Naltrexone hydrochloride
- CAS No.
- 16676-29-2
- Chemical Name:
- Naltrexone hydrochloride
- Synonyms
- ReVia;Depade;nih8503;en1639a;Nalorex;Antaxone;4-D-butyl;Ccris 1168;NSC 409767;Nalmefene-3
- CBNumber:
- CB7121465
- Molecular Formula:
- C20H24ClNO4
- Molecular Weight:
- 377.87
- MDL Number:
- MFCD00069324
- MOL File:
- 16676-29-2.mol
- MSDS File:
- SDS
| Melting point | 274-2760C |
|---|---|
| storage temp. | 2-8°C |
| solubility | H2O: 50 mg/mL, clear, colorless |
| color | White to Off-White |
| Water Solubility | Soluble in water at 50mg/ml. |
| Sensitive | Light Sensitive |
| Merck | 13,6389 |
| BRN | 3580333 |
| CAS DataBase Reference | 16676-29-2(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| NCI Dictionary of Cancer Terms | naltrexone hydrochloride; ReVia |
| FDA UNII | Z6375YW9SF |
| NCI Drug Dictionary | Depade |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| Safety Statements | 22-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | QD2160000 | |||||||||
| F | 8-10 | |||||||||
| HS Code | 2932.99.7000 | |||||||||
| Toxicity | guinea pig,LD50,oral,1490mg/kg (1490mg/kg),Medicamentos de Actualidad. Vol. 21, Pg. 264, 1985. | |||||||||
| NFPA 704 |
|
Naltrexone hydrochloride price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | N3136 | Naltrexone hydrochloride | 16676-29-2 | 100mg | $105 | 2024-03-01 | Buy |
| Sigma-Aldrich | N3136 | Naltrexone hydrochloride | 16676-29-2 | 1g | $633 | 2024-03-01 | Buy |
| TCI Chemical | N1176 | Naltrexone Hydrochloride | 16676-29-2 | 250MG | $145 | 2024-03-01 | Buy |
| TCI Chemical | N1176 | Naltrexone Hydrochloride | 16676-29-2 | 1G | $433 | 2024-03-01 | Buy |
| Alfa Aesar | J60590 | Naltrexone hydrochloride | 16676-29-2 | 250mg | $155 | 2023-06-20 | Buy |
Naltrexone hydrochloride Chemical Properties,Uses,Production
Description
Naltrexone hydrochloride is a potent, long-acting, orally-effective narcotic antagonist useful in the management of narcotic addiction.
Chemical Properties
White Crystalline Powder
Originator
Endo (USA)
Uses
Narcotic antagonist, In treatment of?alcoholism
Uses
sulfonamide, carbonic anhydrase inhibitor, anti-glaucoma agent
Uses
Nonselective opioid receptor antagonist; congener of naloxone
Uses
Naltrexone hydrochloride has been used:
as an opioid antagonist, to analyse its effect on ethanol preference using Caenorhabditis elegans as a model.
to determine its effectiveness in reducing the preference for substance of abuse (SOA) like nicotine and cocaine using Caenorhabditis elegans as a model.
in the preparation of combinatorial drug, PXT3003 for treating Charcot-Marie-Tooth disease 1A (CMT1A) transgenic rat model Pmp22.
Definition
ChEBI: Naltrexone hydrochloride is a hydrochloride obtained by reaction of oxycodone with one molar equivalent of hydrochloric acid. it is a mu-opioid receptor antagonist that is used to treat alcohol dependence. It has a role as a mu-opioid receptor antagonist, an antidote to opioid poisoning and a central nervous system depressant. It contains a naltrexone(1+).
brand name
TREXAN
Biological Activity
Opioid antagonist.
Biochem/physiol Actions
Competitive antagonist for μ, κ, δ, and σ-opioid receptors; has greater oral efficacy and longer duration of action than naloxone.
Clinical Use
Opioid antagonist:
Adjunctive prophylactic treatment in patient’s
previously opioid dependant
Treatment of alcohol dependence
Drug interactions
Potentially hazardous interactions with other drugs
Opioids: Avoid concomitant use.
Metabolism
Naltrexone is well absorbed from the gastrointestinal tract but is subject to considerable first-pass metabolism and may undergo enterohepatic recycling. It is extensively metabolised in the liver and the major metabolite, 6-β-naltrexol, may also possess weak opioid antagonist activity. It is excreted mainly in the urine, <5% is excreted in the faeces. The renal clearance for naltrexone ranges from 30-127 mL/min and suggests that renal elimination is primarily by glomerular filtration
storage
Room temperature
Purification Methods
This narcotic antagonist has been purified by recrystallisation from MeOH and dried in air. The free base has m 168-170o after recrystallisation from Me2CO. [Cone et al. J Pharm Sci 64 618 1975, Gold et al. Med Res Rev 2 211 1982.]
Naltrexone hydrochloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan Nutra Biotechnology Co.,Ltd | +8617786394783 | nutrabiotech@outlook.com | China | 300 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2503 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 | sales@fine-chemtech.com | CHINA | 885 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | sales@sdzschem.com | China | 2931 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14336 | 58 |
| Beijing Yibai Biotechnology Co., Ltd | 0086-182-6772-3597 | sales04@yibaibiotech.com | CHINA | 419 | 58 |
View Lastest Price from Naltrexone hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-17 | Naltrexone hydrochloride
16676-29-2
|
US $1.10 / g | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd | |
 |
2023-07-22 | Naltrexone hydrochloride
16676-29-2
|
US $30.00 / kg | 1kg | 99% | 1000tons | Henan Bao Enluo International TradeCo.，LTD | |
 |
2021-11-02 | Naltrexone hydrochloride
16676-29-2
|
US $142.90 / g/Bag | 5g/Bag | 99% | 5kg | Baoji Guokang Healthchem co.,ltd |
-
- Naltrexone hydrochloride
16676-29-2
- US $1.10 / g
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
-
- Naltrexone hydrochloride
16676-29-2
- US $30.00 / kg
- 99%
- Henan Bao Enluo International TradeCo.，LTD
-
- Naltrexone hydrochloride
16676-29-2
- US $142.90 / g/Bag
- 99%
- Baoji Guokang Healthchem co.,ltd
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