sdz-psc-833;Sdz psc 833;Valspodar, >=98%;PSC833(Valspodar);Valspodar (PSC-833)

CBNumber:: CB71116624

Molecular Formula:: C63H111N11O12

Molecular Weight:: 1214.62

MDL Number:: MFCD00907207

MOL File:: 121584-18-7.mol

MSDS File:: SDS

Last updated:2023-09-07 11:57:21

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Valspodar Properties

Melting point	143-145°C
alpha	D20 -255.1° (c = 0.5 in CHCl3)
Boiling point	1290.1±65.0 °C(Predicted)
Density	1.015±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	12.45±0.70(Predicted)
form	powder
color	white to beige
InChIKey	YJDYDFNKCBANTM-QCWCSKBGSA-N
NCI Dictionary of Cancer Terms	PSC 833
FDA UNII	Q7ZP55KF3X
NCI Drug Dictionary	Amdray

SAFETY

Risk and Safety Statements

WGK Germany	3

Valspodar price More Price(23)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML0572	Valspodar ≥98% (HPLC)	121584-18-7	5mg	$189	2024-03-01	Buy
Sigma-Aldrich	SML0572	Valspodar ≥98% (HPLC)	121584-18-7	25mg	$741	2024-03-01	Buy
Cayman Chemical	20391	PSC 833 ≥95%	121584-18-7	500μg	$29	2024-03-01	Buy
Cayman Chemical	20391	PSC 833 ≥95%	121584-18-7	1mg	$55	2024-03-01	Buy
Cayman Chemical	20391	PSC 833 ≥95%	121584-18-7	5 mg	$184	2024-03-01	Buy

Product number	Packaging	Price	Buy
SML0572	5mg	$189	Buy
SML0572	25mg	$741	Buy
20391	500μg	$29	Buy
20391	1mg	$55	Buy
20391	5 mg	$184	Buy

Valspodar Chemical Properties,Uses,Production

Description

PSC 833 is a non-immunosuppressant derivative of cyclosporine and potent multidrug-resistance (MDR) modulator. It restores sensitivity of MDR-P388 murine leukemia cells to cytostatic agents when used at concentrations of 70, 33, 45, 34, and 26 nM in combination with colchicine, vincristine , daunorubicin , doxorubicin , and etoposide , respectively. PSC 833 inhibits basal-to-apical transport and increases apical-to-basal transport of [¹⁴C]docetaxel in LLC-GA5-COLO150 cells that overexpress human P-glycoprotein (P-gp). In vivo, PSC 833 increases survival time in MDR-P388 tumor-bearing mice and in an MDR-L1210 leukemia mouse xenograft model when administered in combination with doxorubicin. PSC 833 also prolongs the anti-hyperalgesic effects of intraperitoneally administered pregabalin in a mouse model of cold stress-induced central pain.

Chemical Properties

White Solid

Uses

Valspodar/ PSC-833 has been used as a ABCB1 (P-glycoprotein) inhibitor.

Uses

Valspodar(PSC-833), a 2nd-generation ABC transporter inhibitor, limits HCMV infection as demonstrated by the decrease in IE2 expression of virus-infected cells. As a cyclosporin D analog, it has been shown to be a much more effective inhibitor of MDR than cyclosporin A and to be less toxic[1-2].

Uses

Antineoplastic adjunct (chemosensitizer).

Definition

ChEBI: SDZ PSC 833 is a homodetic cyclic peptide.

brand name

Amdray (Novartis).

Biochem/physiol Actions

Valspodar is a nonimmunosuppressive cyclosporin analog and potent P-glycoprotein (MDR1) inhibitor. Valspodar reverses multidrug resistance (MDR) by inhibiting cellular drug efflux mediated by P-glycoprotein.

Cytotoxicity

Cells treated with increasing concentrations of valspodar over a 9-day period show minimal cytotoxicity. It appears to be neither immunosuppressive nor nephrotoxic with the ability to achieve levels in the blood (1 μm) capable of reversing drug resistance without excessive toxicity[1].

storage

Store at -20°C

References

[1] Friedenberg W, et al. Phase III study of PSC-833 (valspodar) in combination with vincristine, doxorubicin, and dexamethasone (valspodar/VAD) versus VAD alone in patients with recurring or refractory multiple myeloma (E1A95). Cancer, 2006; 106: 830-838.
[2] Parsons J, et al. Valspodar limits human cytomegalovirus infection and dissemination. Antiviral Research, 2021; 193: 105124.

Valspodar Preparation Products And Raw materials

Raw materials

Preparation Products

Valspodar Suppliers

Global( 124)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
BOC Sciences	+16314854226	inquiry@bocsci.com	United States	19743	58
Alpha Biopharmaceuticals Co., Ltd	+86-411-39042497 +8613921981412	sales@alphabiopharm.com	China	886	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	967	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Baoji Guokang Bio-Technology Co., Ltd.	0917-3909592 13892490616	gksales1@gk-bio.com	China	9339	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19915	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58

Supplier	Advantage
BOC Sciences	58
Alpha Biopharmaceuticals Co., Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
Biochempartner	58
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Baoji Guokang Bio-Technology Co., Ltd.	58
Nextpeptide Inc	58
InvivoChem	58

View Lastest Price from Valspodar manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-07-13	Valspodar 121584-18-7	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
	2021-07-10	Valspodar 121584-18-7	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

Valspodar
121584-18-7
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Valspodar
121584-18-7
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Valspodar Spectrum

Valspodar(121584-18-7)MS

121584-18-7(Valspodar)Related Search:

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Vandetanib PF 543 ALK5 inhibitor II PF-543 (Citrate) CHIR-99021

1of2

Valspodar 3'-Keto-bmt(1)-Val(2)-cyclosporin a Cyclosporin A, 6-((R-(E))-6,7-didehydro-N,4-dimethyl-3-oxo-L-2-aminooctanoic acid)-7-L-valine- Sdz psc 833 Sdz-psc-833 Cyclo[[(2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoyl]-L-valyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl] 6-[(2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoicacid]-7-L-valine-cyclosporinA Valspodar(PSC-833,AMdray) 6-[(2S,4R,6E)-4-Methyl-2-(MethylaMino)-3- oxo-6-octenoic Acid]ccyclosporin D 6-[[R-(E)]-6,7-Didehydro-N,4-diMethyl-3-oxo-L-2-aMinooctanoic acid]-7-L-valinecyclosporin A AMdray Valpodar PSC833(Valspodar) Cyclosporin A,6-[(2S,4R,6E)-4-Methyl-2-(MethylaMino)-3-oxo-6-octenoic acid]-7-L-valine- Valspodar (PSC-833) [3′-Desoxy-3′-oxo-MeBmt]1-[Val]2-cyclosporin 6-[(2S,4R,6E)-4-Methyl-2-(methylamino)-3-oxo-6-octenoic acid]cyclosporin D PSC833 - Specific MDR1/P-gp Inhibitor Valspodar, >=98% CS-51 PSC 833; PSC-833; PSC833 Psc 833 (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-6,9,18,24-Tetraisobutyl-3,21,30-triisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-33-((R,E)-2-methylhex-4-enoyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone 121584-18-7 Intermediates & Fine Chemicals Peptides Pharmaceuticals