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Daunorubicin hydrochloride

Daunorubicin hydrochloride
Daunorubicin hydrochloride structure
CAS No.
23541-50-6
Chemical Name:
Daunorubicin hydrochloride
Synonyms
ondena;Cerubidine;daunoblastin;ndc0082-4155;daunoblastina;DAUNOBLASTINE;DAUNOMYCIN HCL;DAUNOMYCINE HCL;Daunorubicin HCI;DAUNORUBICIN HCL
CBNumber:
CB7113022
Molecular Formula:
C27H30ClNO10
Formula Weight:
563.98
MOL File:
23541-50-6.mol

Daunorubicin hydrochloride Properties

Melting point:
190°C (dec)
alpha 
D20 +248 ±5° (c = 0.05-0.1 in methanol)
storage temp. 
−20°C
solubility 
Freely soluble in water and in methanol, slightly soluble in alcohol, practically insoluble in acetone.
form 
solid
color 
red to deep red
λmax
477nm(H2O)(lit.)
Sensitive 
Hygroscopic
Merck 
14,2832
BRN 
4229221
Stability:
Stability
EPA Substance Registry System
5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3, 6-trideoxy-.alpha.-L-lyxo- hexopyranosyl)oxy]-7,8,9, 10-tetrahydro-6,8,11-trihydroxy- 1-methoxy-, hydrochloride, (8S,10S)-(23541-50-6)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,Xi
Risk Statements  22-40-42/43-36/37/38-20/21/22
Safety Statements  22-36/37-45-37/39-36-26
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  HB7878000
3-10
HazardClass  6.1(b)
PackingGroup  III
HS Code  29419059
Toxicity LD50 in mice (mg/kg): 26 i.v. (DiMarco, 1969)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled Sensitisation, respiratory Category 1 Danger P261, P285, P304+P341, P342+P311,P501
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P201 Obtain special instructions before use.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P281 Use personal protective equipment as required.
P284 Wear respiratory protection.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P342+P311 IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P405 Store locked up.

Daunorubicin hydrochloride price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 251800 Daunorubicin, Hydrochloride 23541-50-6 5mg $75.2 2018-11-20 Buy
Sigma-Aldrich 1164700 Daunorubicin hydrochloride United States Pharmacopeia (USP) Reference Standard 23541-50-6 200mg $1080.45 2018-11-20 Buy
TCI Chemical D4532 Daunorubicin Hydrochloride >98.0%(HPLC)(N) 23541-50-6 20mg $198 2018-11-22 Buy
TCI Chemical D4532 Daunorubicin Hydrochloride >98.0%(HPLC)(N) 23541-50-6 100mg $694 2018-11-22 Buy
Alfa Aesar J60224 Daunorubicin hydrochloride 23541-50-6 10mg $156 2018-11-13 Buy

Daunorubicin hydrochloride Chemical Properties,Uses,Production

Chemical Properties

Dark Red Crystals

Uses

Antineoplastic;DNA intercaling

Uses

anti-neoplastic LD50 in mice 26 mg/kg

Uses

A DNA intercalator which may suppress acute leukemia proliferation

Uses

Anthracycline antibiotic related to the rhodomycins. Antineoplastic

brand name

Cerubidine (Bedford); Cerubidine (Sanofi Aventis); Cerubidine (Wyeth).

General Description

Daunorubicin is available in 20- and 100-mg vials for reconstitution.The agent is given intravenously for the treatmentof acute nonlymphocytic and lymphocytic leukemia. Otherunlabeled uses include CML and Kaposi sarcoma. In general,its use is more limited than that of doxorubicin.Daunorubicin lacks the hydroxyl groups found at C-14 ofdoxorubicin. This leads to an increase in the amount of thealcohol metabolite daunorubicinol (active) arising as a resultof reduction of the side chain ketone. This, however, doesnot appear to lead to a significant increase in the occurrenceof cardiotoxicity compared with doxorubicin. The mechanismsof resistance and toxicities of daunorubicin are similarto that of doxorubicin; the major difference betweenthe two agents being the spectrum of cancers that they areused treat.
A liposomal form of daunorubicin is also availableknown as DaunoXome. The drug offers the same advantagesas those seen for the liposomal form of doxorubicin.

General Description

Orange-red powder. Thin red needles decomposing at 188-190°C. An anti-cancer drug.

Air & Water Reactions

Water soluble.

Reactivity Profile

Daunorubicin hydrochloride may emit toxic oxides of nitrogen when heated.

Biological Activity

Anticancer agent that is clinically used to treat nonlymphocytic leukaemia. Inhibits RNA and DNA synthesis and causes DNA fragmentation in vivo .

Daunorubicin hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products


Daunorubicin hydrochloride Suppliers

Global( 272)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3203 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21935 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20676 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688 bruce@xrdchem.cn CHINA 539 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24196 60
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6374 58
Hebei Chisure Biotechnology Co., Ltd.
+8613292890173
0311 66567340 luna@speedgainpharma.com CHINA 1019 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 25796 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23958 58
Accela ChemBio Inc.
(+1)-858-699-3322
(+1)-858-876-1948 info@accelachem.com United States 12233 58

View Lastest Price from Daunorubicin hydrochloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-20 Daunorubicin hydrochloride
23541-50-6
US $1.00 / KG 1G 98% 100KG career henan chemical co
2018-08-19 Daunorubicin hydrochloride
23541-50-6
US $1.00 / KG 1KG 95% 500KG career henan chemical co
2019-07-03 Daunorubicin hydrochloride
23541-50-6
US $10.00 / KG 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.

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